H2R328 (H2R328_PANTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Nuclear receptor binding SET domain protein 1 EMBL JAA30528.1

Submitted name:
Uncharacterized protein Ensembl ENSPTRP00000044805

Gene names

Name:	ENSG00000165671 Ensembl ENSPTRP00000044805
Synonyms:	NSD1 EMBL JAA30528.1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000044805

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	2697 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214 Contains 1 post-SET domain. SAAS SAAS001214

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase RuleBase RU004541 SAAS SAAS001214 Receptor EMBL JAA30528.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2R328 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 602F82967C45359E	FASTA	2,697	296,787
	10 20 30 40 50 60 MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STVSGTSQNA 70 80 90 100 110 120 YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQTP IVCTSLSPGG 130 140 150 160 170 180 PTALAMKQEP SCNNSPELQV KVTKTIKNGF LHFENFTCVD DADVDSEMDP EQPVTEDESI 190 200 210 220 230 240 EEIFEETQTN ATCNYETKSE NGVKVAMGSE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ 250 260 270 280 290 300 RNEVDGSNEK AALLPAPFSL GDTNITIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS 310 320 330 340 350 360 SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH SKMKVSNRRP 370 380 390 400 410 420 YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR RGKQKEKGYR HKVPQKILSK 430 440 450 460 470 480 WEASVGLAEQ YDVPKGSKNR KCIPGSIKLD SEEDMPFEDC TNDPESEHDL LLNGCLKSLA 490 500 510 520 530 540 FDSEHSADEK EKPCAKSRAR KSSDNPKRTS VKKGHIQFEA HKDERRGKIP ENLGLNFISG 550 560 570 580 590 600 DISDTQASNE LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNGDSL LGLPEGALIS 610 620 630 640 650 660 KCSREKNKPQ RSLVCGSKVK LCYIGAGDEE KRSDSISICT TSDDGSSDLD PIEHSSESDN 670 680 690 700 710 720 SVLEIPDAFD RTENMLSMQK NEKIKYSRFA ATNTRVKAKQ KPLISNSHTD HLMGCTKSAE 730 740 750 760 770 780 PGTETSQVNL SDLKASTLVH KPQSDFTNDA LSPKFNMSSS ISSENSLIKG GAANQALLHS 790 800 810 820 830 840 KSKQPKFRSI KCKHKENPVM VEPPVINEEC SLKCCSSDTK GSPLASISKS GKVDGLKLLN 850 860 870 880 890 900 NMHEKTRDSS DIETAVVKHV LSELKELSYR SLGEDVSDSG TSKPSKPLLF SSASSQNHIP 910 920 930 940 950 960 IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG RGDCSTNSPV GVSKVLVSGG 970 980 990 1000 1010 1020 STHNSEKKGD GTQNSANPSP SGGDSALSGE LSASLPGLVS DKRDLPASGK SRSDCVTRRN 1030 1040 1050 1060 1070 1080 CGRSKPSSKL RDAFSAQMVK NTVNRKALKT ERKRKLNQLP SVTLDAVLQG DREHGGSLRG 1090 1100 1110 1120 1130 1140 GAEDPSKEDP LQIMGHLTSE DGDHFSDVHF DSKVKQSDPG KISEKGLSFE NGKGPELDSV 1150 1160 1170 1180 1190 1200 MNSENDELNG VNQVVPKKRW QRLNQRRTKP RKRMNRFKEK ENSECAFRVL LPSDPVQEGR 1210 1220 1230 1240 1250 1260 DEFPEHRTPP SASILEEPLT EQNHADCLDS VGPRLNVCDK SSASIGDMEK EPGIPSLTPQ 1270 1280 1290 1300 1310 1320 AELPEPAVRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK KVQEQVHKVS SRCEEESLLA 1330 1340 1350 1360 1370 1380 RGRSSAQNKQ VDENSLISTK EEPPVLEREA PFLEGPLAQS ELGGGHAELP QLTLSVPVAP 1390 1400 1410 1420 1430 1440 EVSPRPALES EELLVKTPGN YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSKKCYEAG 1450 1460 1470 1480 1490 1500 HLENGITESC ATSYSKDFGG GTTKIFDKPR KRKRQRHAAA KMQCKKVKND DSSKEIPGSE 1510 1520 1530 1540 1550 1560 GELMPHRTAT SPKETVEEGV EHDPGMPASK KMQGERGGGA ALKENVCQNC EKLGELLLCE 1570 1580 1590 1600 1610 1620 AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS GEDVKRCLLP LCGKFYHEEC 1630 1640 1650 1660 1670 1680 VQKYPPTVMQ NKGFRCSLHI CITCHAANPA NVSASKGRLM RCVRCPVAYH ANDFCLAAGS 1690 1700 1710 1720 1730 1740 KILASNSIIC PNHFTPRRGC RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP 1750 1760 1770 1780 1790 1800 EGNWYCNDCK AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1810 1820 1830 1840 1850 1860 GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK AQKELRQLQE 