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Protein
Submitted name:

Hyperpolarization activated cyclic nucleotide gated potassium channel 1

Gene

HCN1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Hyperpolarization activated cyclic nucleotide gated potassium channel 1Imported
Gene namesi
Name:HCN1Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei137 – 161HelicalSequence analysisAdd BLAST25
Transmembranei366 – 391HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiH2QQV0.

Expressioni

Gene expression databases

BgeeiENSPTRG00000016855.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000028879.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini469 – 575Cyclic nucleotide-bindingInterPro annotationAdd BLAST107

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
GeneTreeiENSGT00900000140801.
InParanoidiH2QQV0.
OMAiHREEDMG.
OrthoDBiEOG091G0JQU.
TreeFamiTF318250.

Family and domain databases

CDDicd00038. CAP_ED. 1 hit.
Gene3Di2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR013621. Ion_trans_N.
IPR030169. K/Na_HCN1.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
PANTHERiPTHR10217:SF373. PTHR10217:SF373. 1 hit.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08412. Ion_trans_N. 1 hit.
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS00888. CNMP_BINDING_1. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.

Sequencei

Sequence statusi: Complete.

H2QQV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA
60 70 80 90 100
KEHGNSVCFK VDGGGGGGEE PAGGFEDAEG PRRQYGFMQR QFTSMLQPGV
110 120 130 140 150
NKFSLRMFGS QKAVEKEQER VKTAGFWIIH PYSDFRFYWD LIMLIMMVGN
160 170 180 190 200
LVIIPVGITF FTEQTTTPWI IFNVASDTVF LLDLIMNFRT GTVNEDSSEI
210 220 230 240 250
ILDPKVIKMN YLKSWFVVDF ISSIPVDYIF LIVEKGMDSE VYKTARALRI
260 270 280 290 300
VRFTKILSLL RLLRLSRLIR YIHQWEEIFH MTYDLASAVV RIFNLIGMML
310 320 330 340 350
LLCHWDGCLQ FLVPLLQDFP PDCWVSLNEM VNDSWGKQYS YALFKAMSHM
360 370 380 390 400
LCIGYGAQAP VSMSDLWITM LSMIVGATCY AMFVGHATAL IQSLDSSRRQ
410 420 430 440 450
YQEKYKQVEQ YMSFHKLPAD MRQKIHDYYE HRYQGKIFDE ENILNELNDP
460 470 480 490 500
LREEIVNFNC RKLVATMPLF ANADPNFVTA MLSKLRFEVF QPGDYIIREG
510 520 530 540 550
AVGKKMYFIQ HGVAGVITKS SKEMKLTDGS YFGEICLLTK GRRTASVRAD
560 570 580 590 600
TYCRLYSLSV DNFNEVLEEY PMMRRAFETV AIDRLDRIGK KNSILLQKFQ

KDL
Length:603
Mass (Da):68,482
Last modified:March 21, 2012 - v1
Checksum:iF842D65035BC06CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03043554 Genomic DNA. No translation available.
AACZ03043555 Genomic DNA. No translation available.
AACZ03043556 Genomic DNA. No translation available.
AACZ03043557 Genomic DNA. No translation available.
AACZ03043558 Genomic DNA. No translation available.
AACZ03043559 Genomic DNA. No translation available.
AACZ03043560 Genomic DNA. No translation available.
AACZ03043561 Genomic DNA. No translation available.
AACZ03043562 Genomic DNA. No translation available.
AACZ03043563 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSPTRT00000031270; ENSPTRP00000028879; ENSPTRG00000016855.

Similar proteinsi

Entry informationi

Entry nameiH2QQV0_PANTR
AccessioniPrimary (citable) accession number: H2QQV0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 25, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported