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Protein

Histone deacetylase

Gene

HDAC4

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi667ZincUniRule annotation1
Metal bindingi669ZincUniRule annotation1
Metal bindingi675ZincUniRule annotation1
Metal bindingi751ZincUniRule annotation1
Active sitei803UniRule annotation1
Sitei976Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:HDAC4Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 2B

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSPTRG00000013097.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022412.

Structurei

3D structure databases

ProteinModelPortaliH2QJQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 152HDAC4_GlnInterPro annotationAdd BLAST90
Domaini675 – 992Hist_deacetylInterPro annotationAdd BLAST318

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili113 – 158Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
OMAiKCESIRG.
OrthoDBiEOG091G0EQO.
TreeFamiTF106174.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR033660. HDAC4.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PTHR10625:SF100. PTHR10625:SF100. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

H2QJQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVAAALPL QVAPSAVPMD
60 70 80 90 100
LRLDHQFSLP VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL
110 120 130 140 150
SRQHEAQLHE HIKQQQEMLA MKHQQELLEH QRKLERHRQE QELEKQHREQ
160 170 180 190 200
KLQQLKNKEK GKESAVASTE VKMKLQEFVL NKKKALAHRN LNHCISSDPR
210 220 230 240 250
YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP LRKTASEPNL
260 270 280 290 300
KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP
310 320 330 340 350
SSPNNSSGSV SAENGIAPTV PSIPAETSLA HRLVAREGSA APLPLYTSPS
360 370 380 390 400
LPNITLGLPA TGPSAGTAGQ QDAERLALPA LQQRLSLFPG THLTPYLSTS
410 420 430 440 450
PLERDGGAAH SPLLQHMVLL EQPPAQAPLV TGLGALPLHA QSLVGADRVS
460 470 480 490 500
PSIHKLRQHR PLGRTQSAPL PQNAQALQHL VIQQQHQQFL EKHKQQFQQQ
510 520 530 540 550
QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY LDRLPGQKEA
560 570 580 590 600
HAQAGVQVKQ EPIESDDEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ
610 620 630 640 650
RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP
660 670 680 690 700
RFTTGLVYDT LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC
710 720 730 740 750
IRGRKATLEE LQTVHSEAHT LLYGTNPLNR QKLDSKKLLG SLASVFVRLP
760 770 780 790 800
CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE LVFKVATGEL KNGFAVVRPP
810 820 830 840 850
GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD VHHGNGTQQA
860 870 880 890 900
FYSDPSVLYV SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP
910 920 930 940 950
PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA
960 970 980 990 1000
RCFGYLTKQL MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL
1010 1020 1030 1040 1050
PEKVLQQRPN ANAVRSMEKV MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN
1060 1070 1080
EEAETVTAMA SLSVGVKPAE KRPDEEPMEE EPPL
Length:1,084
Mass (Da):118,964
Last modified:March 21, 2012 - v1
Checksum:i098128158A8822EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1.
GABF01006303 mRNA. Translation: JAA15842.1.
GABD01008396 mRNA. Translation: JAA24704.1.
GABE01001485 mRNA. Translation: JAA43254.1.
RefSeqiXP_016806339.1. XM_016950850.1.

Genome annotation databases

EnsembliENSPTRT00000024291; ENSPTRP00000022412; ENSPTRG00000013097.
GeneIDi460060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03021132 Genomic DNA. No translation available.
AACZ03021133 Genomic DNA. No translation available.
AACZ03021134 Genomic DNA. No translation available.
AACZ03021135 Genomic DNA. No translation available.
AACZ03021136 Genomic DNA. No translation available.
AACZ03021137 Genomic DNA. No translation available.
AACZ03021138 Genomic DNA. No translation available.
AACZ03021139 Genomic DNA. No translation available.
AACZ03021140 Genomic DNA. No translation available.
AACZ03021141 Genomic DNA. No translation available.
GABC01008758 mRNA. Translation: JAA02580.1.
GABF01006303 mRNA. Translation: JAA15842.1.
GABD01008396 mRNA. Translation: JAA24704.1.
GABE01001485 mRNA. Translation: JAA43254.1.
RefSeqiXP_016806339.1. XM_016950850.1.

3D structure databases

ProteinModelPortaliH2QJQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000024291; ENSPTRP00000022412; ENSPTRG00000013097.
GeneIDi460060.

Organism-specific databases

CTDi9759.

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
OMAiKCESIRG.
OrthoDBiEOG091G0EQO.
TreeFamiTF106174.

Gene expression databases

BgeeiENSPTRG00000013097.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR033660. HDAC4.
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PTHR10625:SF100. PTHR10625:SF100. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Entry informationi

Entry nameiH2QJQ3_PANTR
AccessioniPrimary (citable) accession number: H2QJQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 2, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.