ID   H2R1P1_PANTR            Unreviewed;       719 AA.
AC   H2R1P1; A0A2J8L8T5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=Histone-lysine N-methyltransferase SETDB2 {ECO:0000256|ARBA:ARBA00040299};
DE            EC=2.1.1.366 {ECO:0000256|ARBA:ARBA00039052};
DE   AltName: Full=SET domain bifurcated 2 {ECO:0000256|ARBA:ARBA00042995};
GN   Name=SETDB2 {ECO:0000313|EMBL:JAA05943.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000042655.3, ECO:0000313|VGNC:VGNC:7303};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042655.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000042655.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA05943.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05943.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA38457.1}, Skin {ECO:0000313|EMBL:JAA23377.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA21689.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000042655.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CC         methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3]
CC         + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60288, Rhea:RHEA-
CC         COMP:15538, Rhea:RHEA-COMP:15541, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961,
CC         ChEBI:CHEBI:61976; EC=2.1.1.366;
CC         Evidence={ECO:0000256|ARBA:ARBA00036635};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AACZ04072370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01005395; JAA05943.1; -; mRNA.
DR   EMBL; GABF01000456; JAA21689.1; -; mRNA.
DR   EMBL; GABD01009723; JAA23377.1; -; mRNA.
DR   EMBL; GABE01006282; JAA38457.1; -; mRNA.
DR   RefSeq; XP_001153947.1; XM_001153947.5.
DR   RefSeq; XP_009425217.1; XM_009426942.2.
DR   STRING; 9598.ENSPTRP00000042655; -.
DR   PaxDb; 9598-ENSPTRP00000042655; -.
DR   Ensembl; ENSPTRT00000048180.4; ENSPTRP00000042655.3; ENSPTRG00000005873.6.
DR   GeneID; 452719; -.
DR   KEGG; ptr:452719; -.
DR   CTD; 83852; -.
DR   VGNC; VGNC:7303; SETDB2.
DR   eggNOG; KOG1141; Eukaryota.
DR   GeneTree; ENSGT00940000158209; -.
DR   HOGENOM; CLU_003279_2_0_1; -.
DR   OrthoDB; 2877903at2759; -.
DR   TreeFam; TF106411; -.
DR   Proteomes; UP000002277; Chromosome 13.
DR   Bgee; ENSPTRG00000005873; Expressed in lymph node and 21 other cell types or tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046974; F:histone H3K9 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   CDD; cd01395; HMT_MBD; 1.
DR   CDD; cd10523; SET_SETDB2; 1.
DR   Gene3D; 2.170.270.10; SET domain; 2.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR047232; SETDB1/2-like_MBD.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00391; MBD; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50982; MBD; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN          157..229
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   DOMAIN          291..364
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          367..694
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          72..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..547
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  81940 MW;  05DD253EA77F6EC5 CRC64;
     MGEKNGDAKT FWMELEDDGK VDFIFEQVQN VLQSLKQKIK DGSATNKEYI QAMILVNEAT
     IINSSTSIKG ASQKEVNAQS SDHMPVTQKE QENKSNAFPS TSCENSFPED CTFLTTENKE
     ILSLEDKVVD FREKDSSSNL SYQSHDCSGA CLMKMPLNLK GENPLQLPIK CHFQRRHAKT
     NSHSSALHVS YKTPCGRSLR NVEEVFRYLL ETECNFLFTD NFSFNTYVQL ARNYPKQKEV
     VSDVDISNGV ESVPISFCNE IDSRKLPQFK YRKTVWPRAY NLTNFSSMFT DSCDCSEGCI
     DITKCACLQL TARNAKTSPL SSDKITTGYK YKRLQRQIPT GIYECSLLCK CNRQLCQNRV
     VQHGPQVRLQ VFKTEQKGWG VRCLDDIDRG TFVCIYSGRL LSRANTEKSY GIDENGRDEN
     TMKNIFSKKR KLEVACSDCE VEVLPLGLET HPRTAKTEKC PPKFSNNPKE LTMETKYDNI
     SRIQYHSVIR DPESKTAIFQ HNGKKMEFVS SESVTPEDND GFKPPREHLN SKTKGAQKDS
     SSNHVDEFED NLLIESDVID ITKYREETPP RSRCNQATTL DNQNIKKAIE VQIQKPQEGR
     STACQRQQVF CDEELLSETK NTSSDSLTKF NKGNVFLLDA TKEGNVGRFL NHSCCPNLSV
     QNVFVETHNR NFPLVAFFTN RYVKARTELT WDYGYEAGTV PEKEIFCQCG VNKCRKKIL
//