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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone methyltransferase.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei3842S-adenosyl-L-methionineUniRule annotation1
Binding sitei3844S-adenosyl-L-methionineUniRule annotation1
Binding sitei3886S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3912ZincUniRule annotation1
Metal bindingi3960ZincUniRule annotation1
Binding sitei3961S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3962ZincUniRule annotation1
Metal bindingi3967ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1147 – 1195CXXC-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
Name:KMT2AImported
ORF Names:CK820_G0015728Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:7657. KMT2A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiH2R0N1.

Expressioni

Gene expression databases

BgeeiENSPTRG00000004344.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000040970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1147 – 1195CXXC-typeInterPro annotationAdd BLAST49
Domaini1431 – 1482PHD-typeInterPro annotationAdd BLAST52
Domaini1479 – 1533PHD-typeInterPro annotationAdd BLAST55
Domaini1566 – 1630PHD-typeInterPro annotationAdd BLAST65
Domaini1706 – 1751BromoInterPro annotationAdd BLAST46
Domaini1873 – 1981PHD-typeInterPro annotationAdd BLAST109
Domaini2021 – 2077FYR N-terminalInterPro annotationAdd BLAST57
Domaini3669 – 3750FYR C-terminalInterPro annotationAdd BLAST82
Domaini3832 – 3948SETInterPro annotationAdd BLAST117
Domaini3956 – 3972Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3909 – 3910S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili373 – 393Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1147 – 1195CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00760000119228.
InParanoidiH2R0N1.
OMAiRIMSPMR.
OrthoDBiEOG091G001P.
TreeFamiTF319820.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR034732. EPHD.
IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR037927. KMT2A.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR22884:SF387. PTHR22884:SF387. 1 hit.
PfamiView protein in Pfam
PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
PF02008. zf-CXXC. 1 hit.
PIRSFiPIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiView protein in PROSITE
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS50016. ZF_PHD_2. 3 hits.

Sequencei

Sequence statusi: Complete.

H2R0N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS
110 120 130 140 150
SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGEDEQFLG
160 170 180 190 200
FGSDEEVRVR SPTRSPSVKT SPRKPRGRPR SGSDRNSAIL SDPSVFSPLN
210 220 230 240 250
KSETKSGDKI KKKDSKSIEK KRGRPPTFPG VKIKITHGKD ISELPKGNKE
260 270 280 290 300
DSLKKIKRTP SATFQQATKI KKLRAGKLSP LKSKFKTGKL QIGRKGVQIV
310 320 330 340 350
RRRGRPPSTE RIKTPSGLLI NSELEKPQKV RKDKEGTPPL TKEDKTVVRQ
360 370 380 390 400
SPRRIKPVRI IPSSKRTDAT IAKQLLQRAK KGAQKKIEKE AAQLQGRKVK
410 420 430 440 450
TQVKNIRQFI MPVVSAISSR IIKTPRRFIE DEDYDPPIKI ARLESTPNSR
460 470 480 490 500
FSAPSCGSSE KSSAASQHSS QMSSDSSRSS SPSVDTSTDS QASEEIQVLP
510 520 530 540 550
EERSDTPEVH PPLPISQSPE NESNDRRSRR YSVSERSFGS RTTKKLSTLQ
560 570 580 590 600
SAPQQQTSSS PPPPLLTPPP PLQPASSISD HTPWLMPPTI PLASPFLPAS
610 620 630 640 650
TAPMQGKRKS ILREPTFRWT SLKHSRSEPQ YFSSAKYAKE GLIRKPIFDN
660 670 680 690 700
FRPPPLTPED VGFASGFSAS GTAASARLFS PLHSGTRFDM HKRSPLLRAP
710 720 730 740 750
RFTPSEAHSR IFESVTLPSN RTSAGTSSSG VSNRKRKRKV FSPIRSEPRS
760 770 780 790 800
PSHSMRTRSG RLSTSELSPL TPPSSVSSSL SISVSPLATS ALNPTFTFPS
810 820 830 840 850
HSLTQSGESA EKNQRPRKQT SAPAEPFSSS SPTPLFPWFT PGSQTERGRN
860 870 880 890 900
KDKAPEELSK DRDADKSVEK DKSRERDRER EKENKRESRK EKRKKGSEIQ
910 920 930 940 950
SSSALYPVGR VSKEKVVGED VATSSSAKKA TGRKKSSSHD SGTDITSVTL
960 970 980 990 1000
GDTTAVKTKI LIKKGRGNLE KTNLDLGPTA PSLEKEKTLC LSTPSSSTVK
1010 1020 1030 1040 1050
HSTSSIGSML AQADKLPMTD KRVASLLKKA KAQLCKIEKS KSLKQTDQPK
1060 1070 1080 1090 1100
AQGQESDSSE TSVRGPRIKH VCRRAAVALG RKRAVFPDDM PTLSALPWEE
1110 1120 1130 1140 1150
REKILSSMGN DDKSSIAGSE DAEPLAPPIK PIKPVTRNKA PQEPPVKKGR
1160 1170 1180 1190 1200
RSRRCGQCPG CQVPEDCGVC TNCLDKPKFG GRNIKKQCCK MRKCQNLQWM
1210 1220 1230 1240 1250
PSKAYLQKQA KAVKKKEKKS KTSEKKDSKD SSVVKNVVDS SQKPTPSARE
1260 1270 1280 1290 1300
DPAPKKSSSE PPPRKPVEEK SEEGNVSAPG PESKQATTPA SRKSSKQVSQ
1310 1320 1330 1340 1350
PALVIPPQPP TTGPPRKEVP KTTPSEPKKK QPPPPESGPE QSKQKKVAPR
1360 1370 1380 1390 1400
PSIPVKQKPK EKEKPPPVNK QENAGTLNIL STLSNGNSSK QKIPADGVHR
1410 1420 1430 1440 1450
IRVDFKEDCE AENVWEMGGL GILTSVPITP RVVCFLCASS GHVEFVYCQV
1460 1470 1480 1490 1500
CCEPFHKFCL EENERPLEDQ LENWCCRRCK FCHVCGRQHQ ATKQLLECNK
1510 1520 1530 1540 1550
CRNSYHPECL GPNYPTKPTK KKKVWICTKC VRCKSCGSTT PGKGWDAQWS
1560 1570 1580 1590 1600
HDFSLCHDCA KLFAKGNFCP LCDKCYDDDD YESKMMQCGK CDRWVHSKCE
1610 1620 1630 1640 1650
NLSGTEDEMY EILSNLPESV AYTCVNCTER HPAEWRLALE KELQISLKQV
1660 1670 1680 1690 1700
LTALLNSRTT SHLLRYRQAA KPPDLNPETE ESIPSRSSPE GPDPPVLTEV
1710 1720 1730 1740 1750
SKQDDQQPLD LEGVKRKMDQ GNYTSVLEFS DDIVKIIQAA INSDGGQPEI
1760 1770 1780 1790 1800
KKANSMVKSF FIRQMERVFP WFSVKKSRFW EPNKVSSNSG MLPNAVLPPS
1810 1820 1830 1840 1850
LDHNYAQWQE REENSHTEQP PLMKKIIPAP KPKGPGEPDS PTPLHPPTPP
1860 1870 1880 1890 1900
ILSTDRSRED SPELNPPPGI EDNRQCALCL TYGDDSANDA GRLLYIGQNE
1910 1920 1930 1940 1950
WTHVNCALWS AEVFEDDDGS LKNVHMAVIR GKQLRCEFCQ KPGATVGCCL
1960 1970 1980 1990 2000
TSCTSNYHFM CSRAKNCVFL DDKKVYCQRH RDLIKGEVVP ENGFEVFRRV
2010 2020 2030 2040 2050
FVDFEGISLR RKFLNGLEPE NIHMMIGSMT IDCLGILNDL SDCEDKLFPI
2060 2070 2080 2090 2100
GYQCSRVYWS TTDARKRCVY TCKIVECRPP VVEPDINSTV EHDENRTIAH
2110 2120 2130 2140 2150
SPTSFTESSS KESQNTAEII SPPSPDRPPH SQTSGSCYYH VISKVPRIRT
2160 2170 2180 2190 2200
PSYSPTQRSP GCRPLPSAGS PTPTTHEIVT VGDPLLSSGL RSIGSRRHST
2210 2220 2230 2240 2250
SSLSPQRSKL RIMSPMRTGN TYSRNNVSSV STIGTATDLE SSAKVVDHVL
2260 2270 2280 2290 2300
GPLNSSTSLG QNTSTSSNLQ RTVVTVGNKN SHLDGSSSSE MKQSSASDLA
2310 2320 2330 2340 2350
SKSSSLKGEK TKVLSSKSSE GSAHNVAYPG IPKLAPQVHN TTSRELNVSK
2360 2370 2380 2390 2400
IGSFAEPSSV SFSSKEALSF PHLHLRGQRN DRDQHTDSTQ SANSSADEDT
2410 2420 2430 2440 2450
EVKTLKLSGM SNRSSIINEH MGSSSRDRRQ KGKKSCKETF KEKHSSKSFL
2460 2470 2480 2490 2500
EPGQVTTGEE GNLKPEFMDE VLTPEYMGQR PCNNVSSDKI GDKGLSMPGV
2510 2520 2530 2540 2550
PKAPPMQVEG SAKELQAPRK RTVKVTLTPL KMENESQSKN ALKESSPASP
2560 2570 2580 2590 2600
LQIESTSPTE PISASENPGD GPVAQPSPNN TSCQDSQSNN YQNLPVQDRN
2610 2620 2630 2640 2650
LMLPDGPKPQ EDGSFKRRYP RRSARARSNM FFGLTPLYGV RSYGEEDIPF
2660 2670 2680 2690 2700
YSSSTGKKRG KRSAEGQVDG ADDLSTSDED DLYYYNFTRT VISSGGEERL
2710 2720 2730 2740 2750
ASHNLFREEE QCDLPKISQL DGVDDGTESD TSVTATTRKS SQIPKRNGKE
2760 2770 2780 2790 2800
NGTENLKIDR PEDAGEKDHV TKSSVGHKNE PKMDNCHSVS RVKTQGQDSL
2810 2820 2830 2840 2850
EAQLSSLESS RRVHTSTPSD KNLLDTYNTE LLKSDSDNNN SDDCGNILPS
2860 2870 2880 2890 2900
DIMDFVLKNT PSMQALGESP ESSSSELLNL GEGLGLDSNR EKDMGLFEVF
2910 2920 2930 2940 2950
SQQLPTTEPV DSSVSSSISA EEQFELPLEL PSDLSVLTTR SPTVPSQNPS
2960 2970 2980 2990 3000
RLAVISDSGE KRVTITEKSV ASSEGDPALL SPGVDPTPEG HMTPDHFIQG
3010 3020 3030 3040 3050
HMDADHISSP PCGSVEQGHG NNQDLTRNSS TPGLQVPVSP TVPIQNQKYV
3060 3070 3080 3090 3100
PNSTDSPGPS QISNAAVQTT PPHLKPATEK LIVVNQNMQP LYVLQTLPNG
3110 3120 3130 3140 3150
VTQKIQLTSS VSSTPSVMET NTSVLGPMGG GLTLTTGLNP SLPTSQSLFP
3160 3170 3180 3190 3200
SASKGLLPMS HHQHLHSFPA ATQSSFPPNI SNPPSGLLIG VQPPPDPQLL
3210 3220 3230 3240 3250
VSESSQRTDL STTVATPSSG LKKRPISRLQ TRKNKKLAPS STPSNIAPSD
3260 3270 3280 3290 3300
VVSNMTLINF TPSQLPNHPS LLDLGSLNTS SHRTVPNIIK RSKSSIMYFE
3310 3320 3330 3340 3350
PAPLLPQSVG GTAATAAGTS TISQDTSHLT SGSVSGLASS SSVLNVVSMQ
3360 3370 3380 3390 3400
TTTTPTSSAS VPGHVTLTNP RLLGTPDIGS ISNLLIKASQ QSLGIQDQPV
3410 3420 3430 3440 3450
ALPPSSGMFP QLGTSQTPST AAMTAASSIC VLPSTQTTGI TAASPSGEAD
3460 3470 3480 3490 3500
EHYQLQHVNQ LLASKTGIHS SQRDLDSASG PQVSNFTQTV DAPNSMGLEQ
3510 3520 3530 3540 3550
NKALSSAVQA SPTSPGGSPS SPSSGQRSAS PSVPGPTKPK PKTKRFQLPL
3560 3570 3580 3590 3600
DKGNGKKHKV SHLRTSSSEA HIPDQETTSL TSGTGTPGAE AEQQDTASVE
3610 3620 3630 3640 3650
QSSQKECGQP AGQVAVLPEV QVTQNPANEQ ESTEPKTVEE EESNFSSPLM
3660 3670 3680 3690 3700
LWLQQEQKRK ESITEKKPKK GLVFEISSDD GFQICAESIE DAWKSLTDKV
3710 3720 3730 3740 3750
QEARSNARLK QLSFAGVNGL RMLGILHDAV VFLIEQLSGA KHCRNYKFRF
3760 3770 3780 3790 3800
HKPEEANEPP LNPHGSARAE VHLRKSAFDM FNFLASKHRQ PPEYNPNDEE
3810 3820 3830 3840 3850
EEEVQLKSAR RATSMDLPMP MRFRHLKKTS KEAVGVYRSP IHGRGLFCKR
3860 3870 3880 3890 3900
NIDAGEMVIE YAGNVIRSIQ TDKREKYYDS KGIGCYMFRI DDSEVVDATM
3910 3920 3930 3940 3950
HGNAARFINH SCEPNCYSRV INIDGQKHIV IFAMRKIYRG EELTYDYKFP
3960 3970
IEDASNKLPC NCGAKKCRKF LN
Length:3,972
Mass (Da):432,014
Last modified:February 28, 2018 - v2
Checksum:iCC72697ED91EF287
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04006748 Genomic DNA. No translation available.
NBAG03000239 Genomic DNA. Translation: PNI66022.1.
RefSeqiXP_009422533.1. XM_009424258.2.

Genome annotation databases

EnsembliENSPTRT00000044431; ENSPTRP00000040970; ENSPTRG00000004344.
GeneIDi451587.

Similar proteinsi

Entry informationi

Entry nameiH2R0N1_PANTR
AccessioniPrimary (citable) accession number: H2R0N1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported