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H2QPA4

- H2QPA4_PANTR

UniProt

H2QPA4 - H2QPA4_PANTR

Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    Cofactori

    Binds 1 copper ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. superoxide dismutase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. response to hypoxia Source: Ensembl

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Name:SOD3Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: Ensembl
    3. trans-Golgi network Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliH2QPA4.
    SMRiH2QPA4. Positions 55-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00530000063226.
    KOiK16627.
    OMAiHPRHPGD.
    OrthoDBiEOG77HDHG.
    TreeFamiTF105133.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2QPA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM    50
    QRRDDDGALH AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE 100
    GFPTEPNSSS RAIHVHQFGD LSQGCESTGP HYNPLAVPHP QHPGDFGNFA 150
    VRDGSLWRYR AGLAASLAGP HSIVGRAVVV HAGEDDLGRG GNQASVENGN 200
    AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA 240
    Length:240
    Mass (Da):25,851
    Last modified:March 21, 2012 - v1
    Checksum:i585B8DEBFC506CF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03031637 Genomic DNA. No translation available.
    GABC01003964 mRNA. Translation: JAA07374.1.
    GABF01005884 mRNA. Translation: JAA16261.1.
    GABD01000158 mRNA. Translation: JAA32942.1.
    GABE01008398 mRNA. Translation: JAA36341.1.
    GABE01008397 mRNA. Translation: JAA36342.1.
    RefSeqiXP_001164716.1. XM_001164716.3.

    Genome annotation databases

    EnsembliENSPTRT00000029775; ENSPTRP00000027474; ENSPTRG00000015956.
    GeneIDi461143.
    KEGGiptr:461143.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03031637 Genomic DNA. No translation available.
    GABC01003964 mRNA. Translation: JAA07374.1 .
    GABF01005884 mRNA. Translation: JAA16261.1 .
    GABD01000158 mRNA. Translation: JAA32942.1 .
    GABE01008398 mRNA. Translation: JAA36341.1 .
    GABE01008397 mRNA. Translation: JAA36342.1 .
    RefSeqi XP_001164716.1. XM_001164716.3.

    3D structure databases

    ProteinModelPortali H2QPA4.
    SMRi H2QPA4. Positions 55-223.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000029775 ; ENSPTRP00000027474 ; ENSPTRG00000015956 .
    GeneIDi 461143.
    KEGGi ptr:461143.

    Organism-specific databases

    CTDi 6649.

    Phylogenomic databases

    GeneTreei ENSGT00530000063226.
    KOi K16627.
    OMAi HPRHPGD.
    OrthoDBi EOG77HDHG.
    TreeFami TF105133.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR024141. SOD_Cu/Zn_extracel.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

    Entry informationi

    Entry nameiH2QPA4_PANTR
    AccessioniPrimary (citable) accession number: H2QPA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3