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H2R328

- H2R328_PANTR

UniProt

H2R328 - H2R328_PANTR

Protein
Submitted name:

Nuclear receptor binding SET domain protein 1

Gene

NSD1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. histone-lysine N-methyltransferase activity Source: InterPro
    3. transcription cofactor activity Source: Ensembl
    4. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. gastrulation with mouth forming second Source: Ensembl
    2. positive regulation of transcription, DNA-templated Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, ReceptorImported, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nuclear receptor binding SET domain protein 1Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:NSD1Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    KOiK15588.
    OMAiECRTGIH.
    OrthoDBiEOG7Z69BG.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2R328-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL     50
    STVSGTSQNA YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP 100
    EKSDSRAQTP IVCTSLSPGG PTALAMKQEP SCNNSPELQV KVTKTIKNGF 150
    LHFENFTCVD DADVDSEMDP EQPVTEDESI EEIFEETQTN ATCNYETKSE 200
    NGVKVAMGSE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ RNEVDGSNEK 250
    AALLPAPFSL GDTNITIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS 300
    SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH 350
    SKMKVSNRRP YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR 400
    RGKQKEKGYR HKVPQKILSK WEASVGLAEQ YDVPKGSKNR KCIPGSIKLD 450
    SEEDMPFEDC TNDPESEHDL LLNGCLKSLA FDSEHSADEK EKPCAKSRAR 500
    KSSDNPKRTS VKKGHIQFEA HKDERRGKIP ENLGLNFISG DISDTQASNE 550
    LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNGDSL LGLPEGALIS 600
    KCSREKNKPQ RSLVCGSKVK LCYIGAGDEE KRSDSISICT TSDDGSSDLD 650
    PIEHSSESDN SVLEIPDAFD RTENMLSMQK NEKIKYSRFA ATNTRVKAKQ 700
    KPLISNSHTD HLMGCTKSAE PGTETSQVNL SDLKASTLVH KPQSDFTNDA 750
    LSPKFNMSSS ISSENSLIKG GAANQALLHS KSKQPKFRSI KCKHKENPVM 800
    VEPPVINEEC SLKCCSSDTK GSPLASISKS GKVDGLKLLN NMHEKTRDSS 850
    DIETAVVKHV LSELKELSYR SLGEDVSDSG TSKPSKPLLF SSASSQNHIP 900
    IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG RGDCSTNSPV 950
    GVSKVLVSGG STHNSEKKGD GTQNSANPSP SGGDSALSGE LSASLPGLVS 1000
    DKRDLPASGK SRSDCVTRRN CGRSKPSSKL RDAFSAQMVK NTVNRKALKT 1050
    ERKRKLNQLP SVTLDAVLQG DREHGGSLRG GAEDPSKEDP LQIMGHLTSE 1100
    DGDHFSDVHF DSKVKQSDPG KISEKGLSFE NGKGPELDSV MNSENDELNG 1150
    VNQVVPKKRW QRLNQRRTKP RKRMNRFKEK ENSECAFRVL LPSDPVQEGR 1200
    DEFPEHRTPP SASILEEPLT EQNHADCLDS VGPRLNVCDK SSASIGDMEK 1250
    EPGIPSLTPQ AELPEPAVRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK 1300
    KVQEQVHKVS SRCEEESLLA RGRSSAQNKQ VDENSLISTK EEPPVLEREA 1350
    PFLEGPLAQS ELGGGHAELP QLTLSVPVAP EVSPRPALES EELLVKTPGN 1400
    YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSKKCYEAG HLENGITESC 1450
    ATSYSKDFGG GTTKIFDKPR KRKRQRHAAA KMQCKKVKND DSSKEIPGSE 1500
    GELMPHRTAT SPKETVEEGV EHDPGMPASK KMQGERGGGA ALKENVCQNC 1550
    EKLGELLLCE AQCCGAFHLE CLGLTEMPRG KFICNECRTG IHTCFVCKQS 1600
    GEDVKRCLLP LCGKFYHEEC VQKYPPTVMQ NKGFRCSLHI CITCHAANPA 1650
    NVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC 1700
    RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK 1750
    AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1800
    GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK 1850
    AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA 1900
    TDENPCGIDS ECINRMLLYE CHPTVCPAGG RCQNQCFSKR QYPEVEIFRT 1950
    LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML 2000
    TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK 2050
    AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IATEEKSKKF 2100
    KKKQQGKRRT QGEITKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL 2150
    TKRPAGKWEC PWHQCDICGK EAASFCEMCP SSFCKQHREG MLFISKLDGR 2200
    LSCTEHDPCG PNPLEPGEIR EYVPPPVPLP PGPSTHLAEQ STGMAAQAPK 2250
    MSDKPPADTN QTLSLSKKAL AGTCQRPLLP ERPLERTDSR PQPLDKVRDL 2300
    AGSGTKSQSL VSSQRPLDRP PAVAGPRPQL SDKPSPVTSP SSSPSVRSQP 2350
    LERPLGTADP RLDKSIGAAS PRPQSLEKTP VPTGLRLPPP DRLLITSSPK 2400
    PQTSDRPTDK PHASLSQRLP PPEKVLSAVV QTLVAKEKAL RPVDQNTQSK 2450
    NRAALVMDLI DLTPRQKERA ASPHEVTPQA DEKMPVLESS SWPASKGLGH 2500
    MPRAVEKGCV SDPLQTSGKA AAPSEDPWQA VKSLTQARLL SQPPAKAFLY 2550
    EPTTQASGRA SAGAEQTPGP LSQSLGLVKQ AKQMVGGQQL PALAAKSGQS 2600
    FRSLGKAPAS LPTEEKKLVT TEQSPWALGK ASSRAGLWPI VAGQTLAQSC 2650
    WSAGSTQTLA QTCWSLGRGQ DPKPEQNTLP ALNQAPSSHK CAESEQK 2697
    Length:2,697
    Mass (Da):296,787
    Last modified:March 21, 2012 - v1
    Checksum:i602F82967C45359E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03043090 Genomic DNA. No translation available.
    AACZ03043091 Genomic DNA. No translation available.
    AACZ03043092 Genomic DNA. No translation available.
    AACZ03043093 Genomic DNA. No translation available.
    AACZ03043094 Genomic DNA. No translation available.
    AACZ03043095 Genomic DNA. No translation available.
    AACZ03043096 Genomic DNA. No translation available.
    AACZ03043097 Genomic DNA. No translation available.
    AACZ03043098 Genomic DNA. No translation available.
    AACZ03043099 Genomic DNA. No translation available.
    AACZ03043100 Genomic DNA. No translation available.
    AACZ03043101 Genomic DNA. No translation available.
    AACZ03043102 Genomic DNA. No translation available.
    AACZ03043103 Genomic DNA. No translation available.
    AACZ03043104 Genomic DNA. No translation available.
    AACZ03043105 Genomic DNA. No translation available.
    AACZ03043106 Genomic DNA. No translation available.
    AACZ03043107 Genomic DNA. No translation available.
    AACZ03043108 Genomic DNA. No translation available.
    GABD01002572 mRNA. Translation: JAA30528.1.
    GABE01004826 mRNA. Translation: JAA39913.1.
    RefSeqiXP_527132.2. XM_527132.3.

