ID   H2QT71_PANTR            Unreviewed;       172 AA.
AC   H2QT71; A0A2J8P104;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Glutathione S-transferase {ECO:0000256|RuleBase:RU003494};
DE            EC=2.5.1.18 {ECO:0000256|RuleBase:RU003494};
GN   Name=GSTA3 {ECO:0000313|Ensembl:ENSPTRP00000031238.3,
GN   ECO:0000313|VGNC:VGNC:11091};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000031238.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000031238.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000031238.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + RX = a halide anion + an S-substituted
CC         glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:90779; EC=2.5.1.18;
CC         Evidence={ECO:0000256|RuleBase:RU003494};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC       {ECO:0000256|ARBA:ARBA00011055, ECO:0000256|RuleBase:RU003494}.
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DR   EMBL; AACZ04022933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04022934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04022935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016811161.1; XM_016955672.1.
DR   RefSeq; XP_016811162.1; XM_016955673.1.
DR   AlphaFoldDB; H2QT71; -.
DR   STRING; 9598.ENSPTRP00000075199; -.
DR   Ensembl; ENSPTRT00000033799.3; ENSPTRP00000031238.3; ENSPTRG00000032453.3.
DR   GeneID; 462770; -.
DR   KEGG; ptr:462770; -.
DR   CTD; 2940; -.
DR   VGNC; VGNC:11091; GSTA3.
DR   eggNOG; KOG1695; Eukaryota.
DR   GeneTree; ENSGT00940000164319; -.
DR   HOGENOM; CLU_039475_4_0_1; -.
DR   OMA; FTEMIMN; -.
DR   OrthoDB; 3412208at2759; -.
DR   TreeFam; TF105321; -.
DR   Proteomes; UP000002277; Chromosome 6.
DR   Bgee; ENSPTRG00000032453; Expressed in testis and 3 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03208; GST_C_Alpha; 1.
DR   Gene3D; 1.20.1050.130; -; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR003080; GST_alpha.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR11571:SF257; GLUTATHIONE S-TRANSFERASE A3; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01266; GSTRNSFRASEA.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transferase {ECO:0000256|RuleBase:RU003494}.
FT   DOMAIN          1..33
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          35..157
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   172 AA;  19715 MW;  4F5F107BA5495C8D CRC64;
     MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP
     LCRPEEKDAK IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL
     DSSLISSFPL LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF
//