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H2QRN6 (H2QRN6_PANTR) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913

Subcellular location

Nucleus By similarity PIRNR PIRNR037913.

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
   Biological processTranscription
Transcription regulation PIRNR PIRNR037913
   Cellular componentNucleus PIRNR PIRNR037913
   Molecular functionChromatin regulator PIRNR PIRNR037913
Hydrolase PIRNR PIRNR037913 SAAS SAAS000286
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcircadian regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

negative regulation of JNK cascade

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

spindle assembly

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

spindle microtubule

Inferred from electronic annotation. Source: Ensembl

transcriptional repressor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

chromatin DNA binding

Inferred from electronic annotation. Source: Ensembl

transcription corepressor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H2QRN6 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 94485C1EBDCF5AD0

FASTA42848,848
        10         20         30         40         50         60 
MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 

        70         80         90        100        110        120 
FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 

       130        140        150        160        170        180 
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 

       190        200        210        220        230        240 
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 

       250        260        270        280        290        300 
NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 

       310        320        330        340        350        360 
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 

       370        380        390        400        410        420 
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 


DKESDVEI 

« Hide

References

« Hide 'large scale' references
[1]"Initial sequence of the chimpanzee genome and comparison with the human genome."
Chimpanzee sequencing and analysis consortium
Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
[3]"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Adipose stromal EMBL JAA10240.1, Skeletal muscle EMBL JAA34931.1, Skin EMBL JAA23955.1 and Smooth vascular EMBL JAA14201.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACZ03038989 Genomic DNA. No translation available.
GABC01001098 mRNA. Translation: JAA10240.1.
GABF01007944 mRNA. Translation: JAA14201.1.
GABD01009145 mRNA. Translation: JAA23955.1.
GABE01009808 mRNA. Translation: JAA34931.1.
RefSeqXP_001151495.1. XM_001151495.3.

3D structure databases

ProteinModelPortalH2QRN6.
SMRH2QRN6. Positions 2-370.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000032099; ENSPTRP00000029652; ENSPTRG00000017348.
GeneID738624.
KEGGptr:738624.

Organism-specific databases

CTD8841.

Phylogenomic databases

GeneTreeENSGT00530000062889.
KOK11404.
OMANFHYGPG.
OrthoDBEOG7DNNTW.
TreeFamTF352182.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameH2QRN6_PANTR
AccessionPrimary (citable) accession number: H2QRN6
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)