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H2QJQ3

- H2QJQ3_PANTR

UniProt

H2QJQ3 - H2QJQ3_PANTR

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Protein
Submitted name:

Histone deacetylase 4

Gene
HDAC4
Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. potassium ion binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. transcription corepressor activity Source: Ensembl
  5. transcription regulatory region DNA binding Source: Ensembl
  6. zinc ion binding Source: Ensembl

GO - Biological processi

  1. chromatin remodeling Source: Ensembl
  2. histone H3 deacetylation Source: Ensembl
  3. histone H4 deacetylation Source: Ensembl
  4. negative regulation of cell proliferation Source: Ensembl
  5. negative regulation of glycolytic process Source: Ensembl
  6. negative regulation of myotube differentiation Source: Ensembl
  7. negative regulation of osteoblast differentiation Source: Ensembl
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. peptidyl-lysine deacetylation Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of protein sumoylation Source: Ensembl
  14. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. regulation of cardiac muscle contraction by calcium ion signaling Source: Ensembl
  17. regulation of protein binding Source: Ensembl
  18. regulation of skeletal muscle fiber development Source: Ensembl
  19. response to denervation involved in regulation of muscle adaptation Source: Ensembl
  20. response to interleukin-1 Source: Ensembl
  21. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HDAC4Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. actomyosin Source: Ensembl
  2. cytosol Source: Ensembl
  3. histone deacetylase complex Source: Ensembl
  4. neuromuscular junction Source: Ensembl
  5. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliH2QJQ3.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
KOiK11406.
OMAiVSFGGHR.
OrthoDBiEOG7RFTH5.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

H2QJQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVAAALPL QVAPSAVPMD     50
LRLDHQFSLP VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL 100
SRQHEAQLHE HIKQQQEMLA MKHQQELLEH QRKLERHRQE QELEKQHREQ 150
KLQQLKNKEK GKESAVASTE VKMKLQEFVL NKKKALAHRN LNHCISSDPR 200
YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP LRKTASEPNL 250
KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP 300
SSPNNSSGSV SAENGIAPTV PSIPAETSLA HRLVAREGSA APLPLYTSPS 350
LPNITLGLPA TGPSAGTAGQ QDAERLALPA LQQRLSLFPG THLTPYLSTS 400
PLERDGGAAH SPLLQHMVLL EQPPAQAPLV TGLGALPLHA QSLVGADRVS 450
PSIHKLRQHR PLGRTQSAPL PQNAQALQHL VIQQQHQQFL EKHKQQFQQQ 500
QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY LDRLPGQKEA 550
HAQAGVQVKQ EPIESDDEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ 600
RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP 650
RFTTGLVYDT LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC 700
IRGRKATLEE LQTVHSEAHT LLYGTNPLNR QKLDSKKLLG SLASVFVRLP 750
CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE LVFKVATGEL KNGFAVVRPP 800
GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD VHHGNGTQQA 850
FYSDPSVLYV SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP 900
PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA 950
RCFGYLTKQL MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL 1000
PEKVLQQRPN ANAVRSMEKV MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN 1050
EEAETVTAMA SLSVGVKPAE KRPDEEPMEE EPPL 1084
Length:1,084
Mass (Da):118,964
Last modified:March 21, 2012 - v1
Checksum:i098128158A8822EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
AACZ03021142 Genomic DNA. No translation available.
AACZ03021143 Genomic DNA. No translation available.
AACZ03021144 Genomic DNA. No translation available.
AACZ03021145 Genomic DNA. No translation available.
AACZ03021146 Genomic DNA. No translation available.
AACZ03021147 Genomic DNA. No translation available.
AACZ03021148 Genomic DNA. No translation available.
AACZ03021149 Genomic DNA. No translation available.
AACZ03021150 Genomic DNA. No translation available.
AACZ03021151 Genomic DNA. No translation available.
AACZ03021152 Genomic DNA. No translation available.
AACZ03021153 Genomic DNA. No translation available.
AACZ03021154 Genomic DNA. No translation available.
AACZ03021155 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1.
GABF01006303 mRNA. Translation: JAA15842.1.
GABD01008396 mRNA. Translation: JAA24704.1.
GABE01001485 mRNA. Translation: JAA43254.1.
RefSeqiXP_003309602.1. XM_003309554.1.

Genome annotation databases

EnsembliENSPTRT00000024291; ENSPTRP00000022412; ENSPTRG00000013097.
GeneIDi460060.
KEGGiptr:460060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
AACZ03021142 Genomic DNA. No translation available.
AACZ03021143 Genomic DNA. No translation available.
AACZ03021144 Genomic DNA. No translation available.
AACZ03021145 Genomic DNA. No translation available.
AACZ03021146 Genomic DNA. No translation available.
AACZ03021147 Genomic DNA. No translation available.
AACZ03021148 Genomic DNA. No translation available.
AACZ03021149 Genomic DNA. No translation available.
AACZ03021150 Genomic DNA. No translation available.
AACZ03021151 Genomic DNA. No translation available.
AACZ03021152 Genomic DNA. No translation available.
AACZ03021153 Genomic DNA. No translation available.
AACZ03021154 Genomic DNA. No translation available.
AACZ03021155 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1 .
GABF01006303 mRNA. Translation: JAA15842.1 .
GABD01008396 mRNA. Translation: JAA24704.1 .
GABE01001485 mRNA. Translation: JAA43254.1 .
RefSeqi XP_003309602.1. XM_003309554.1.

3D structure databases

ProteinModelPortali H2QJQ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000024291 ; ENSPTRP00000022412 ; ENSPTRG00000013097 .
GeneIDi 460060.
KEGGi ptr:460060.

Organism-specific databases

CTDi 9759.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
KOi K11406.
OMAi VSFGGHR.
OrthoDBi EOG7RFTH5.
TreeFami TF106174.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the chimpanzee Y chromosome."
    Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S., Wilson R.K., Page D.C.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

Entry informationi

Entry nameiH2QJQ3_PANTR
AccessioniPrimary (citable) accession number: H2QJQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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