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H2QJQ3

- H2QJQ3_PANTR

UniProt

H2QJQ3 - H2QJQ3_PANTR

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Protein
Submitted name:

Histone deacetylase 4

Gene

HDAC4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi667 – 6671ZincUniRule annotation
Metal bindingi669 – 6691ZincUniRule annotation
Metal bindingi675 – 6751ZincUniRule annotation
Metal bindingi751 – 7511ZincUniRule annotation
Active sitei803 – 8031UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: InterPro
  2. potassium ion binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. transcription corepressor activity Source: Ensembl
  5. transcription regulatory region DNA binding Source: Ensembl
  6. zinc ion binding Source: Ensembl

GO - Biological processi

  1. chromatin remodeling Source: Ensembl
  2. histone H3 deacetylation Source: Ensembl
  3. histone H4 deacetylation Source: Ensembl
  4. negative regulation of cell proliferation Source: Ensembl
  5. negative regulation of glycolytic process Source: Ensembl
  6. negative regulation of myotube differentiation Source: Ensembl
  7. negative regulation of osteoblast differentiation Source: Ensembl
  8. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. osteoblast development Source: Ensembl
  11. peptidyl-lysine deacetylation Source: Ensembl
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of protein sumoylation Source: Ensembl
  14. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. regulation of cardiac muscle contraction by calcium ion signaling Source: Ensembl
  17. regulation of protein binding Source: Ensembl
  18. regulation of skeletal muscle fiber development Source: Ensembl
  19. response to denervation involved in regulation of muscle adaptation Source: Ensembl
  20. response to interleukin-1 Source: Ensembl
  21. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HDAC4Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. actomyosin Source: Ensembl
  2. cytosol Source: Ensembl
  3. histone deacetylase complex Source: Ensembl
  4. neuromuscular junction Source: Ensembl
  5. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliH2QJQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
InParanoidiH2QJQ3.
KOiK11406.
OMAiVSFGGHR.
OrthoDBiEOG7RFTH5.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

H2QJQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVAAALPL QVAPSAVPMD
60 70 80 90 100
LRLDHQFSLP VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL
110 120 130 140 150
SRQHEAQLHE HIKQQQEMLA MKHQQELLEH QRKLERHRQE QELEKQHREQ
160 170 180 190 200
KLQQLKNKEK GKESAVASTE VKMKLQEFVL NKKKALAHRN LNHCISSDPR
210 220 230 240 250
YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP LRKTASEPNL
260 270 280 290 300
KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP
310 320 330 340 350
SSPNNSSGSV SAENGIAPTV PSIPAETSLA HRLVAREGSA APLPLYTSPS
360 370 380 390 400
LPNITLGLPA TGPSAGTAGQ QDAERLALPA LQQRLSLFPG THLTPYLSTS
410 420 430 440 450
PLERDGGAAH SPLLQHMVLL EQPPAQAPLV TGLGALPLHA QSLVGADRVS
460 470 480 490 500
PSIHKLRQHR PLGRTQSAPL PQNAQALQHL VIQQQHQQFL EKHKQQFQQQ
510 520 530 540 550
QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY LDRLPGQKEA
560 570 580 590 600
HAQAGVQVKQ EPIESDDEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ
610 620 630 640 650
RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP
660 670 680 690 700
RFTTGLVYDT LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC
710 720 730 740 750
IRGRKATLEE LQTVHSEAHT LLYGTNPLNR QKLDSKKLLG SLASVFVRLP
760 770 780 790 800
CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE LVFKVATGEL KNGFAVVRPP
810 820 830 840 850
GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD VHHGNGTQQA
860 870 880 890 900
FYSDPSVLYV SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP
910 920 930 940 950
PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA
960 970 980 990 1000
RCFGYLTKQL MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL
1010 1020 1030 1040 1050
PEKVLQQRPN ANAVRSMEKV MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN
1060 1070 1080
EEAETVTAMA SLSVGVKPAE KRPDEEPMEE EPPL
Length:1,084
Mass (Da):118,964
Last modified:March 21, 2012 - v1
Checksum:i098128158A8822EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
AACZ03021142 Genomic DNA. No translation available.
AACZ03021143 Genomic DNA. No translation available.
AACZ03021144 Genomic DNA. No translation available.
AACZ03021145 Genomic DNA. No translation available.
AACZ03021146 Genomic DNA. No translation available.
AACZ03021147 Genomic DNA. No translation available.
AACZ03021148 Genomic DNA. No translation available.
AACZ03021149 Genomic DNA. No translation available.
AACZ03021150 Genomic DNA. No translation available.
AACZ03021151 Genomic DNA. No translation available.
AACZ03021152 Genomic DNA. No translation available.
AACZ03021153 Genomic DNA. No translation available.
AACZ03021154 Genomic DNA. No translation available.
AACZ03021155 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1.
GABF01006303 mRNA. Translation: JAA15842.1.
GABD01008396 mRNA. Translation: JAA24704.1.
GABE01001485 mRNA. Translation: JAA43254.1.
RefSeqiXP_003309602.1. XM_003309554.1.

Genome annotation databases

EnsembliENSPTRT00000024291; ENSPTRP00000022412; ENSPTRG00000013097.
GeneIDi460060.
KEGGiptr:460060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
AACZ03021142 Genomic DNA. No translation available.
AACZ03021143 Genomic DNA. No translation available.
AACZ03021144 Genomic DNA. No translation available.
AACZ03021145 Genomic DNA. No translation available.
AACZ03021146 Genomic DNA. No translation available.
AACZ03021147 Genomic DNA. No translation available.
AACZ03021148 Genomic DNA. No translation available.
AACZ03021149 Genomic DNA. No translation available.
AACZ03021150 Genomic DNA. No translation available.
AACZ03021151 Genomic DNA. No translation available.
AACZ03021152 Genomic DNA. No translation available.
AACZ03021153 Genomic DNA. No translation available.
AACZ03021154 Genomic DNA. No translation available.
AACZ03021155 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1 .
GABF01006303 mRNA. Translation: JAA15842.1 .
GABD01008396 mRNA. Translation: JAA24704.1 .
GABE01001485 mRNA. Translation: JAA43254.1 .
RefSeqi XP_003309602.1. XM_003309554.1.

3D structure databases

ProteinModelPortali H2QJQ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000024291 ; ENSPTRP00000022412 ; ENSPTRG00000013097 .
GeneIDi 460060.
KEGGi ptr:460060.

Organism-specific databases

CTDi 9759.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
InParanoidi H2QJQ3.
KOi K11406.
OMAi VSFGGHR.
OrthoDBi EOG7RFTH5.
TreeFami TF106174.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR019154. Arb2_domain.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF09757. Arb2. 1 hit.
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the chimpanzee Y chromosome."
    Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S., Wilson R.K., Page D.C.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported, SkinImported and Smooth vascularImported.

Entry informationi

Entry nameiH2QJQ3_PANTR
AccessioniPrimary (citable) accession number: H2QJQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3