H2QVK6 (H2QVK6_PANTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Enhancer of zeste homolog 2 EMBL JAA18940.1

Submitted name:
Uncharacterized protein Ensembl ENSPTRP00000033970

Gene names

Name:	ENSG00000106462 Ensembl ENSPTRP00000033970
Synonyms:	EZH2 EMBL JAA18940.1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000033970

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	746 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SET domain. SAAS SAAS001214 RuleBase RU004538

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC
Molecular_function	chromatin binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2QVK6 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 1B5029EB9D509BE5	FASTA	746	85,363
	10 20 30 40 50 60 MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW 70 80 90 100 110 120 KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF 130 140 150 160 170 180 MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ 190 200 210 220 230 240 YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL 250 260 270 280 290 300 KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 310 320 330 340 350 360 ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN 370 380 390 400 410 420 NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM 430 440 450 460 470 480 KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA 490 500 510 520 530 540 PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ 550 560 570 580 590 600 NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 610 620 630 640 650 660 CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK 670 680 690 700 710 720 YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE 730 740 ELFFDYRYSQ ADALKYVGIE REMEIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
[3]	"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences." Maudhoo M.D., Meehan D.T., Norgren R.B.Jr. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skeletal muscle EMBL JAA36748.1 and Smooth vascular EMBL JAA18940.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC188684 Genomic DNA. No translation available. AC192396 Genomic DNA. No translation available. GABF01003205 mRNA. Translation: JAA18940.1. GABE01007991 mRNA. Translation: JAA36748.1.
RefSeq	XP_001166174.2. XM_001166174.2.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	H2QVK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000036735; ENSPTRP00000033970; ENSPTRG00000019837.
GeneID	745437.
KEGG	ptr:745437.
Organism-specific databases
CTD	2146.
Phylogenomic databases
GeneTree	ENSGT00700000104213.
KO	K11430.
OMA	NRDDKES.
Family and domain databases
InterPro	IPR026489. CXC_dom. IPR021654. EZH2_WD-Binding. IPR001005. SANT/Myb. IPR001214. SET_dom. [Graphical view]
Pfam	PF11616. EZH2_WD-Binding. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00717. SANT. 2 hits. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51633. CXC. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2QVK6_PANTR

Accession

Primary (citable) accession number: H2QVK6

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	May 1, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)