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Protein
Submitted name:

Rho guanine nucleotide exchange factor 2

Gene

Arhgef2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 2Imported
Submitted name:
Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_bImported
Gene namesi
Name:Arhgef2Imported
ORF Names:mCG_8844Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:103264. Arhgef2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029694.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7148Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini221 – 418198DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini458 – 557100PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili576 – 60328Sequence analysisAdd
BLAST
Coiled coili816 – 85035Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IR0Y. Eukaryota.
ENOG410XT68. LUCA.
GeneTreeiENSGT00760000119193.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H3BJ40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRDKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA
60 70 80 90 100
LICPTCNVTI HNRCKDTLAN CTKVKQKQQK AALLRNNTAL QSVSLRSKTT
110 120 130 140 150
TRERPTSAIY PSDSFRQSLL GSRRGLSSLS LAKSVSTTNI AGHFNDESPL
160 170 180 190 200
GLRQILSQST DSLNMRNRTL SVESLIDEGV EVFYNELMSD FEMDEKDFEA
210 220 230 240 250
DSWSLAVDSS FLQQHKKEVM KKQDVIYELI QTELHHVRTL KIMTRLFRTG
260 270 280 290 300
MLEELQMEPE VVQGLFPCVD ELSDIHTRFL NQLLERRRQA LCPGSTRNFV
310 320 330 340 350
IHRLGDLLIS QFSGSNAEQM RKTYSEFCSR HTKALKLYKE LYARDKRFQQ
360 370 380 390 400
FIRKMTRSAV LKRHGVQECI LLVTQRITKY PVLINRILQN SHGVEEEYQD
410 420 430 440 450
LASALGLVKE LLSNVDQDVH ELEKEARLQE IYNRMDPRAQ TPVPGKGPFG
460 470 480 490 500
RDELLRRKLI HEGCLLWKTA TGRFKDVLLL LMTDVLVFLQ EKDQKYIFTS
510 520 530 540 550
LDKPSVVSLQ NLIVRDIANQ AKGMFLISSG PPEMYEVHAA SRDDRTTWIR
560 570 580 590 600
VIQQSVRLCP SREDFPLIET EDKAYLRRIK TKLQQKNQAL VELLQKNVEL
610 620 630 640 650
FAEMVHFQAL KAGFVGMPPP ALPRGLFRLE SFESLRGERL LKDALREVEG
660 670 680 690 700
LKDLLLGPCV DLPMTSREPA LPLDSDSGSC PGVTANGEAR TFNGSIELCR
710 720 730 740 750
ADSDSSQKDR NGNQLRSPQE EVLQPLINLY GLLHGLQAVV VQQERLMEAL
760 770 780 790 800
FPEGPERWEK LSRANSRDGE AGRAAVASVT PEKQATELAL LQRQHTLLQE
810 820 830 840 850
ELRRCQRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEI RRQLAALGQN
860 870 880 890 900
EPLPAEAPWA RRPLDPRRRS LPAGDALYLS FNPPQPSRGH DRLDLPVTVR
910 920 930 940 950
SLHRPFDDRE AQELGSPEDR LQDSSDPDTG SEEEVSSRLS PPHSPRDFTR
960 970
MQDIPEETES RDGEPTASES
Length:970
Mass (Da):110,204
Last modified:April 18, 2012 - v1
Checksum:iA012BD65CDB77933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145168 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15257.1.
RefSeqiXP_006501129.1. XM_006501066.1.
UniGeneiMm.239329.
Mm.482396.

Genome annotation databases

EnsembliENSMUST00000175779; ENSMUSP00000135177; ENSMUSG00000028059.
ENSMUST00000176500; ENSMUSP00000134834; ENSMUSG00000028059.
GeneIDi16800.
UCSCiuc008pvu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145168 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15257.1.
RefSeqiXP_006501129.1. XM_006501066.1.
UniGeneiMm.239329.
Mm.482396.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029694.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000175779; ENSMUSP00000135177; ENSMUSG00000028059.
ENSMUST00000176500; ENSMUSP00000134834; ENSMUSG00000028059.
GeneIDi16800.
UCSCiuc008pvu.2. mouse.

Organism-specific databases

CTDi9181.
MGIiMGI:103264. Arhgef2.

Phylogenomic databases

eggNOGiENOG410IR0Y. Eukaryota.
ENOG410XT68. LUCA.
GeneTreeiENSGT00760000119193.

Miscellaneous databases

ChiTaRSiArhgef2. mouse.
NextBioi35561411.
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiH3BJ40_MOUSE
AccessioniPrimary (citable) accession number: H3BJ40
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.