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H2R0N1 (H2R0N1_PANTR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length3969 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSPTRP00000040970

Ontologies

Keywords
   DomainZinc-finger SAAS SAAS019787
   LigandMetal-binding
S-adenosyl-L-methionine SAAS SAAS001214
Zinc
   Molecular functionMethyltransferase RuleBase RU004541 SAAS SAAS001214
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA methylation

Inferred from electronic annotation. Source: Ensembl

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

embryonic hemopoiesis

Inferred from electronic annotation. Source: Ensembl

histone H3-K4 trimethylation

Inferred from electronic annotation. Source: Ensembl

histone H4-K16 acetylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular response to drug

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transporter activity

Inferred from electronic annotation. Source: Ensembl

protein complex assembly

Inferred from electronic annotation. Source: Ensembl

regulation of histone H3-K4 methylation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentMLL1 complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchromatin binding

Inferred from electronic annotation. Source: Ensembl

histone methyltransferase activity (H3-K4 specific)

Inferred from electronic annotation. Source: Ensembl

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

unmethylated CpG binding

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H2R0N1 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 7E01457087A93978

FASTA3,969431,726
        10         20         30         40         50         60 
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV 

        70         80         90        100        110        120 
AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA 

       130        140        150        160        170        180 
AIGTNLRRFR AVFGESGGGG GSGEDEQFLG FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR 

       190        200        210        220        230        240 
SGSDRNSAIL SDPSVFSPLN KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD 

       250        260        270        280        290        300 
ISELPKGNKE DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV 

       310        320        330        340        350        360 
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ SPRRIKPVRI 

       370        380        390        400        410        420 
IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK TQVKNIRQFI MPVVSAISSR 

       430        440        450        460        470        480 
IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSAPSCGSSE KSSAASQHSS QMSSDSSRSS 

       490        500        510        520        530        540 
SPSVDTSTDS QASEEIQVLP EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS 

       550        560        570        580        590        600 
RTTKKLSTLQ SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS 

       610        620        630        640        650        660 
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN FRPPPLTPED 

       670        680        690        700        710        720 
VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP RFTPSEAHSR IFESVTLPSN 

       730        740        750        760        770        780 
RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS PSHSMRTRSG RLSTSELSPL TPPSSVSSSL 

       790        800        810        820        830        840 
SISVSPLATS ALNPTFTFPS HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT 

       850        860        870        880        890        900 
PGSQTERGRN KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ 

       910        920        930        940        950        960 
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL GDTTAVKTKI 

       970        980        990       1000       1010       1020 
LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK HSTSSIGSML AQADKLPMTD 

      1030       1040       1050       1060       1070       1080 
KRVASLLKKA KAQLCKIEKS KSLKQTDQPK AQGQESDSSE TSVRGPRIKH VCRRAAVALG 

      1090       1100       1110       1120       1130       1140 
RKRAVFPDDM PTLSALPWEE REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA 

      1150       1160       1170       1180       1190       1200 
PQEPPVKKGR RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM 

      1210       1220       1230       1240       1250       1260 
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKD SSVVKNVVDS SQKPTPSARE DPAPKKSSSE 

      1270       1280       1290       1300       1310       1320 
PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ PALVIPPQPP TTGPPRKEVP 

      1330       1340       1350       1360       1370       1380 
KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK QENAGTLNIL 

      1390       1400       1410       1420       1430       1440 
STLSNGNSSK QKIPADGVHR IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS 

      1450       1460       1470       1480       1490       1500 
GHVEFVYCQV CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK 

      1510       1520       1530       1540       1550       1560 
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS HDFSLCHDCA 

      1570       1580       1590       1600       1610       1620 
KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE NLSDEMYEIL SNLPESVAYT 

      1630       1640       1650       1660       1670       1680 
CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP DLNPETEESI 

      1690       1700       1710       1720       1730       1740 
PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY TSVLEFSDDI VKIIQAAINS 

      1750       1760       1770       1780       1790       1800 
DGGQPEIKKA NSMVKSFFIR QMERVFPWFS VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH 

      1810       1820       1830       1840       1850       1860 
NYAQWQEREE NSHTEQPPLM KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE 

      1870       1880       1890       1900       1910       1920 
LNPPPGIEDN RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN 

      1930       1940       1950       1960       1970       1980 
VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK KVYCQRHRDL 

      1990       2000       2010       2020       2030       2040 
IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH MMIGSMTIDC LGILNDLSDC 

      2050       2060       2070       2080       2090       2100 
EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK IVECRPPVVE PDINSTVEHD ENRTIAHSPT 

      2110       2120       2130       2140       2150       2160 
SFTESSSKES QNTAEIISPP SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR 

      2170       2180       2190       2200       2210       2220 
PLPSAGSPTP TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS 

