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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Latimeria chalumnae (West Indian ocean coelacanth)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37PhosphateUniRule annotation1
Binding sitei68PhosphateUniRule annotation1
Binding sitei120Phosphate; via amide nitrogenUniRule annotation1
Binding sitei205Purine nucleosideUniRule annotation1
Binding sitei224PhosphateUniRule annotation1
Binding sitei247Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
OrganismiLatimeria chalumnae (West Indian ocean coelacanth)Imported
Taxonomic identifieri7897 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
Proteomesi

Structurei

3D structure databases

ProteinModelPortaliH3ACL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 283PNP_UDP_1InterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
GeneTreeiENSGT00550000074740
KOiK03783
OMAiDQVAFNY

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

H3ACL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPEVSQGYT YEEYKETADW LLSKTELRPS IAIICGSGIG GLASVLKDQV
60 70 80 90 100
VFKYSDIPNF PQSTVPGHMG RLVFGKLNGK PCVCMQGRFH LYEGYPLSKV
110 120 130 140 150
TFPIRVFRLI GVETIIITNA AGGLNEDFKV GDIMVIKDHI NLLGFAGNNP
160 170 180 190 200
LVGHNEDRFG SRFPCMSDAY NRDLCKLAHE VGRELGFSNI IREGVYCAVG
210 220 230 240 250
GPSFETIAEC RMLNRLGADA VGMSTVHEVI VARHCGMRIF ALSLITNKAV
260 270 280 290
MDYDSEERAN HEEVLLAGKQ SSKYLEKLVS SLVTRIEHNN NVC
Length:293
Mass (Da):32,416
Last modified:April 18, 2012 - v1
Checksum:iCACCCFD5F852B8A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01211831 Genomic DNA No translation available.
AFYH01211832 Genomic DNA No translation available.
AFYH01211833 Genomic DNA No translation available.
AFYH01211834 Genomic DNA No translation available.
AFYH01211835 Genomic DNA No translation available.
AFYH01211836 Genomic DNA No translation available.
AFYH01211837 Genomic DNA No translation available.
AFYH01211838 Genomic DNA No translation available.
AFYH01211839 Genomic DNA No translation available.
RefSeqiXP_006009920.1, XM_006009858.2

Genome annotation databases

EnsembliENSLACT00000007448; ENSLACP00000007387; ENSLACG00000006551
GeneIDi102355345
KEGGilcm:102355345

Entry informationi

Entry nameiH3ACL6_LATCH
AccessioniPrimary (citable) accession number: H3ACL6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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