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H2QRN6

- H2QRN6_PANTR

UniProt

H2QRN6 - H2QRN6_PANTR

Protein

Histone deacetylase

Gene

HDAC3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    6. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. circadian regulation of gene expression Source: Ensembl
    2. negative regulation of JNK cascade Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of mitotic cell cycle Source: Ensembl
    5. regulation of multicellular organism growth Source: Ensembl
    6. spindle assembly Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    Name:HDAC3Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 5

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. spindle microtubule Source: Ensembl
    3. transcriptional repressor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000062889.
    KOiK11404.
    OMAiNFHYGPG.
    OrthoDBiEOG7DNNTW.
    TreeFamiTF352182.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    H2QRN6-1 [UniParc]FASTAAdd to Basket

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    MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP    50
    YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL 100
    FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI 150
    VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF 200
    PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT 250
    CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
    RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN 350
    SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP 400
    EENYSRPEAP NEFYDGDHDN DKESDVEI 428
    Length:428
    Mass (Da):48,848
    Last modified:March 21, 2012 - v1
    Checksum:i94485C1EBDCF5AD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03038989 Genomic DNA. No translation available.
    GABC01001098 mRNA. Translation: JAA10240.1.
    GABF01007944 mRNA. Translation: JAA14201.1.
    GABD01009145 mRNA. Translation: JAA23955.1.
    GABE01009808 mRNA. Translation: JAA34931.1.
    RefSeqiXP_001151495.1. XM_001151495.3.

    Genome annotation databases

    EnsembliENSPTRT00000032099; ENSPTRP00000029652; ENSPTRG00000017348.
    GeneIDi738624.
    KEGGiptr:738624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03038989 Genomic DNA. No translation available.
    GABC01001098 mRNA. Translation: JAA10240.1 .
    GABF01007944 mRNA. Translation: JAA14201.1 .
    GABD01009145 mRNA. Translation: JAA23955.1 .
    GABE01009808 mRNA. Translation: JAA34931.1 .
    RefSeqi XP_001151495.1. XM_001151495.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000032099 ; ENSPTRP00000029652 ; ENSPTRG00000017348 .
    GeneIDi 738624.
    KEGGi ptr:738624.

    Organism-specific databases

    CTDi 8841.

    Phylogenomic databases

    GeneTreei ENSGT00530000062889.
    KOi K11404.
    OMAi NFHYGPG.
    OrthoDBi EOG7DNNTW.
    TreeFami TF352182.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

    Entry informationi

    Entry nameiH2QRN6_PANTR
    AccessioniPrimary (citable) accession number: H2QRN6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3