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H2QVK6 (H2QVK6_PANTR) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length746 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains SET domain. SAAS SAAS001214

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG1 to G0 transition

Inferred from electronic annotation. Source: Ensembl

cerebellar cortex development

Inferred from electronic annotation. Source: Ensembl

histone H3-K27 methylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

negative regulation of epidermal cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression, epigenetic

Inferred from electronic annotation. Source: Ensembl

negative regulation of retinoic acid receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of striated muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription elongation from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of Ras GTPase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of gliogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentESC/E(Z) complex

Inferred from electronic annotation. Source: Ensembl

pronucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from electronic annotation. Source: Ensembl

core promoter binding

Inferred from electronic annotation. Source: Ensembl

histone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H2QVK6 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 1B5029EB9D509BE5

FASTA74685,363
        10         20         30         40         50         60 
MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 

        70         80         90        100        110        120 
KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 

       130        140        150        160        170        180 
MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 

       190        200        210        220        230        240 
YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL 

       250        260        270        280        290        300 
KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 

       310        320        330        340        350        360 
ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN 

       370        380        390        400        410        420 
NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM 

       430        440        450        460        470        480 
KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA 

       490        500        510        520        530        540 
PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ 

       550        560        570        580        590        600 
NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 

       610        620        630        640        650        660 
CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK 

       670        680        690        700        710        720 
YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE 

       730        740 
ELFFDYRYSQ ADALKYVGIE REMEIP 

« Hide

References

« Hide 'large scale' references
[1]"Initial sequence of the chimpanzee genome and comparison with the human genome."
Chimpanzee sequencing and analysis consortium
Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
[3]"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Skeletal muscle EMBL JAA36748.1 and Smooth vascular EMBL JAA18940.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC188684 Genomic DNA. No translation available.
AC192396 Genomic DNA. No translation available.
GABF01003205 mRNA. Translation: JAA18940.1.
GABE01007991 mRNA. Translation: JAA36748.1.
RefSeqXP_001166174.2. XM_001166174.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000036735; ENSPTRP00000033970; ENSPTRG00000019837.
GeneID745437.
KEGGptr:745437.

Organism-specific databases

CTD2146.

Phylogenomic databases

GeneTreeENSGT00740000115009.
KOK11430.
OMANRDDKES.
OrthoDBEOG7VB2DR.
TreeFamTF314509.

Family and domain databases

InterProIPR026489. CXC_dom.
IPR021654. EZH2_WD-Binding.
IPR001005. SANT/Myb.
IPR001214. SET_dom.
[Graphical view]
PfamPF11616. EZH2_WD-Binding. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTSM00717. SANT. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51633. CXC. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2QVK6_PANTR
AccessionPrimary (citable) accession number: H2QVK6
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 16, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)