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Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD3Imported
ORF Names:CK820_G0007600Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:8178 SOD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501457599919 – 240Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST222

Expressioni

Gene expression databases

BgeeiENSPTRG00000015956

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000027474

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 210Sod_CuInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
KOiK16627
OMAiEQEDDMG
OrthoDBiEOG091G13ID
TreeFamiTF105133

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

H2QPA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM
60 70 80 90 100
QRRDDDGALH AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE
110 120 130 140 150
GFPTEPNSSS RAIHVHQFGD LSQGCESTGP HYNPLAVPHP QHPGDFGNFA
160 170 180 190 200
VRDGSLWRYR AGLAASLAGP HSIVGRAVVV HAGEDDLGRG GNQASVENGN
210 220 230 240
AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA
Length:240
Mass (Da):25,851
Last modified:March 21, 2012 - v1
Checksum:i585B8DEBFC506CF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04033720 Genomic DNA No translation available.
GABC01003964 mRNA Translation: JAA07374.1
GABF01005884 mRNA Translation: JAA16261.1
GABD01000158 mRNA Translation: JAA32942.1
GABE01008398 mRNA Translation: JAA36341.1
GABE01008397 mRNA Translation: JAA36342.1
NBAG03000222 Genomic DNA Translation: PNI75961.1
RefSeqiXP_009445714.1, XM_009447439.1

Genome annotation databases

EnsembliENSPTRT00000029775; ENSPTRP00000027474; ENSPTRG00000015956
GeneIDi461143
KEGGiptr:461143

Similar proteinsi

Entry informationi

Entry nameiH2QPA4_PANTR
AccessioniPrimary (citable) accession number: H2QPA4
Secondary accession number(s): A0A2J8NW28
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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