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H2R328

- H2R328_PANTR

UniProt

H2R328 - H2R328_PANTR

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Protein
Submitted name:

Nuclear receptor binding SET domain protein 1

Gene

NSD1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. transcription cofactor activity Source: Ensembl
  4. zinc ion binding Source: Ensembl

GO - Biological processi

  1. gastrulation with mouth forming second Source: Ensembl
  2. positive regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, ReceptorImported, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor binding SET domain protein 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:NSD1Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118855.
InParanoidiH2R328.
KOiK15588.
OMAiECRTGIH.
OrthoDBiEOG7Z69BG.
TreeFamiTF329088.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2R328-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL
60 70 80 90 100
STVSGTSQNA YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP
110 120 130 140 150
EKSDSRAQTP IVCTSLSPGG PTALAMKQEP SCNNSPELQV KVTKTIKNGF
160 170 180 190 200
LHFENFTCVD DADVDSEMDP EQPVTEDESI EEIFEETQTN ATCNYETKSE
210 220 230 240 250
NGVKVAMGSE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ RNEVDGSNEK
260 270 280 290 300
AALLPAPFSL GDTNITIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS
310 320 330 340 350
SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH
360 370 380 390 400
SKMKVSNRRP YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR
410 420 430 440 450
RGKQKEKGYR HKVPQKILSK WEASVGLAEQ YDVPKGSKNR KCIPGSIKLD
460 470 480 490 500
SEEDMPFEDC TNDPESEHDL LLNGCLKSLA FDSEHSADEK EKPCAKSRAR
510 520 530 540 550
KSSDNPKRTS VKKGHIQFEA HKDERRGKIP ENLGLNFISG DISDTQASNE
560 570 580 590 600
LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNGDSL LGLPEGALIS
610 620 630 640 650
KCSREKNKPQ RSLVCGSKVK LCYIGAGDEE KRSDSISICT TSDDGSSDLD
660 670 680 690 700
PIEHSSESDN SVLEIPDAFD RTENMLSMQK NEKIKYSRFA ATNTRVKAKQ
710 720 730 740 750
KPLISNSHTD HLMGCTKSAE PGTETSQVNL SDLKASTLVH KPQSDFTNDA
760 770 780 790 800
LSPKFNMSSS ISSENSLIKG GAANQALLHS KSKQPKFRSI KCKHKENPVM
810 820 830 840 850
VEPPVINEEC SLKCCSSDTK GSPLASISKS GKVDGLKLLN NMHEKTRDSS
860 870 880 890 900
DIETAVVKHV LSELKELSYR SLGEDVSDSG TSKPSKPLLF SSASSQNHIP
910 920 930 940 950
IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG RGDCSTNSPV
960 970 980 990 1000
GVSKVLVSGG STHNSEKKGD GTQNSANPSP SGGDSALSGE LSASLPGLVS
1010 1020 1030 1040 1050
DKRDLPASGK SRSDCVTRRN CGRSKPSSKL RDAFSAQMVK NTVNRKALKT
1060 1070 1080 1090 1100
ERKRKLNQLP SVTLDAVLQG DREHGGSLRG GAEDPSKEDP LQIMGHLTSE
1110 1120 1130 1140 1150
DGDHFSDVHF DSKVKQSDPG KISEKGLSFE NGKGPELDSV MNSENDELNG
1160 1170 1180 1190 1200
VNQVVPKKRW QRLNQRRTKP RKRMNRFKEK ENSECAFRVL LPSDPVQEGR
1210 1220 1230 1240 1250
DEFPEHRTPP SASILEEPLT EQNHADCLDS VGPRLNVCDK SSASIGDMEK
1260 1270 1280 1290 1300
EPGIPSLTPQ AELPEPAVRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK
1310 1320 1330 1340 1350
KVQEQVHKVS SRCEEESLLA RGRSSAQNKQ VDENSLISTK EEPPVLEREA
1360 1370 1380 1390 1400
PFLEGPLAQS ELGGGHAELP QLTLSVPVAP EVSPRPALES EELLVKTPGN
1410 1420 1430 1440 1450
YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSKKCYEAG HLENGITESC
1460 1470 1480 1490 1500
ATSYSKDFGG GTTKIFDKPR KRKRQRHAAA KMQCKKVKND DSSKEIPGSE
1510 1520 1530 1540 1550
GELMPHRTAT SPKETVEEGV EHDPGMPASK KMQGERGGGA ALKENVCQNC
1560 1570 1580 1590 1600
EKLGELLLCE AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS
1610 1620 1630 1640 1650
GEDVKRCLLP LCGKFYHEEC VQKYPPTVMQ NKGFRCSLHI CITCHAANPA
1660 1670 1680 1690 1700
NVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC
1710 1720 1730 1740 1750
RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK
1760 1770 1780 1790 1800
AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF
1810 1820 1830 1840 1850
GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK
1860 1870 1880 1890 1900
AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA
1910 1920 1930 1940 1950
TDENPCGIDS ECINRMLLYE CHPTVCPAGG RCQNQCFSKR QYPEVEIFRT
1960 1970 1980 1990 2000
LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML
2010 2020 2030 2040 2050
TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK
2060 2070 2080 2090 2100
AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF
2110 2120 2130 2140 2150
KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL
2160 2170 2180 2190 2200
TKRPAGKWEC PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR
2210 2220 2230 2240 2250
LSCTEHDPCG PNPLEPGEIR EYVPPPVPLP PGPSTHLAEQ STGMAAQAPK
2260 2270 2280 2290 2300
MSDKPPADTN QTLSLSKKAL AGTCQRPLLP ERPLERTDSR PQPLDKVRDL
2310 2320 2330 2340 2350
AGSGTKSQSL VSSQRPLDRP PAVAGPRPQL SDKPSPVTSP SSSPSVRSQP
2360 2370 2380 2390 2400
LERPLGTADP RLDKSIGAAS PRPQSLEKTP VPTGLRLPPP DRLLITSSPK
2410 2420 2430 2440 2450
PQTSDRPTDK PHASLSQRLP PPEKVLSAVV QTLVAKEKAL RPVDQNTQSK
2460 2470 2480 2490 2500
NRAALVMDLI DLTPRQKERA ASPHEVTPQA DEKMPVLESS SWPASKGLGH
2510 2520 2530 2540 2550
MPRAVEKGCV SDPLQTSGKA AAPSEDPWQA VKSLTQARLL SQPPAKAFLY
2560 2570 2580 2590 2600
EPTTQASGRA SAGAEQTPGP LSQSLGLVKQ AKQMVGGQQL PALAAKSGQS
2610 2620 2630 2640 2650
FRSLGKAPAS LPTEEKKLVT TEQSPWALGK ASSRAGLWPI VAGQTLAQSC
2660 2670 2680 2690
WSAGSTQTLA QTCWSLGRGQ DPKPEQNTLP ALNQAPSSHK CAESEQK
Length:2,697
Mass (Da):296,787
Last modified:March 21, 2012 - v1
Checksum:i602F82967C45359E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03043090 Genomic DNA. No translation available.
AACZ03043091 Genomic DNA. No translation available.
AACZ03043092 Genomic DNA. No translation available.
AACZ03043093 Genomic DNA. No translation available.
AACZ03043094 Genomic DNA. No translation available.
AACZ03043095 Genomic DNA. No translation available.
AACZ03043096 Genomic DNA. No translation available.
AACZ03043097 Genomic DNA. No translation available.
AACZ03043098 Genomic DNA. No translation available.
AACZ03043099 Genomic DNA. No translation available.
AACZ03043100 Genomic DNA. No translation available.
AACZ03043101 Genomic DNA. No translation available.
AACZ03043102 Genomic DNA. No translation available.
AACZ03043103 Genomic DNA. No translation available.
AACZ03043104 Genomic DNA. No translation available.
AACZ03043105 Genomic DNA. No translation available.
AACZ03043106 Genomic DNA. No translation available.
AACZ03043107 Genomic DNA. No translation available.
AACZ03043108 Genomic DNA. No translation available.
GABD01002572 mRNA. Translation: JAA30528.1.
GABE01004826 mRNA. Translation: JAA39913.1.
RefSeqiXP_527132.2. XM_527132.3.

Genome annotation databases

EnsembliENSPTRT00000042784; ENSPTRP00000044805; ENSPTRG00000017575.
GeneIDi471754.
KEGGiptr:471754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03043090 Genomic DNA. No translation available.
AACZ03043091 Genomic DNA. No translation available.
AACZ03043092 Genomic DNA. No translation available.
AACZ03043093 Genomic DNA. No translation available.
AACZ03043094 Genomic DNA. No translation available.
AACZ03043095 Genomic DNA. No translation available.
AACZ03043096 Genomic DNA. No translation available.
AACZ03043097 Genomic DNA. No translation available.
AACZ03043098 Genomic DNA. No translation available.
AACZ03043099 Genomic DNA. No translation available.
AACZ03043100 Genomic DNA. No translation available.
AACZ03043101 Genomic DNA. No translation available.
AACZ03043102 Genomic DNA. No translation available.
AACZ03043103 Genomic DNA. No translation available.
AACZ03043104 Genomic DNA. No translation available.
AACZ03043105 Genomic DNA. No translation available.
AACZ03043106 Genomic DNA. No translation available.
AACZ03043107 Genomic DNA. No translation available.
AACZ03043108 Genomic DNA. No translation available.
GABD01002572 mRNA. Translation: JAA30528.1 .
GABE01004826 mRNA. Translation: JAA39913.1 .
RefSeqi XP_527132.2. XM_527132.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000042784 ; ENSPTRP00000044805 ; ENSPTRG00000017575 .
GeneIDi 471754.
KEGGi ptr:471754.

Organism-specific databases

CTDi 64324.

Phylogenomic databases

GeneTreei ENSGT00760000118855.
InParanoidi H2R328.
KOi K15588.
OMAi ECRTGIH.
OrthoDBi EOG7Z69BG.
TreeFami TF329088.

Family and domain databases

Gene3Di 3.30.40.10. 3 hits.
InterProi IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00249. PHD. 5 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 3 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skeletal muscleImported and SkinImported.

Entry informationi

Entry nameiH2R328_PANTR
AccessioniPrimary (citable) accession number: H2R328
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3