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Protein

Voltage-dependent N-type calcium channel subunit alpha

Gene

cacna1b

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:cacna1bImported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 117HelicalSequence analysisAdd BLAST18
Transmembranei138 – 159HelicalSequence analysisAdd BLAST22
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23
Transmembranei302 – 323HelicalSequence analysisAdd BLAST22
Transmembranei335 – 357HelicalSequence analysisAdd BLAST23
Transmembranei491 – 510HelicalSequence analysisAdd BLAST20
Transmembranei616 – 638HelicalSequence analysisAdd BLAST23
Transmembranei694 – 716HelicalSequence analysisAdd BLAST23
Transmembranei1146 – 1164HelicalSequence analysisAdd BLAST19
Transmembranei1184 – 1204HelicalSequence analysisAdd BLAST21
Transmembranei1216 – 1235HelicalSequence analysisAdd BLAST20
Transmembranei1277 – 1299HelicalSequence analysisAdd BLAST23
Transmembranei1389 – 1414HelicalSequence analysisAdd BLAST26
Transmembranei1470 – 1488HelicalSequence analysisAdd BLAST19
Transmembranei1500 – 1522HelicalSequence analysisAdd BLAST23
Transmembranei1591 – 1609HelicalSequence analysisAdd BLAST19
Transmembranei1680 – 1703HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1840 – 1874Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili712 – 739Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00830000128247.

Family and domain databases

InterProiView protein in InterPro
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 2 hits.
PfamiView protein in Pfam
PF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiView protein in SMART
SM01062. Ca_chan_IQ. 1 hit.

Sequencei

Sequence statusi: Complete.

