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H3BJH0 (H3BJH0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Lrp5 Ensembl ENSMUSP00000134983 MGI 1278315
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000134983
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000134983

Ontologies

Keywords
   DomainRepeat SAAS SAAS000033
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from direct assay PubMed 11956231. Source: MGI

Wnt signaling pathway involved in dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

adipose tissue development

Inferred from Biological aspect of Ancestor. Source: RefGenome

anatomical structure regression

Inferred from mutant phenotype PubMed 16163358. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 15142971. Source: MGI

apoptotic process involved in patterning of blood vessels

Inferred from mutant phenotype PubMed 16163358. Source: MGI

bone marrow development

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

bone remodeling

Inferred from mutant phenotype PubMed 11956231PubMed 15207752PubMed 16790443PubMed 17147489PubMed 17627087. Source: MGI

branching involved in mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 16973609. Source: MGI

canonical Wnt signaling pathway

Inferred from direct assay PubMed 15143170. Source: MGI

cell migration involved in gastrulation

Inferred from genetic interaction PubMed 15142971. Source: MGI

cell-cell signaling involved in mammary gland development

Inferred from mutant phenotype PubMed 16973609. Source: MGI

cholesterol homeostasis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cholesterol metabolic process

Inferred from mutant phenotype PubMed 12509515. Source: MGI

embryonic camera-type eye morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 15142971. Source: MGI

embryonic retina morphogenesis in camera-type eye

Inferred from Biological aspect of Ancestor. Source: RefGenome

gastrulation with mouth forming second

Inferred from genetic interaction PubMed 15142971. Source: MGI

limb morphogenesis

Inferred from genetic interaction PubMed 15537447. Source: MGI

mammary gland duct morphogenesis

Inferred from genetic interaction PubMed 19503830. Source: MGI

osteoblast development

Inferred from mutant phenotype PubMed 16790443. Source: MGI

positive regulation of osteoblast proliferation

Inferred from mutant phenotype PubMed 11956231. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of apoptotic process

Inferred from mutant phenotype PubMed 11956231. Source: MGI

regulation of bone remodeling

Inferred from mutant phenotype PubMed 12817748. Source: MGI

regulation of fat cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of insulin secretion involved in cellular response to glucose stimulus

Inferred from mutant phenotype PubMed 12509515. Source: MGI

regulation of ossification

Inferred from Biological aspect of Ancestor. Source: RefGenome

retina vasculature morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 11956231PubMed 18263894. Source: MGI

retinal blood vessel morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19672307. Source: MGI

vasculature development

Inferred from mutant phenotype PubMed 16163358. Source: MGI

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 14651853. Source: MGI

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionWnt-activated receptor activity

Inferred from direct assay PubMed 11956231. Source: MGI

Wnt-protein binding

Inferred from physical interaction PubMed 11956231. Source: MGI

coreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H3BJH0 [UniParc].

Last modified April 18, 2012. Version 1.
Checksum: 6D1A15C7FAE1DE65

FASTA27930,888
        10         20         30         40         50         60 
METAPTRAPP PPPPPLLLLV LYCSLVPAAA SPLLLFANRR DVRLVDAGGV KLESTIVASG 

        70         80         90        100        110        120 
LEDAAAVDFQ FSKGAVYWTD VSEEAIKQTY LNQTGAAAQN IVISGLVSPD GLACDWVGKK 

       130        140        150        160        170        180 
LYWTDSETNR IEVANLNGTS RKVLFWQDLD QPRAIALDPA HGYMYWTDWG EAPRIERAGM 

       190        200        210        220        230        240 
DGSTRKIIVD SDIYWPNGLT IDLEEQKLYW ADAKLSFIHR ANLDGSFRNM LNVPSKLCER 

       250        260        270 
NIHSLRDGSC ARRALSSIPA GHTIRGRRWW RAASLTLLP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC112990 Genomic DNA. No translation available.
AC117797 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalH3BJH0.
SMRH3BJH0. Positions 31-228.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000177330; ENSMUSP00000134983; ENSMUSG00000024913.

Organism-specific databases

MGIMGI:1278315. Lrp5.

Phylogenomic databases

GeneTreeENSGT00750000117273.

Gene expression databases

ArrayExpressH3BJH0.
BgeeH3BJH0.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamPF00058. Ldl_recept_b. 2 hits.
[Graphical view]
SMARTSM00135. LY. 4 hits.
[Graphical view]
PROSITEPS51120. LDLRB. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35561520.
SOURCESearch...

Entry information

Entry nameH3BJH0_MOUSE
AccessionPrimary (citable) accession number: H3BJH0
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)