H2R0N1 (H2R0N1_PANTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSPTRP00000040970

Gene names

Name:

ENSG00000118058 Ensembl ENSPTRP00000040970

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000040970

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	3969 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSPTRP00000040970

Ontologies

Keywords
Domain	Zinc-finger SAAS SAAS001965
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	histone methyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone methyltransferase activity (H3-K4 specific) Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2R0N1 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 7E01457087A93978	FASTA	3,969	431,726
	10 20 30 40 50 60 MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG PGAPPSPPAV 70 80 90 100 110 120 AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS SGPALLRVGP GFDAALQVSA 130 140 150 160 170 180 AIGTNLRRFR AVFGESGGGG GSGEDEQFLG FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR 190 200 210 220 230 240 SGSDRNSAIL SDPSVFSPLN KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD 250 260 270 280 290 300 ISELPKGNKE DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV 310 320 330 340 350 360 RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ SPRRIKPVRI 370 380 390 400 410 420 IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK TQVKNIRQFI MPVVSAISSR 430 440 450 460 470 480 IIKTPRRFIE DEDYDPPIKI ARLESTPNSR FSAPSCGSSE KSSAASQHSS QMSSDSSRSS 490 500 510 520 530 540 SPSVDTSTDS QASEEIQVLP EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS 550 560 570 580 590 600 RTTKKLSTLQ SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS 610 620 630 640 650 660 TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN FRPPPLTPED 670 680 690 700 710 720 VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP RFTPSEAHSR IFESVTLPSN 730 740 750 760 770 780 RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS PSHSMRTRSG RLSTSELSPL TPPSSVSSSL 790 800 810 820 830 840 SISVSPLATS ALNPTFTFPS HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT 850 860 870 880 890 900 PGSQTERGRN KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ 910 920 930 940 950 960 SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL GDTTAVKTKI 970 980 990 1000 1010 1020 LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK HSTSSIGSML AQADKLPMTD 1030 1040 1050 1060 1070 1080 KRVASLLKKA KAQLCKIEKS KSLKQTDQPK AQGQESDSSE TSVRGPRIKH VCRRAAVALG 1090 1100 1110 1120 1130 1140 RKRAVFPDDM PTLSALPWEE REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA 1150 1160 1170 1180 1190 1200 PQEPPVKKGR RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM 1210 1220 1230 1240 1250 1260 PSKAYLQKQA KAVKKKEKKS KTSEKKDSKD SSVVKNVVDS SQKPTPSARE DPAPKKSSSE 1270 1280 1290 1300 1310 1320 PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ PALVIPPQPP TTGPPRKEVP 1330 1340 1350 1360 1370 1380 KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK QENAGTLNIL 1390 1400 1410 1420 1430 1440 STLSNGNSSK QKIPADGVHR IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS 1450 1460 1470 1480 1490 1500 GHVEFVYCQV CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK 1510 1520 1530 1540 1550 1560 CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS HDFSLCHDCA 1570 1580 1590 1600 1610 1620 KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE NLSDEMYEIL SNLPESVAYT 1630 1640 1650 1660 1670 1680 CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP DLNPETEESI 1690 1700 1710 1720 1730 1740 PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY TSVLEFSDDI VKIIQAAINS 1750 1760 1770 1780 1790 1800 DGGQPEIKKA NSMVKSFFIR QMERVFPWFS VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH 1810 1820 1830 1840 1850 1860 NYAQWQEREE NSHTEQPPLM KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE 1870 1880 1890 1900 1910 1920 LNPPPGIEDN RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN 1930 1940 1950 1960 1970 1980 VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK KVYCQRHRDL 1990 2000 2010 2020 2030 2040 IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH MMIGSMTIDC LGILNDLSDC 2050 2060 2070 2080 2090 2100 EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK IVECRPPVVE PDINSTVEHD ENRTIAHSPT 2110 2120 2130 2140 2150 2160 SFTESSSKES QNTAEIISPP SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR 2170 2180 2190 2200 2210 2220 PLPSAGSPTP TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS 2230 2240 2250 2260 2270 2280 RNNVSSVSTI GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV VTVGNKNSHL 2290 2300 2310 2320 2330 2340 DGSSSSEMKQ SSASDLASKS SSLKGEKTKV LSSKSSEGSA HNVAYPGIPK LAPQVHNTTS 2350 2360 2370 2380 2390 2400 RELNVSKIGS FAEPSSVSFS SKEALSFPHL HLRGQRNDRD QHTDSTQSAN SSADEDTEVK 2410 2420 2430 2440 2450 2460 TLKLSGMSNR SSIINEHMGS SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL 2470 2480 2490 2500 2510 2520 KPEFMDEVLT PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV 2530 2540 2550 2560 2570 2580 KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV AQPSPNNTSC 2590 2600 2610 2620 2630 2640 QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS ARARSNMFFG LTPLYGVRSY 2650 2660 2670 2680 2690 2700 GEEDIPFYSS STGKKRGKRS AEGQVDGADD LSTSDEDDLY YYNFTRTVIS SGGEERLASH 2710 2720 2730 2740 2750 2760 NLFREEEQCD LPKISQLDGV DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED 2770 2780 2790 2800 2810 2820 AGEKDHVTKS SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL 2830 2840 2850 2860 2870 2880 LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS SSELLNLGEG 2890 2900 2910 2920 2930 2940 LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ FELPLELPSD LSVLTTRSPT 2950 2960 2970 2980 2990 3000 VPSQNPSRLA VISDSGEKRV TITEKSVASS EGDPALLSPG VDPTPEGHMT PDHFIQGHMD 3010 3020 3030 3040 3050 3060 ADHISSPPCG SVEQGHGNNQ DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS 3070 3080 3090 3100 3110 3120 NAAVQTTPPH LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS 3130 3140 3150 3160 3170 3180 VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ SSFPPNISNP 3190 3200 3210 3220 3230 3240 PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK RPISRLQTRK NKKLAPSSTP 3250 3260 3270 3280 3290 3300 SNIAPSDVVS NMTLINFTPS QLPNHPSLLD LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP 3310 3320 3330 3340 3350 3360 LLPQSVGGTA ATAAGTSTIS QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG 3370 3380 3390 3400 3410 3420 HVTLTNPRLL GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAM 3430 3440 3450 3460 3470 3480 TAASSICVLP STQTTGITAA SPSGEADEHY QLQHVNQLLA SKTGIHSSQR DLDSASGPQV 3490 3500 3510 3520 3530 3540 SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS SGQRSASPSV PGPTKPKPKT 3550 3560 3570 3580 3590 3600 KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP DQETTSLTSG TGTPGAEAEQ QDTASVEQSS 3610 3620 3630 3640 3650 3660 QKECGQPAGQ VAVLPEVQVT QNPANEQEST EPKTVEEEES NFSSPLMLWL QQEQKRKESI 3670 3680 3690 3700 3710 3720 TEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML 3730 3740 3750 3760 3770 3780 GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL RKSAFDMFNF 3790 3800 3810 3820 3830 3840 LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG 3850 3860 3870 3880 3890 3900 RGLFCKRNID AGEMVIEYAG NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN 3910 3920 3930 3940 3950 3960 AARFINHSCE PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG AKKCRKFLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACZ03080830 Genomic DNA. No translation available. AACZ03080831 Genomic DNA. No translation available. AACZ03080832 Genomic DNA. No translation available. AACZ03080833 Genomic DNA. No translation available. AACZ03080834 Genomic DNA. No translation available. AACZ03080835 Genomic DNA. No translation available. AACZ03080836 Genomic DNA. No translation available.
RefSeq	XP_508792.2. XM_508792.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000044431; ENSPTRP00000040970; ENSPTRG00000004344.
GeneID	451587.
KEGG	ptr:451587.
Organism-specific databases
CTD	4297.
Phylogenomic databases
GeneTree	ENSGT00690000101661.
KO	K09186.
OMA	QYFSSAK.
Family and domain databases
Gene3D	1.20.920.10. 1 hit. 3.30.40.10. 2 hits.
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR001487. Bromodomain. IPR003889. FYrich_C. IPR003888. FYrich_N. IPR016569. MeTrfase_trithorax. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR002857. Znf_CXXC. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF05965. FYRC. 1 hit. PF05964. FYRN. 1 hit. PF00628. PHD. 2 hits. PF00856. SET. 1 hit. PF02008. zf-CXXC. 1 hit. [Graphical view]
PIRSF	PIRSF010354. Methyltransferase_trithorax. 1 hit.
SMART	SM00384. AT_hook. 3 hits. SM00297. BROMO. 1 hit. SM00542. FYRC. 1 hit. SM00541. FYRN. 1 hit. SM00249. PHD. 4 hits. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit. SSF57903. FYVE_PHD_ZnF. 2 hits.
PROSITE	PS50014. BROMODOMAIN_2. 1 hit. PS51543. FYRC. 1 hit. PS51542. FYRN. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS51058. ZF_CXXC. 1 hit. PS50016. ZF_PHD_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2R0N1_PANTR

Accession

Primary (citable) accession number: H2R0N1

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)