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H2QPA4

- H2QPA4_PANTR

UniProt

H2QPA4 - H2QPA4_PANTR

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Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Binds 1 copper ion per subunit.UniRule annotation
Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. superoxide dismutase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. response to hypoxia Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD3Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. trans-Golgi network Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliH2QPA4.
SMRiH2QPA4. Positions 55-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063226.
InParanoidiH2QPA4.
KOiK16627.
OMAiHPRHPGD.
OrthoDBiEOG77HDHG.
TreeFamiTF105133.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003:SF36. PTHR10003:SF36. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2QPA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM
60 70 80 90 100
QRRDDDGALH AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE
110 120 130 140 150
GFPTEPNSSS RAIHVHQFGD LSQGCESTGP HYNPLAVPHP QHPGDFGNFA
160 170 180 190 200
VRDGSLWRYR AGLAASLAGP HSIVGRAVVV HAGEDDLGRG GNQASVENGN
210 220 230 240
AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA
Length:240
Mass (Da):25,851
Last modified:March 21, 2012 - v1
Checksum:i585B8DEBFC506CF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03031637 Genomic DNA. No translation available.
GABC01003964 mRNA. Translation: JAA07374.1.
GABF01005884 mRNA. Translation: JAA16261.1.
GABD01000158 mRNA. Translation: JAA32942.1.
GABE01008398 mRNA. Translation: JAA36341.1.
GABE01008397 mRNA. Translation: JAA36342.1.
RefSeqiXP_001164716.1. XM_001164716.3.

Genome annotation databases

EnsembliENSPTRT00000029775; ENSPTRP00000027474; ENSPTRG00000015956.
GeneIDi461143.
KEGGiptr:461143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03031637 Genomic DNA. No translation available.
GABC01003964 mRNA. Translation: JAA07374.1 .
GABF01005884 mRNA. Translation: JAA16261.1 .
GABD01000158 mRNA. Translation: JAA32942.1 .
GABE01008398 mRNA. Translation: JAA36341.1 .
GABE01008397 mRNA. Translation: JAA36342.1 .
RefSeqi XP_001164716.1. XM_001164716.3.

3D structure databases

ProteinModelPortali H2QPA4.
SMRi H2QPA4. Positions 55-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000029775 ; ENSPTRP00000027474 ; ENSPTRG00000015956 .
GeneIDi 461143.
KEGGi ptr:461143.

Organism-specific databases

CTDi 6649.

Phylogenomic databases

GeneTreei ENSGT00530000063226.
InParanoidi H2QPA4.
KOi K16627.
OMAi HPRHPGD.
OrthoDBi EOG77HDHG.
TreeFami TF105133.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR024141. SOD_Cu/Zn_extracel.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
PANTHERi PTHR10003:SF36. PTHR10003:SF36. 1 hit.
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

Entry informationi

Entry nameiH2QPA4_PANTR
AccessioniPrimary (citable) accession number: H2QPA4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3