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Protein

Thymidine kinase

Gene

tk1

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tk1Imported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000033144.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3125. Eukaryota.
COG1435. LUCA.
GeneTreeiENSGT00390000011309.
InParanoidiH2U878.
KOiK00857.
OMAiCAGLDQD.
OrthoDBiEOG091G0HZR.
TreeFamiTF314839.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

H2U878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGGFSKIL PNSPKNARGQ IQVIFGPMFS GKSTELMRRV RRFQLAQYKC
60 70 80 90 100
LVIKYAKDTR YSDSGMATHD KNTMEAVPAN RLGDVHSQAL QVCVIGVDEG
110 120 130 140 150
QFFPDIVEFC EEMANLGKTI IVAALDGTFQ RKPFGSILNL VPLAESVVKL
160 170 180 190 200
NAVCMQCFKE AAYTKRIGAE KEVEVIGGAD KYQAVCRKCY GDLMVDKENR
210 220 230
SPCSDETPPH DHLEKLKDSA VPRKLFSSVI L
Length:231
Mass (Da):25,642
Last modified:March 21, 2012 - v1
Checksum:i4D581E434CF4CB11
GO

Sequence databases

RefSeqiXP_003972121.1. XM_003972072.2.

Genome annotation databases

EnsembliENSTRUT00000033270; ENSTRUP00000033144; ENSTRUG00000013060.
GeneIDi101063302.
KEGGitru:101063302.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiH2U878_TAKRU
AccessioniPrimary (citable) accession number: H2U878
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 5, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported