H2R1P1 (H2R1P1_PANTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
SET domain, bifurcated 2 EMBL JAA05943.1

Submitted name:
Uncharacterized protein Ensembl ENSPTRP00000042655

Gene names

Name:	ENSG00000136169 Ensembl ENSPTRP00000042655
Synonyms:	SETDB2 EMBL JAA05943.1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000042655

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS007728 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS007728 Contains 1 pre-SET domain.

Ontologies

Keywords
Cellular component	Chromosome SAAS SAAS007728 Nucleus RuleBase RU004542 SAAS SAAS007728
Molecular function	Methyltransferase RuleBase RU004542 SAAS SAAS007728 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2R1P1 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 05DD253EA77F6EC5	FASTA	719	81,940
	10 20 30 40 50 60 MGEKNGDAKT FWMELEDDGK VDFIFEQVQN VLQSLKQKIK DGSATNKEYI QAMILVNEAT 70 80 90 100 110 120 IINSSTSIKG ASQKEVNAQS SDHMPVTQKE QENKSNAFPS TSCENSFPED CTFLTTENKE 130 140 150 160 170 180 ILSLEDKVVD FREKDSSSNL SYQSHDCSGA CLMKMPLNLK GENPLQLPIK CHFQRRHAKT 190 200 210 220 230 240 NSHSSALHVS YKTPCGRSLR NVEEVFRYLL ETECNFLFTD NFSFNTYVQL ARNYPKQKEV 250 260 270 280 290 300 VSDVDISNGV ESVPISFCNE IDSRKLPQFK YRKTVWPRAY NLTNFSSMFT DSCDCSEGCI 310 320 330 340 350 360 DITKCACLQL TARNAKTSPL SSDKITTGYK YKRLQRQIPT GIYECSLLCK CNRQLCQNRV 370 380 390 400 410 420 VQHGPQVRLQ VFKTEQKGWG VRCLDDIDRG TFVCIYSGRL LSRANTEKSY GIDENGRDEN 430 440 450 460 470 480 TMKNIFSKKR KLEVACSDCE VEVLPLGLET HPRTAKTEKC PPKFSNNPKE LTMETKYDNI 490 500 510 520 530 540 SRIQYHSVIR DPESKTAIFQ HNGKKMEFVS SESVTPEDND GFKPPREHLN SKTKGAQKDS 550 560 570 580 590 600 SSNHVDEFED NLLIESDVID ITKYREETPP RSRCNQATTL DNQNIKKAIE VQIQKPQEGR 610 620 630 640 650 660 STACQRQQVF CDEELLSETK NTSSDSLTKF NKGNVFLLDA TKEGNVGRFL NHSCCPNLSV 670 680 690 700 710 QNVFVETHNR NFPLVAFFTN RYVKARTELT WDYGYEAGTV PEKEIFCQCG VNKCRKKIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
[3]	"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences." Maudhoo M.D., Meehan D.T., Norgren R.B.Jr. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose stromal EMBL JAA05943.1, Skeletal muscle EMBL JAA38457.1, Skin EMBL JAA23377.1 and Smooth vascular EMBL JAA21689.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACZ03092694 Genomic DNA. No translation available. AACZ03092695 Genomic DNA. No translation available. GABC01005395 mRNA. Translation: JAA05943.1. GABF01000456 mRNA. Translation: JAA21689.1. GABD01009723 mRNA. Translation: JAA23377.1. GABE01006282 mRNA. Translation: JAA38457.1.
RefSeq	XP_001153947.1. XM_001153947.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000048180; ENSPTRP00000042655; ENSPTRG00000005873.
GeneID	452719.
KEGG	ptr:452719.
Organism-specific databases
CTD	83852.
Phylogenomic databases
GeneTree	ENSGT00690000101898.
KO	K11421.
OMA	KCHFQRR.
Family and domain databases
Gene3D	3.30.890.10. 1 hit.
InterPro	IPR016177. DNA-bd_integrase-typ. IPR001739. Methyl_CpG_DNA-bd. IPR007728. Pre-SET_dom. IPR001214. SET_dom. [Graphical view]
Pfam	PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF54171. DNA-binding_integrase-type. 1 hit.
PROSITE	PS50982. MBD. 1 hit. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2R1P1_PANTR

Accession

Primary (citable) accession number: H2R1P1

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	March 6, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)