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Protein
Submitted name:

5-hydroxytryptamine receptor 4

Gene

HTR4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine receptor 4Imported
Gene namesi
Name:HTR4Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 45HelicalSequence analysisAdd BLAST26
Transmembranei57 – 79HelicalSequence analysisAdd BLAST23
Transmembranei99 – 117HelicalSequence analysisAdd BLAST19
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei192 – 213HelicalSequence analysisAdd BLAST22
Transmembranei260 – 281HelicalSequence analysisAdd BLAST22
Transmembranei293 – 315HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiH2R334.

Expressioni

Gene expression databases

BgeeiENSPTRG00000017389.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000044834.

Structurei

3D structure databases

ProteinModelPortaliH2R334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 312G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139340.
InParanoidiH2R334.
KOiK04160.
OMAiWIYGETF.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

CDDicd15056. 7tmA_5-HT4. 1 hit.
InterProiView protein in InterPro
IPR001520. 5HT4_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01059. 5HT4RECEPTR.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H2R334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL
60 70 80 90 100
RKIKTNYFIV SLAFADLLVS VLVMPFGAIE LVQDIWIYGE MFCLVRTSLD
110 120 130 140 150
VLLTTASIFH LCCISLDRYY AICCQPLVYR NKMTPLRIAL MLGGCWVIPT
160 170 180 190 200
FISFLPIMQG WNNIGIIDLI EKRKFNQNSN STYCVFMVNK PYAITCSVVA
210 220 230 240 250
FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP QSADQHSTHR
260 270 280 290 300
MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL
310 320 330 340 350
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT
360 370 380 390 400
INGSTHVLRT DFLFDRDILA RYWTKPARAG PFSGTLSIRC LTARKPVLGD
410 420
AVECGGQWES QCHPPATSPL VAAQPSDT
Length:428
Mass (Da):48,287
Last modified:March 21, 2012 - v1
Checksum:iC4C80A51848D3798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03039194 Genomic DNA. No translation available.
AACZ03039195 Genomic DNA. No translation available.
AACZ03039196 Genomic DNA. No translation available.
AACZ03039197 Genomic DNA. No translation available.
AACZ03039198 Genomic DNA. No translation available.
AACZ03039199 Genomic DNA. No translation available.
AACZ03039200 Genomic DNA. No translation available.
AACZ03039201 Genomic DNA. No translation available.
AACZ03039202 Genomic DNA. No translation available.
RefSeqiXP_001162258.1. XM_001162258.5.

Genome annotation databases

EnsembliENSPTRT00000046976; ENSPTRP00000044834; ENSPTRG00000017389.
GeneIDi462175.
KEGGiptr:462175.

Similar proteinsi

Entry informationi

Entry nameiH2R334_PANTR
AccessioniPrimary (citable) accession number: H2R334
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 25, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported