Rho guanine nucleotide exchange factor 2

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• metal ion binding Source: UniProtKB-KW
• Rho guanyl-nucleotide exchange factor activity Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• intracellular signal transduction Source: InterPro
• regulation of Rho protein signal transduction Source: InterPro

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Ligandⁱ

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• intracellular Source: GOC

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	24 – 71	48	Phorbol-ester/DAG-typeInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50081			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	221 – 418	198	DH (DBL-homology)InterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50010			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	458 – 557	100	PHInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50003			Add BLAST

Coiled coil

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Denotes the positions of regions of coiled coil within the protein.</p><p><a href='../manual/coiled' target='_top'>More...</a></p>Coiled coili	576 – 603	28	Sequence analysis <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More…</a></p> Automatic assertion according to rulesi SAM:Coils			Add BLAST
<p>Denotes the positions of regions of coiled coil within the protein.</p><p><a href='../manual/coiled' target='_top'>More...</a></p>Coiled coili	816 – 850	35	Sequence analysis <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More…</a></p> Automatic assertion according to rulesi SAM:Coils			Add BLAST

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTGRDKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA 
        60         70         80         90        100
LICPTCNVTI HNRCKDTLAN CTKVKQKQQK AALLRNNTAL QSVSLRSKTT 
       110        120        130        140        150
TRERPTSAIY PSDSFRQSLL GSRRGLSSLS LAKSVSTTNI AGHFNDESPL 
       160        170        180        190        200
GLRQILSQST DSLNMRNRTL SVESLIDEGV EVFYNELMSD FEMDEKDFEA 
       210        220        230        240        250
DSWSLAVDSS FLQQHKKEVM KKQDVIYELI QTELHHVRTL KIMTRLFRTG 
       260        270        280        290        300
MLEELQMEPE VVQGLFPCVD ELSDIHTRFL NQLLERRRQA LCPGSTRNFV 
       310        320        330        340        350
IHRLGDLLIS QFSGSNAEQM RKTYSEFCSR HTKALKLYKE LYARDKRFQQ 
       360        370        380        390        400
FIRKMTRSAV LKRHGVQECI LLVTQRITKY PVLINRILQN SHGVEEEYQD 
       410        420        430        440        450
LASALGLVKE LLSNVDQDVH ELEKEARLQE IYNRMDPRAQ TPVPGKGPFG 
       460        470        480        490        500
RDELLRRKLI HEGCLLWKTA TGRFKDVLLL LMTDVLVFLQ EKDQKYIFTS 
       510        520        530        540        550
LDKPSVVSLQ NLIVRDIANQ AKGMFLISSG PPEMYEVHAA SRDDRTTWIR 
       560        570        580        590        600
VIQQSVRLCP SREDFPLIET EDKAYLRRIK TKLQQKNQAL VELLQKNVEL 
       610        620        630        640        650
FAEMVHFQAL KAGFVGMPPP ALPRGLFRLE SFESLRGERL LKDALREVEG 
       660        670        680        690        700
LKDLLLGPCV DLPMTSREPA LPLDSDSGSC PGVTANGEAR TFNGSIELCR 
       710        720        730        740        750
ADSDSSQKDR NGNQLRSPQE EVLQPLINLY GLLHGLQAVV VQQERLMEAL 
       760        770        780        790        800
FPEGPERWEK LSRANSRDGE AGRAAVASVT PEKQATELAL LQRQHTLLQE 
       810        820        830        840        850
ELRRCQRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEI RRQLAALGQN 
       860        870        880        890        900
EPLPAEAPWA RRPLDPRRRS LPAGDALYLS FNPPQPSRGH DRLDLPVTVR 
       910        920        930        940        950
SLHRPFDDRE AQELGSPEDR LQDSSDPDTG SEEEVSSRLS PPHSPRDFTR 
       960        970
MQDIPEETES RDGEPTASES                                  

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