    Genome annotation databases

    EnsembliENSPTRT00000042784; ENSPTRP00000044805; ENSPTRG00000017575.
    GeneIDi471754.
    KEGGiptr:471754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03043090 Genomic DNA. No translation available.
    AACZ03043091 Genomic DNA. No translation available.
    AACZ03043092 Genomic DNA. No translation available.
    AACZ03043093 Genomic DNA. No translation available.
    AACZ03043094 Genomic DNA. No translation available.
    AACZ03043095 Genomic DNA. No translation available.
    AACZ03043096 Genomic DNA. No translation available.
    AACZ03043097 Genomic DNA. No translation available.
    AACZ03043098 Genomic DNA. No translation available.
    AACZ03043099 Genomic DNA. No translation available.
    AACZ03043100 Genomic DNA. No translation available.
    AACZ03043101 Genomic DNA. No translation available.
    AACZ03043102 Genomic DNA. No translation available.
    AACZ03043103 Genomic DNA. No translation available.
    AACZ03043104 Genomic DNA. No translation available.
    AACZ03043105 Genomic DNA. No translation available.
    AACZ03043106 Genomic DNA. No translation available.
    AACZ03043107 Genomic DNA. No translation available.
    AACZ03043108 Genomic DNA. No translation available.
    GABD01002572 mRNA. Translation: JAA30528.1 .
    GABE01004826 mRNA. Translation: JAA39913.1 .
    RefSeqi XP_527132.2. XM_527132.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000042784 ; ENSPTRP00000044805 ; ENSPTRG00000017575 .
    GeneIDi 471754.
    KEGGi ptr:471754.

    Organism-specific databases

    CTDi 64324.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    KOi K15588.
    OMAi ECRTGIH.
    OrthoDBi EOG7Z69BG.
    TreeFami TF329088.

    Family and domain databases

    Gene3Di 3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Skeletal muscleImported and SkinImported.

    Entry informationi

    Entry nameiH2R328_PANTR
    AccessioniPrimary (citable) accession number: H2R328
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3