H2SUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFAEDLPT RYGGSAGGGG RGGPGTGRGG ARAGGAAPGG QRVYKQSMAQ
60 70 80 90 100
RARTMAIYNP NPVKQNCLTV NRSLFIFRED NLIRKYAKRI TEWPYLYTPF
110 120 130 140 150
EYMILATIIA NCIVLALEQH LPASDKTPMS ERLDDTEPYF IGIFCFEAAI
160 170 180 190 200
KIIALGFAFH KGSYLRNGWN VMDFVVVLSG ILATVGSDFD LRTLRAVRVL
210 220 230 240 250
RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAIVMF AIIGVEFYMG
260 270 280 290 300
KFHTTCFRTD TGEKAADWSC GQEPPARICP NGTECREYWT GPNFGITNFD
310 320 330 340 350
NILFAILTVF QCITMEGWVD ILYSTNNVAG NTWNWLYFIP LIIIGSFFML
360 370 380 390 400
NLVLGVLSGE FAKERERVEK RQEFLKLRRQ QQIERELTGY LEWICKAEEV
410 420 430 440 450
LLEEEDEIAD EKSPLDAVLK RNKAKKGKND LIGAEEGEDP FADISSVAPP
460 470 480 490 500
GSPFGRASVK SSGKMDSSSY FRRKEKRVRF FIRRMVKAQS FYWIVLCVVG
510 520 530 540 550
LNTLCVAIVH YDQPEWLTKA LYTAEFVFLG LFLTEMTLKM YGLGVRNYFH
560 570 580 590 600
SSFNCFDFGV IVGSICEVIW DMITPGASFG ISVLRALRLL RIFKVTKYWN
610 620 630 640 650
SLRNLVISLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFEDETPT
660 670 680 690 700
TNFDTFPAAI LTVFQILTGE DWNAVMYHGI ESQGGVRRGM FSSVYFIVLT
710 720 730 740 750
LFGNYTLLNV FLAIAVDNLA NAQELTKDEE EQEEAANKKL ALQKALEVKE
760 770 780 790 800
VSPMSAANIS IAAKEQQRTA KTMSVWEQRT NQLRRHNMRA SSEALFNELD
810 820 830 840 850
PEERRRMSTA LHLHPDMKTH LDRPLIVEDR GGDKPARTPE GGHLESDHEG
860 870 880 890 900
HSRKHHRHRD RNGENREGCD GRGGRHHTHH SRSRDHNGNG SQSKERRGER
910 920 930 940 950
SHSRNGGQGH RHHHHHHNGS PEEEANDVRG GEERVHRHHH SHRPPKEGNG
960 970 980 990 1000
TIANGSQGDR KGKCGGGDSN GERKGHCSHV RAQPAGDGDD FKKNKNDAFW
1010 1020 1030 1040 1050
RERLEAESDH VCDEINISLP REKTPDAQED GLASTPLQAM RGGLTAGEKQ
1060 1070 1080 1090 1100
EDADNLKNST RASQAGLNSN AIHIPVTITA PPGETTLIPM NNIDCESFQI
1110 1120 1130 1140 1150
REEKKNLEEA EEVNGPRQML PYSSMFIFGQ TNPVRRLCHY VVNLRYFEMC
1160 1170 1180 1190 1200
ILIVITMSSI ALAAEDPVQA NAPRNNVLKY LDYVFTGVFT FEMVIKMIDL
1210 1220 1230 1240 1250
GLLLHPGSYF RDLWNILDFI VVSGALVAFA CSGTKGKDIN TIKSLRVLRV
1260 1270 1280 1290 1300
LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYILFMFI FAVIAVQLFK
1310 1320 1330 1340 1350
GKFFYCTDES KVLEKDCRGH FLEYDKDHVT AQPREWKKYD FHYDNVLWAF
1360 1370 1380 1390 1400
LTLFTVSTGE GWPMVLKHSV DATYEDQGPN PGFRMETSIF YVVYFVVFPF
1410 1420 1430 1440 1450
FFVNIFVALI IITFQEQGDK AMSECSLEKN ERACIDFAIN AKPLTRYMPE
1460 1470 1480 1490 1500
NKLSFQYKMW KFVVSPPFEY AIMTLIALNT VVLMMKFYGA PDLYESMLKY
1510 1520 1530 1540 1550
LNIVFTALFT LECILKIIAF GPLNYLKAAW NVFDFVTVLG SITDILVTEV
1560 1570 1580 1590 1600
KDKMINLSFL RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA
1610 1620 1630 1640 1650
MLFFIYAIIG MQVFGNIELI EESAIHRHNN FQTFFQALTL LFRSATGEAW
1660 1670 1680 1690 1700
HEIMLACLSN RPCDKLSGTV GNECGSDFAY FYFVSFIFLC SFLMLNLFVA
1710 1720 1730 1740 1750
VIMDNFEYLT RDASILGPHH LDEFIRVWAE YDPAACGRIC YQDMYKLLLF
1760 1770 1780 1790 1800
ISPPLGLGKK CPNRVAYKRL VKMNMPIADD NTVHFTSTLM ALIRTALEIK
1810 1820 1830 1840 1850
LASGVLVQRL YDADLKREIS RVWPSLPQKT IDLLVTPHKY NELTVGKVYA
1860 1870 1880 1890 1900
ALMIFDYYKQ NRAKRLQQQQ QSSTGPQSLF AVLQQVSCQC SSLCSCVYRQ
1910 1920 1930 1940 1950
TRRSAIKHSQ SGDVSQATQR LKGRKKLQRG LSEDVPYCTR PQESVELKQV
1960 1970 1980 1990 2000
DNISDTDEYL SLDGHGRAAS LPRLNAEYYP IVDLSPIRRS ASSLTQHHQD
2010 2020 2030 2040 2050
VRLKDFDLER PDLAQSLIHH HHHRCHRRRD RDKEKKQKSI DRPVQPSSTV
2060 2070 2080 2090 2100
DSFTDPSAQG LSRERARERD RSRPHERRHH SSAGEKQRYY SCERYSSREQ
2110 2120 2130 2140 2150
CHTKSAGPSR STSPGEGQEV AFLKQYGSTV VKAGPVMLPS GSTTPGRGRR
2160 2170 2180 2190 2200
QLPQTPLTPR PAVTYKSAHP STLPSSLSTT MTGHQTRFSR GLSEHERLVG
2210 2220 2230 2240 2250
VQGETLMPIT CIGSDPNLNR HPEVAPQQDL LEETEDYHDT VSSHGVVCTA
2260 2270 2280 2290 2300
RTTPVSTTAS VSQGTAAAPI TSPPRQGRAG AMPNGYHFTL GVNSASGSGS
2310
RGTGSLRERE EEDWC
Length:2,315
Mass (Da):261,655
Last modified:March 21, 2012 - v1
Checksum:iEBB3811969161885
GO

Genome annotation databases

EnsembliENSTRUT00000016179; ENSTRUP00000016107; ENSTRUG00000006562.

Similar proteinsi

Entry informationi

Entry nameiH2SUM0_TAKRU
AccessioniPrimary (citable) accession number: H2SUM0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 25, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported