Arhgef2

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
regulation of Rho protein signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-bindingSAAS annotation, ZincSAAS annotation

Ligand

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Rho guanine nucleotide exchange factor 2Imported Submitted name: Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_bImported
Gene namesⁱ	Name:Arhgef2Imported ORF Names:mCG_8844Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:103264. Arhgef2.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028059.

Bgeeⁱ

ENSMUSG00000028059.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 71	Phorbol-ester/DAG-typeInterPro annotationAdd BLAST	48
Domainⁱ	221 – 418	DH (DBL-homology)InterPro annotationAdd BLAST	198
Domainⁱ	458 – 557	PHInterPro annotationAdd BLAST	100

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	576 – 603	Sequence analysisAdd BLAST		28
Coiled coilⁱ	816 – 850	Sequence analysisAdd BLAST		35

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IR0Y. Eukaryota. ENOG410XT68. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119193.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

H3BJ40-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTGRDKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA 
        60         70         80         90        100
LICPTCNVTI HNRCKDTLAN CTKVKQKQQK AALLRNNTAL QSVSLRSKTT 
       110        120        130        140        150
TRERPTSAIY PSDSFRQSLL GSRRGLSSLS LAKSVSTTNI AGHFNDESPL 
       160        170        180        190        200
GLRQILSQST DSLNMRNRTL SVESLIDEGV EVFYNELMSD FEMDEKDFEA 
       210        220        230        240        250
DSWSLAVDSS FLQQHKKEVM KKQDVIYELI QTELHHVRTL KIMTRLFRTG 
       260        270        280        290        300
MLEELQMEPE VVQGLFPCVD ELSDIHTRFL NQLLERRRQA LCPGSTRNFV 
       310        320        330        340        350
IHRLGDLLIS QFSGSNAEQM RKTYSEFCSR HTKALKLYKE LYARDKRFQQ 
       360        370        380        390        400
FIRKMTRSAV LKRHGVQECI LLVTQRITKY PVLINRILQN SHGVEEEYQD 
       410        420        430        440        450
LASALGLVKE LLSNVDQDVH ELEKEARLQE IYNRMDPRAQ TPVPGKGPFG 
       460        470        480        490        500
RDELLRRKLI HEGCLLWKTA TGRFKDVLLL LMTDVLVFLQ EKDQKYIFTS 
       510        520        530        540        550
LDKPSVVSLQ NLIVRDIANQ AKGMFLISSG PPEMYEVHAA SRDDRTTWIR 
       560        570        580        590        600
VIQQSVRLCP SREDFPLIET EDKAYLRRIK TKLQQKNQAL VELLQKNVEL 
       610        620        630        640        650
FAEMVHFQAL KAGFVGMPPP ALPRGLFRLE SFESLRGERL LKDALREVEG 
       660        670        680        690        700
LKDLLLGPCV DLPMTSREPA LPLDSDSGSC PGVTANGEAR TFNGSIELCR 
       710        720        730        740        750
ADSDSSQKDR NGNQLRSPQE EVLQPLINLY GLLHGLQAVV VQQERLMEAL 
       760        770        780        790        800
FPEGPERWEK LSRANSRDGE AGRAAVASVT PEKQATELAL LQRQHTLLQE 
       810        820        830        840        850
ELRRCQRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEI RRQLAALGQN 
       860        870        880        890        900
EPLPAEAPWA RRPLDPRRRS LPAGDALYLS FNPPQPSRGH DRLDLPVTVR 
       910        920        930        940        950
SLHRPFDDRE AQELGSPEDR LQDSSDPDTG SEEEVSSRLS PPHSPRDFTR 
       960        970
MQDIPEETES RDGEPTASES

Length:970

Mass (Da):110,204

Last modified:April 18, 2012 - v1

Checksum:ⁱA012BD65CDB77933

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC145168 Genomic DNA. No translation available. CH466547 Genomic DNA. Translation: EDL15257.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_006501129.1. XM_006501066.1.
UniGeneⁱ	Mm.239329. Mm.482396.

Genome annotation databases

Ensemblⁱ	ENSMUST00000175779; ENSMUSP00000135177; ENSMUSG00000028059. ENSMUST00000176500; ENSMUSP00000134834; ENSMUSG00000028059.
GeneIDⁱ	16800.
UCSC genome browser More...UCSCⁱ	uc008pvu.2. mouse.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
H3BJ40	Q60875-4 Q3TYZ4 UPI0003D75F9E H3BL15 H3BJM4 UPI0003D708CC UPI0005ABA275	Mus musculus (Mouse)	970	UniRef100_H3BJ40	Cluster: Rho guanine nucleotide exchange factor 2	8

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
H3BJ40	Q60875 Q60875-2 A0A0G2K0V4 A0A1B0GWY5 UPI0003D07433 A0A1B0GWX8 UPI0003D0F925 UPI0003D0EF12 UPI0003D6F585 UPI000A31A989 +37	Mus musculus (Mouse) Rattus norvegicus (Rat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari)	985	UniRef90_Q60875	Cluster: Rho guanine nucleotide exchange factor 2	48

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
H3BJ40	Q92974 UPI000661EE6B UPI0003513695 UPI000661C526 UPI00063EEF0E UPI0004406F10 UPI0006573620 UPI0004F21E61 UPI0000DC5924 UPI0007A6DA19 +594	Homo sapiens (Human) Cavia porcellus (Guinea pig) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Heterocephalus glaber (Naked mole rat) Papio anubis (Olive baboon) Macaca mulatta (Rhesus macaque) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Mesocricetus auratus (Golden hamster) Odobenus rosmarus divergens (Pacific walrus) And more	986	UniRef50_Q92974	Cluster: Rho guanine nucleotide exchange factor 2	605

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC145168 Genomic DNA. No translation available. CH466547 Genomic DNA. Translation: EDL15257.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_006501129.1. XM_006501066.1.
UniGeneⁱ	Mm.239329. Mm.482396.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000175779; ENSMUSP00000135177; ENSMUSG00000028059. ENSMUST00000176500; ENSMUSP00000134834; ENSMUSG00000028059.
GeneIDⁱ	16800.
UCSC genome browser More...UCSCⁱ	uc008pvu.2. mouse.

Organism-specific databases

CTDⁱ	9181.
MGIⁱ	MGI:103264. Arhgef2.

Phylogenomic databases

eggNOGⁱ	ENOG410IR0Y. Eukaryota. ENOG410XT68. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119193.

Miscellaneous databases

ChiTaRSⁱ	Arhgef2. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028059.

Bgeeⁱ

ENSMUSG00000028059.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H3BJ40_MOUSE
Accessionⁱ	H3BJ40Primary (citable) accession number: H3BJ40
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 18, 2012
	Last sequence update:	April 18, 2012
	Last modified:	August 30, 2017
	This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - H3BJ40 (H3BJ40_MOUSE)

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Rho guanine nucleotide exchange factor 2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - H3BJ40 (H3BJ40_MOUSE)

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Rho guanine nucleotide exchange factor 2

Arhgef2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