ID   H2R328_PANTR            Unreviewed;      2665 AA.
AC   H2R328;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Nuclear receptor binding SET domain protein 1 {ECO:0000313|Ensembl:ENSPTRP00000044805.5};
GN   Name=NSD1 {ECO:0000313|Ensembl:ENSPTRP00000044805.5,
GN   ECO:0000313|VGNC:VGNC:6953};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000044805.5, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000044805.5, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000044805.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACZ04060243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04060244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPTRT00000042784.5; ENSPTRP00000044805.5; ENSPTRG00000017575.6.
DR   VGNC; VGNC:6953; NSD1.
DR   eggNOG; KOG1081; Eukaryota.
DR   GeneTree; ENSGT00940000155027; -.
DR   HOGENOM; CLU_000756_0_0_1; -.
DR   TreeFam; TF329088; -.
DR   Proteomes; UP000002277; Chromosome 5.
DR   Bgee; ENSPTRG00000017575; Expressed in lymph node and 21 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15648; PHD1_NSD1_2; 1.
DR   CDD; cd15650; PHD2_NSD1; 1.
DR   CDD; cd15653; PHD3_NSD1; 1.
DR   CDD; cd15656; PHD4_NSD1; 1.
DR   CDD; cd15659; PHD5_NSD1; 1.
DR   CDD; cd20164; PWWP_NSD1_rpt2; 1.
DR   CDD; cd19210; SET_NSD1; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 4.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR041306; C5HCH.
DR   InterPro; IPR047426; PHD1_NSD1_2.
DR   InterPro; IPR047428; PHD2_NSD1.
DR   InterPro; IPR047429; PHD3_NSD1.
DR   InterPro; IPR047430; PHD4_NSD1.
DR   InterPro; IPR047432; PHD5_NSD1.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR047423; PWWP_NSD1_rpt2.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR047433; SET_NSD1.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22884:SF312; HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF17982; C5HCH; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00249; PHD; 5.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00293; PWWP; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          1512..1558
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1676..1720
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   DOMAIN          1725..1787
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   DOMAIN          1859..1909
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          1911..2028
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          2035..2051
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          207..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..859
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          904..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1037..1057
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1080..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1212..1241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1264..1313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1351..1397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1433..1504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2060..2080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2182..2391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2433..2468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2565..2585
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2634..2665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..859
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        904..956
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1264..1287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1369..1383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1435..1450
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1451..1469
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1479..1497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2186..2201
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2222..2237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2249..2263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2300..2318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2364..2378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2644..2659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2665 AA;  292965 MW;  1B8224112F651802 CRC64;
     MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STVSGTSQNA
     YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQTP IVCTSLSPGG
     PTALAMKQEP SCNNSPELQV KVTKTIKNGF LHFENFTCVD DADVDSEMDP EQPVTEDESI
     EEIFEETQTN ATCNYETKSE NGVKVAMGSE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ
     RNEVDGSNEK AALLPAPFSL GDTNITIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS
     SSTSQELPFV SSFWETCNKF VFVSNRRPYR QYYVEAFGDP SERAWVAGKA IVMFEGRHQF
     EELPVLRRRG KQKEKGYRHK VPQKILSKWE ASVGLAEQYD VPKGSKNRKC IPGSIKLDSE
     EDMPFEDCTN DPESEHDLLL NGCLKSLAFD SEHSADEKEK PCAKSRARKS SDNPKRTSVK
     KGHIQFEAHK DERRGKIPEN LGLNFISGDI SDTQASNELS RIANSLTGSN TAPGSFLFSS
     CGKNTAKKEF ETSNGDSLLG LPEGALISKC SREKNKPQRS LVCGSKVKLC YIGAGDEEKR
     SDSISICTTS DDGSSDLDPI EHSSESDNSV LEIPDAFDRT ENMLSMQKNE KIKYSRFAAT
     NTRVKAKQKP LISNSHTDHL MGCTKSAEPG TETSQVNLSD LKASTLVHKP QSDFTNDALS
     PKFNMSSSIS SENSLIKGGA ANQALLHSKS KQPKFRSIKC KHKENPVMVE PPVINEECSL
     KCCSSDTKGS PLASISKSGK VDGLKLLNNM HEKTRDSSDI ETAVVKHVLS ELKELSYRSL
     GEDVSDSGTS KPSKPLLFSS ASSQNHIPIE PDYKFSTLLM MLKDMHDSKT KEQRLMTAQN
     LVSYRSPGRG DCSTNSPVGV SKVLVSGGST HNSEKKGDGT QNSANPSPSG GDSALSGELS
     ASLPGLVSDK RDLPASGKSR SDCVTRRNCG RSKPSSKLRD AFSAQMVKNT VNRKALKTER
     KRKLNQLPSV TLDAVLQGDR EHGGSLRGGA EDPSKEDPLQ IMGHLTSEDG DHFSDVHFDS
     KVKQSDPGKI SEKGLSFENG KGPELDSVMN SENDELNGVN QVVPKKRWQR LNQRRTKPRK
     RMNRFKEKEN SECAFRVLLP SDPVQEGRDE FPEHRTPPSA SILEEPLTEQ NHADCLDSVG
     PRLNVCDKSS ASIGDMEKEP GIPSLTPQAE LPEPAVRSEK KRLRKPSKWL LEYTEEYDQI
     FAPKKKQKKV QEQVHKVSSR CEEESLLARG RSSAQNKQVD ENSLISTKEE PPVLEREAPF
     LEGPLAQSEL GGGHAELPQL TLSVPVAPEV SPRPALESEE LLVKTPGNYE SKRQRKPTKK
     LLESNDLDPG FMPKKGDLGL SKKCYEAGHL ENGITESCAT SYSKDFGGGT TKIFDKPRKR
     KRQRHAAAKM QCKKVKNDDS SKEIPGSEGE LMPHRTATSP KETVEEGVEH DPGMPASKKM
     QGERGGGAAL KENVCQNCEK LGELLLCEAQ CCGAFHLECL GLTEMPRGKF ICNECRTGIH
     TCFVCKQSGE DVKRCLLPLC GKFYHEECVQ KYPPTVMQNK GFRCSLHICI TCHAANPANV
     SASKGRLMRC VRCPVAYHAN DFCLAAGSKI LASNSIICPN HFTPRRGCRN HEHVNVSWCF
     VCSEGGSLLC CDSCPAAFHR ECLNIDIPEG NWYCNDCKAG KKPHYREIVW VKVGRYRWWP
     AEICHPRAVP SNIDKMRHDV GEFPVLFFGS NDYLWTHQAR VFPYMEGDVS SKDKMGKGVD
     GTYKKALQEA AARFEELKAQ KELRQLQEDR KNDKKPPPYK HIKVNRPIGR VQIFTADLSE
     IPRCNCKATD ENPCGIDSEC INRMLLYECH PTVCPAGGRC QNQCFSKRQY PEVEIFRTLQ
     RGWGLRTKTD IKKGEFVNEY VGELIDEEEC RARIRYAQEH DITNFYMLTL DKDRIIDAGP
     KGNYARFMNH CCQPNCETQK WSVNGDTRVG LFALSDIKAG TELTFNYNLE CLGNGKTVCK
     CGAPNCSGFL GVRPKNQPIA TEEKSKKFKK KQQGKRRTQG EITKEREDEC FSCGDAGQLV
     SCKKPGCPKV YHADCLNLTK RPAGKWECPW HQCDICGKEA ASFCEMCPSS FCKQHREGML
     FISKLDGRLS CTEHDPCGPN PLEPGEIREY VPPPVPLPPG PSTHLAEQST GMAAQAPKMS
     DKPPADTNQT LSLSKKALAG TCQRPLLPER PLERTDSRPQ PLDKVRDLAG SGTKSQSLVS
     SQRPLDRPPA VAGPRPQLSD KPSPVTSPSS SPSVRSQPLE RPLGTADPRL DKSIGAASPR
     PQSLEKTPVP TGLRLPPPDR LLITSSPKPQ TSDRPTDKPH ASLSQRLPPP EKVLSAVVQT
     LVAKEKALRP VDQNTQSKNR AALVMDLIDL TPRQKERAAS PHEVTPQADE KMPVLESSSW
     PASKGLGHMP RAVEKGCVSD PLQTSGKAAA PSEDPWQAVK SLTQARLLSQ PPAKAFLYEP
     TTQASGRASA GAEQTPGPLS QSLGLVKQAK QMVGGQQLPA LAAKSGQSFR SLGKAPASLP
     TEEKKLVTTE QSPWALGKAS SRAGLWPIVA GQTLAQSCWS AGSTQTLAQT CWSLGRGQDP
     KPEQNTLPAL NQAPSSHKCA ESEQK
//