      2230       2240       2250       2260       2270       2280 
RNNVSSVSTI GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV VTVGNKNSHL 

      2290       2300       2310       2320       2330       2340 
DGSSSSEMKQ SSASDLASKS SSLKGEKTKV LSSKSSEGSA HNVAYPGIPK LAPQVHNTTS 

      2350       2360       2370       2380       2390       2400 
RELNVSKIGS FAEPSSVSFS SKEALSFPHL HLRGQRNDRD QHTDSTQSAN SSADEDTEVK 

      2410       2420       2430       2440       2450       2460 
TLKLSGMSNR SSIINEHMGS SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL 

      2470       2480       2490       2500       2510       2520 
KPEFMDEVLT PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV 

      2530       2540       2550       2560       2570       2580 
KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV AQPSPNNTSC 

      2590       2600       2610       2620       2630       2640 
QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS ARARSNMFFG LTPLYGVRSY 

      2650       2660       2670       2680       2690       2700 
GEEDIPFYSS STGKKRGKRS AEGQVDGADD LSTSDEDDLY YYNFTRTVIS SGGEERLASH 

      2710       2720       2730       2740       2750       2760 
NLFREEEQCD LPKISQLDGV DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED 

      2770       2780       2790       2800       2810       2820 
AGEKDHVTKS SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL 

      2830       2840       2850       2860       2870       2880 
LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS SSELLNLGEG 

      2890       2900       2910       2920       2930       2940 
LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ FELPLELPSD LSVLTTRSPT 

      2950       2960       2970       2980       2990       3000 
VPSQNPSRLA VISDSGEKRV TITEKSVASS EGDPALLSPG VDPTPEGHMT PDHFIQGHMD 

      3010       3020       3030       3040       3050       3060 
ADHISSPPCG SVEQGHGNNQ DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS 

      3070       3080       3090       3100       3110       3120 
NAAVQTTPPH LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS 

      3130       3140       3150       3160       3170       3180 
VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ SSFPPNISNP 

      3190       3200       3210       3220       3230       3240 
PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK RPISRLQTRK NKKLAPSSTP 

      3250       3260       3270       3280       3290       3300 
SNIAPSDVVS NMTLINFTPS QLPNHPSLLD LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP 

      3310       3320       3330       3340       3350       3360 
LLPQSVGGTA ATAAGTSTIS QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG 

      3370       3380       3390       3400       3410       3420 
HVTLTNPRLL GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAM 

      3430       3440       3450       3460       3470       3480 
TAASSICVLP STQTTGITAA SPSGEADEHY QLQHVNQLLA SKTGIHSSQR DLDSASGPQV 

      3490       3500       3510       3520       3530       3540 
SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS SGQRSASPSV PGPTKPKPKT 

      3550       3560       3570       3580       3590       3600 
KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP DQETTSLTSG TGTPGAEAEQ QDTASVEQSS 

      3610       3620       3630       3640       3650       3660 
QKECGQPAGQ VAVLPEVQVT QNPANEQEST EPKTVEEEES NFSSPLMLWL QQEQKRKESI 

      3670       3680       3690       3700       3710       3720 
TEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML 

      3730       3740       3750       3760       3770       3780 
GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL RKSAFDMFNF 

      3790       3800       3810       3820       3830       3840 
LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG 

      3850       3860       3870       3880       3890       3900 
RGLFCKRNID AGEMVIEYAG NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN 

      3910       3920       3930       3940       3950       3960 
AARFINHSCE PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG 


AKKCRKFLN 

« Hide

References

« Hide 'large scale' references
[1]"Initial sequence of the chimpanzee genome and comparison with the human genome."
Chimpanzee sequencing and analysis consortium
Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACZ03080830 Genomic DNA. No translation available.
AACZ03080831 Genomic DNA. No translation available.
AACZ03080832 Genomic DNA. No translation available.
AACZ03080833 Genomic DNA. No translation available.
AACZ03080834 Genomic DNA. No translation available.
AACZ03080835 Genomic DNA. No translation available.
AACZ03080836 Genomic DNA. No translation available.
RefSeqXP_508792.2. XM_508792.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000044431; ENSPTRP00000040970; ENSPTRG00000004344.
GeneID451587.
KEGGptr:451587.

Organism-specific databases

CTD414897.

Phylogenomic databases

GeneTreeENSGT00740000115089.
KOK09186.
OMARIMSPMR.
OrthoDBEOG7XH6NX.
TreeFamTF319820.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.30.40.10. 2 hits.
InterProIPR017956. AT_hook_DNA-bd_motif.
IPR001487. Bromodomain.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFPIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTSM00384. AT_hook. 3 hits.
SM00297. BROMO. 1 hit.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEPS50014. BROMODOMAIN_2. 1 hit.
PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2R0N1_PANTR
AccessionPrimary (citable) accession number: H2R0N1
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)