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H2QVK6

- H2QVK6_PANTR

UniProt

H2QVK6 - H2QVK6_PANTR

Protein
Submitted name:

Enhancer of zeste homolog 2

Gene

EZH2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. core promoter binding Source: Ensembl
    3. histone-lysine N-methyltransferase activity Source: InterPro
    4. RNA binding Source: Ensembl
    5. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. cerebellar cortex development Source: Ensembl
    2. G1 to G0 transition Source: Ensembl
    3. histone H3-K27 methylation Source: Ensembl
    4. negative regulation of epidermal cell differentiation Source: Ensembl
    5. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    6. negative regulation of gene expression, epigenetic Source: Ensembl
    7. negative regulation of retinoic acid receptor signaling pathway Source: Ensembl
    8. negative regulation of striated muscle cell differentiation Source: Ensembl
    9. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
    10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    12. positive regulation of MAP kinase activity Source: Ensembl
    13. positive regulation of Ras GTPase activity Source: Ensembl
    14. regulation of cell proliferation Source: Ensembl
    15. regulation of gliogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Enhancer of zeste homolog 2Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:EZH2Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. ESC/E(Z) complex Source: Ensembl
    2. pronucleus Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliH2QVK6.
    SMRiH2QVK6. Positions 40-68, 520-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115009.
    KOiK11430.
    OMAiNRDDKES.
    OrthoDBiEOG7VB2DR.
    TreeFamiTF314509.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2QVK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL    50
    ERTEILNQEW KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT 100
    LNAVASVPIM YSWSPLQQNF MVEDETVLHN IPYMGDEVLD QDGTFIEELI 150
    KNYDGKVHGD RECGFINDEI FVELVNALGQ YNDDDDDDDG DDPEEREEKQ 200
    KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL KEKYKELTEQ 250
    QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH 300
    ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP 350
    GGRRRGRLPN NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK 400
    KDETSSSSEA NSRCQTPIKM KPNIEPPENV EWSGAEASMF RVLIGTYYDN 450
    FCAIARLIGT KTCRQVYEFR VKESSIIAPA PAEDVDTPPR KKKRKHRLWA 500
    AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ NFCEKFCQCS 550
    SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS 600
    CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE 650
    ADRRGKVYDK YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM 700
    MVNGDHRIGI FAKRAIQTGE ELFFDYRYSQ ADALKYVGIE REMEIP 746
    Length:746
    Mass (Da):85,363
    Last modified:March 21, 2012 - v1
    Checksum:i1B5029EB9D509BE5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC188684 Genomic DNA. No translation available.
    AC192396 Genomic DNA. No translation available.
    GABF01003205 mRNA. Translation: JAA18940.1.
    GABE01007991 mRNA. Translation: JAA36748.1.
    RefSeqiXP_001166174.2. XM_001166174.2.

    Genome annotation databases

    EnsembliENSPTRT00000036735; ENSPTRP00000033970; ENSPTRG00000019837.
    GeneIDi745437.
    KEGGiptr:745437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC188684 Genomic DNA. No translation available.
    AC192396 Genomic DNA. No translation available.
    GABF01003205 mRNA. Translation: JAA18940.1 .
    GABE01007991 mRNA. Translation: JAA36748.1 .
    RefSeqi XP_001166174.2. XM_001166174.2.

    3D structure databases

    ProteinModelPortali H2QVK6.
    SMRi H2QVK6. Positions 40-68, 520-729.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000036735 ; ENSPTRP00000033970 ; ENSPTRG00000019837 .
    GeneIDi 745437.
    KEGGi ptr:745437.

    Organism-specific databases

    CTDi 2146.

    Phylogenomic databases

    GeneTreei ENSGT00740000115009.
    KOi K11430.
    OMAi NRDDKES.
    OrthoDBi EOG7VB2DR.
    TreeFami TF314509.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Skeletal muscleImported and Smooth vascularImported.

    Entry informationi

    Entry nameiH2QVK6_PANTR
    AccessioniPrimary (citable) accession number: H2QVK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3