1870 1880 1890 1900 1910 1920 DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA TDENPCGIDS ECINRMLLYE 1930 1940 1950 1960 1970 1980 CHPTVCPAGG RCQNQCFSKR QYPEVEIFRT LQRGWGLRTK TDIKKGEFVN EYVGELIDEE 1990 2000 2010 2020 2030 2040 ECRARIRYAQ EHDITNFYML TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR 2050 2060 2070 2080 2090 2100 VGLFALSDIK AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF 2110 2120 2130 2140 2150 2160 KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL TKRPAGKWEC 2170 2180 2190 2200 2210 2220 PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR LSCTEHDPCG PNPLEPGEIR 2230 2240 2250 2260 2270 2280 EYVPPPVPLP PGPSTHLAEQ STGMAAQAPK MSDKPPADTN QTLSLSKKAL AGTCQRPLLP 2290 2300 2310 2320 2330 2340 ERPLERTDSR PQPLDKVRDL AGSGTKSQSL VSSQRPLDRP PAVAGPRPQL SDKPSPVTSP 2350 2360 2370 2380 2390 2400 SSSPSVRSQP LERPLGTADP RLDKSIGAAS PRPQSLEKTP VPTGLRLPPP DRLLITSSPK 2410 2420 2430 2440 2450 2460 PQTSDRPTDK PHASLSQRLP PPEKVLSAVV QTLVAKEKAL RPVDQNTQSK NRAALVMDLI 2470 2480 2490 2500 2510 2520 DLTPRQKERA ASPHEVTPQA DEKMPVLESS SWPASKGLGH MPRAVEKGCV SDPLQTSGKA 2530 2540 2550 2560 2570 2580 AAPSEDPWQA VKSLTQARLL SQPPAKAFLY EPTTQASGRA SAGAEQTPGP LSQSLGLVKQ 2590 2600 2610 2620 2630 2640 AKQMVGGQQL PALAAKSGQS FRSLGKAPAS LPTEEKKLVT TEQSPWALGK ASSRAGLWPI 2650 2660 2670 2680 2690 VAGQTLAQSC WSAGSTQTLA QTCWSLGRGQ DPKPEQNTLP ALNQAPSSHK CAESEQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
[3]	"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences." Maudhoo M.D., Meehan D.T., Norgren R.B.Jr. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skeletal muscle EMBL JAA39913.1 and Skin EMBL JAA30528.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACZ03043090 Genomic DNA. No translation available. AACZ03043091 Genomic DNA. No translation available. AACZ03043092 Genomic DNA. No translation available. AACZ03043093 Genomic DNA. No translation available. AACZ03043094 Genomic DNA. No translation available. AACZ03043095 Genomic DNA. No translation available. AACZ03043096 Genomic DNA. No translation available. AACZ03043097 Genomic DNA. No translation available. AACZ03043098 Genomic DNA. No translation available. AACZ03043099 Genomic DNA. No translation available. AACZ03043100 Genomic DNA. No translation available. AACZ03043101 Genomic DNA. No translation available. AACZ03043102 Genomic DNA. No translation available. AACZ03043103 Genomic DNA. No translation available. AACZ03043104 Genomic DNA. No translation available. AACZ03043105 Genomic DNA. No translation available. AACZ03043106 Genomic DNA. No translation available. AACZ03043107 Genomic DNA. No translation available. AACZ03043108 Genomic DNA. No translation available. GABD01002572 mRNA. Translation: JAA30528.1. GABE01004826 mRNA. Translation: JAA39913.1.
RefSeq	XP_527132.2. XM_527132.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000042784; ENSPTRP00000044805; ENSPTRG00000017575.
GeneID	471754.
KEGG	ptr:471754.
Organism-specific databases
CTD	64324.
Phylogenomic databases
GeneTree	ENSGT00700000104009.
KO	K15588.
OMA	NIDKMRH.
Family and domain databases
Gene3D	3.30.40.10. 3 hits.
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR000313. PWWP. IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00628. PHD. 1 hit. PF00855. PWWP. 2 hits. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00249. PHD. 5 hits. SM00508. PostSET. 1 hit. SM00293. PWWP. 2 hits. SM00184. RING. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 3 hits.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50812. PWWP. 2 hits. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 2 hits. PS50016. ZF_PHD_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2R328_PANTR

Accession

Primary (citable) accession number: H2R328

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)