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Protein

Histone deacetylase

Gene

HDAC4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi555ZincUniRule annotation1
Metal bindingi557ZincUniRule annotation1
Metal bindingi563ZincUniRule annotation1
Metal bindingi639ZincUniRule annotation1
Active sitei691UniRule annotation1
Sitei864Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:HDAC4Imported
ORF Names:CK820_G0045442Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 2B

Organism-specific databases

VGNCiVGNC:1957. HDAC4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000013097.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 35HDAC4_GlnInterPro annotationAdd BLAST35
Domaini563 – 880Hist_deacetylInterPro annotationAdd BLAST318

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3 – 41Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
OMAiKCECIRG.
OrthoDBiEOG091G0EQO.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR033660. HDAC4.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PTHR10625:SF100. PTHR10625:SF100. 1 hit.
PfamiView protein in Pfam
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

H2QJQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAMKHQQEL LEHQRKLERH RQEQELEKQH REQKLQQLKN KEKGKESAVA
60 70 80 90 100
STEVKMKLQE FVLNKKKALA HRNLNHCISS DPRYWYGKTQ HSSLDQSSPP
110 120 130 140 150
QSGVSTSYNH PVLGMYDAKD DFPLRKTASE PNLKLRSRLK QKVAERRSSP
160 170 180 190 200
LLRRKDGPVV TALKKRPLDV TDSACSSAPG SGPSSPNNSS GSVSAENGIA
210 220 230 240 250
PTVPSIPAET SLAHRLVARE GSAAPLPLYT SPSLPNITLG LPATGPSAGT
260 270 280 290 300
AGQQDAERLA LPALQQRLSL FPGTHLTPYL STSPLERDGG AAHSPLLQHM
310 320 330 340 350
VLLEQPPAQA PLVTDWYLSG LGALPLHAQS LVGADRVSPS IHKLRQHRPL
360 370 380 390 400
GRTQSAPLPQ NAQALQHLVI QQQHQQFLEK HKQQFQQQQL QMNKIIPKPS
410 420 430 440 450
EPARQPESHP EETEEELREH QALLDEPYLD RLPGQKEAHA QAGVQVKQEP
460 470 480 490 500
IESDDEEAEP PREVEPGQRQ PSEQELLFRQ QALLLEQQRI HQLRNYQASM
510 520 530 540 550
EAAGIPVSFG GHRPLSRAQS SPASATFPVS VQEPPTKPRF TTGLVYDTLM
560 570 580 590 600
LKHQCTCGSS SSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ
610 620 630 640 650
TVHSEAHTLL YGTNPLNRQK LDSKKLLGSL ASVFVRLPCG GVGVDSDTIW
660 670 680 690 700
NEVHSAGAAR LAVGCVVELV FKVATGELKN GFAVVRPPGH HAEESTPMGF
710 720 730 740 750
CYFNSVAVAA KLLQQRLSVS KILIVDWDVH HGNGTQQAFY SDPSVLYVSL
760 770 780 790 800
HRYDDGNFFP GSGAPDEVGT GPGVGFNVNM AFTGGLDPPM GDAEYLAAFR
810 820 830 840 850
TVVMPIASEF APDVVLVSSG FDAVEGHPTP LGGYNLSARC FGYLTKQLMG
860 870 880 890 900
LAGGRIVLAL EGGHDLTAIC DASEACVSAL LGNELDPLPE KVLQQRPNAN
910 920 930 940 950
AVRSMEKVME IHSKYWRCLQ RTTSTAGRSL IEAQTCENEE AETVTAMASL
960 970
SVGVKPAEKR PDEEPMEEEP PL
Length:972
Mass (Da):106,321
Last modified:February 28, 2018 - v2
Checksum:iD34123219FCFA688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04070577 Genomic DNA. No translation available.
AC194550 Genomic DNA. No translation available.
NBAG03000434 Genomic DNA. Translation: PNI24788.1.

Genome annotation databases

EnsembliENSPTRT00000024291; ENSPTRP00000022412; ENSPTRG00000013097.

Similar proteinsi

Entry informationi

Entry nameiH2QJQ3_PANTR
AccessioniPrimary (citable) accession number: H2QJQ3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported