UniProtKB - H3BJ40 (H3BJ40_MOUSE)
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Protein
Submitted name:
Rho guanine nucleotide exchange factor 2
Gene
Arhgef2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
- regulation of Rho protein signal transduction Source: InterPro
Keywordsi
Ligand | Metal-bindingSAAS annotation, ZincSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Rho guanine nucleotide exchange factor 2ImportedSubmitted name: Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_bImported |
Gene namesi | Name:Arhgef2Imported ORF Names:mCG_8844Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103264. Arhgef2. |
Subcellular locationi
Interactioni
GO - Molecular functioni
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 71 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 48 | |
Domaini | 221 – 418 | DHInterPro annotationAdd BLAST | 198 | |
Domaini | 458 – 557 | PHInterPro annotationAdd BLAST | 100 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 576 – 603 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 788 – 808 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 816 – 850 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | ENOG410IR0Y. Eukaryota. ENOG410XT68. LUCA. |
GeneTreei | ENSGT00760000119193. |
Family and domain databases
CDDi | cd00029. C1. 1 hit. cd13393. PH_ARHGEF2. 1 hit. cd00160. RhoGEF. 1 hit. |
Gene3Di | 1.20.900.10. 1 hit. 2.30.29.30. 1 hit. |
InterProi | View protein in InterPro IPR037806. ARHGEF2_PH. IPR035899. DBL_dom_sf. IPR000219. DH-domain. IPR002219. PE/DAG-bd. IPR011993. PH-like_dom_sf. IPR001849. PH_domain. |
Pfami | View protein in Pfam PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. |
SMARTi | View protein in SMART SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. |
SUPFAMi | SSF48065. SSF48065. 1 hit. |
PROSITEi | View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
H3BJ40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGRDKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA
60 70 80 90 100
LICPTCNVTI HNRCKDTLAN CTKVKQKQQK AALLRNNTAL QSVSLRSKTT
110 120 130 140 150
TRERPTSAIY PSDSFRQSLL GSRRGLSSLS LAKSVSTTNI AGHFNDESPL
160 170 180 190 200
GLRQILSQST DSLNMRNRTL SVESLIDEGV EVFYNELMSD FEMDEKDFEA
210 220 230 240 250
DSWSLAVDSS FLQQHKKEVM KKQDVIYELI QTELHHVRTL KIMTRLFRTG
260 270 280 290 300
MLEELQMEPE VVQGLFPCVD ELSDIHTRFL NQLLERRRQA LCPGSTRNFV
310 320 330 340 350
IHRLGDLLIS QFSGSNAEQM RKTYSEFCSR HTKALKLYKE LYARDKRFQQ
360 370 380 390 400
FIRKMTRSAV LKRHGVQECI LLVTQRITKY PVLINRILQN SHGVEEEYQD
410 420 430 440 450
LASALGLVKE LLSNVDQDVH ELEKEARLQE IYNRMDPRAQ TPVPGKGPFG
460 470 480 490 500
RDELLRRKLI HEGCLLWKTA TGRFKDVLLL LMTDVLVFLQ EKDQKYIFTS
510 520 530 540 550
LDKPSVVSLQ NLIVRDIANQ AKGMFLISSG PPEMYEVHAA SRDDRTTWIR
560 570 580 590 600
VIQQSVRLCP SREDFPLIET EDKAYLRRIK TKLQQKNQAL VELLQKNVEL
610 620 630 640 650
FAEMVHFQAL KAGFVGMPPP ALPRGLFRLE SFESLRGERL LKDALREVEG
660 670 680 690 700
LKDLLLGPCV DLPMTSREPA LPLDSDSGSC PGVTANGEAR TFNGSIELCR
710 720 730 740 750
ADSDSSQKDR NGNQLRSPQE EVLQPLINLY GLLHGLQAVV VQQERLMEAL
760 770 780 790 800
FPEGPERWEK LSRANSRDGE AGRAAVASVT PEKQATELAL LQRQHTLLQE
810 820 830 840 850
ELRRCQRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEI RRQLAALGQN
860 870 880 890 900
EPLPAEAPWA RRPLDPRRRS LPAGDALYLS FNPPQPSRGH DRLDLPVTVR
910 920 930 940 950
SLHRPFDDRE AQELGSPEDR LQDSSDPDTG SEEEVSSRLS PPHSPRDFTR
960 970
MQDIPEETES RDGEPTASES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145168 Genomic DNA. No translation available. CH466547 Genomic DNA. Translation: EDL15257.1. |
RefSeqi | XP_006501129.1. XM_006501066.1. |
UniGenei | Mm.239329. Mm.482396. |
Genome annotation databases
Ensembli | ENSMUST00000175779; ENSMUSP00000135177; ENSMUSG00000028059. ENSMUST00000176500; ENSMUSP00000134834; ENSMUSG00000028059. |
GeneIDi | 16800. |
UCSCi | uc008pvu.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | H3BJ40_MOUSE | |
Accessioni | H3BJ40Primary (citable) accession number: H3BJ40 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 18, 2012 |
Last sequence update: | April 18, 2012 | |
Last modified: | March 28, 2018 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |