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Protein
Submitted name:

Enhancer of zeste homolog 2

Gene

EZH2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. core promoter binding Source: Ensembl
  3. histone-lysine N-methyltransferase activity Source: InterPro
  4. RNA binding Source: Ensembl
  5. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. cerebellar cortex development Source: Ensembl
  3. DNA methylation Source: Ensembl
  4. G1 to G0 transition Source: Ensembl
  5. histone H3-K27 methylation Source: Ensembl
  6. negative regulation of epidermal cell differentiation Source: Ensembl
  7. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  8. negative regulation of gene expression, epigenetic Source: Ensembl
  9. negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
  10. negative regulation of striated muscle cell differentiation Source: Ensembl
  11. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  12. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  13. positive regulation of MAP kinase activity Source: Ensembl
  14. positive regulation of Ras GTPase activity Source: Ensembl
  15. protein localization to chromatin Source: Ensembl
  16. regulation of cell proliferation Source: Ensembl
  17. regulation of circadian rhythm Source: Ensembl
  18. regulation of gliogenesis Source: Ensembl
  19. skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Enhancer of zeste homolog 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EZH2Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. ESC/E(Z) complex Source: Ensembl
  3. nuclear chromatin Source: Ensembl
  4. pronucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119228.
KOiK11430.
OMAiNRDDKES.
OrthoDBiEOG7VB2DR.
TreeFamiTF314509.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2QVK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
60 70 80 90 100
ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT
110 120 130 140 150
LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI
160 170 180 190 200
KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ
210 220 230 240 250
KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ
260 270 280 290 300
QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH
310 320 330 340 350
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP
360 370 380 390 400
GGRRRGRLPN NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK
410 420 430 440 450
KDETSSSSEA NSRCQTPIKM KPNIEPPENV EWSGAEASMF RVLIGTYYDN
460 470 480 490 500
FCAIARLIGT KTCRQVYEFR VKESSIIAPA PAEDVDTPPR KKKRKHRLWA
510 520 530 540 550
AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ NFCEKFCQCS
560 570 580 590 600
SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS
610 620 630 640 650
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE
660 670 680 690 700
ADRRGKVYDK YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM
710 720 730 740
MVNGDHRIGI FAKRAIQTGE ELFFDYRYSQ ADALKYVGIE REMEIP
Length:746
Mass (Da):85,363
Last modified:March 21, 2012 - v1
Checksum:i1B5029EB9D509BE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC188684 Genomic DNA. No translation available.
AC192396 Genomic DNA. No translation available.
GABF01003205 mRNA. Translation: JAA18940.1.
GABE01007991 mRNA. Translation: JAA36748.1.
RefSeqiXP_001166174.2. XM_001166174.3.

Genome annotation databases

EnsembliENSPTRT00000036735; ENSPTRP00000033970; ENSPTRG00000019837.
GeneIDi745437.
KEGGiptr:745437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC188684 Genomic DNA. No translation available.
AC192396 Genomic DNA. No translation available.
GABF01003205 mRNA. Translation: JAA18940.1.
GABE01007991 mRNA. Translation: JAA36748.1.
RefSeqiXP_001166174.2. XM_001166174.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000036735; ENSPTRP00000033970; ENSPTRG00000019837.
GeneIDi745437.
KEGGiptr:745437.

Organism-specific databases

CTDi2146.

Phylogenomic databases

GeneTreeiENSGT00760000119228.
KOiK11430.
OMAiNRDDKES.
OrthoDBiEOG7VB2DR.
TreeFamiTF314509.

Family and domain databases

InterProiIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Skeletal muscleImported and Smooth vascularImported.

Entry informationi

Entry nameiH2QVK6_PANTR
AccessioniPrimary (citable) accession number: H2QVK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: March 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.