Isocitrate dehydrogenase [NADP] - Pan troglodytes (Chimpanzee)

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H2QJB5 (H2QJB5_PANTR) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 9. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108

Gene names

Name:	ENSG00000138413 Ensembl ENSPTRP00000021992
Synonyms:	IDH1 EMBL JAA01131.1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000021992

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Isocitrate + NADP⁺ = 2-oxoglutarate + CO₂ + NADPH. PIRNR PIRNR000108
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle PIRNR PIRNR000108
Ligand	Magnesium PIRNR PIRNR000108 PIRSR PIRSR000108-3 Manganese PIRNR PIRNR000108 PIRSR PIRSR000108-3 Metal-binding PIRNR PIRNR000108 PIRSR PIRSR000108-3 NADP PIRNR PIRNR000108 PIRSR PIRSR000108-4
Molecular function	Oxidoreductase RuleBase RU004444 PIRNR PIRNR000108
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	isocitrate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

75 – 77

NADP By similarity PIRSR PIRSR000108-4

Nucleotide binding

310 – 315

NADP By similarity PIRSR PIRSR000108-4

Region

94 – 100

Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding

252

Magnesium or manganese By similarity PIRSR PIRSR000108-3

Metal binding

275

Magnesium or manganese By similarity PIRSR PIRSR000108-3

Binding site

Substrate By similarity PIRSR PIRSR000108-2

Binding site

NADP By similarity PIRSR PIRSR000108-4

Binding site

109

Substrate By similarity PIRSR PIRSR000108-2

Binding site

132

Substrate By similarity PIRSR PIRSR000108-2

Binding site

260

NADP By similarity PIRSR PIRSR000108-4

Binding site

328

NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4

Site

139

Critical for catalysis By similarity PIRSR PIRSR000108-1

Site

212

Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence

Length

Mass (Da)

Tools

H2QJB5 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 9CACBFD9C5029C3E
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FASTA

414

46,713

        10         20         30         40         50         60 
MSKKISGGSV VEMQGDEMTR IIWELIKEKL IFPYVELDLH SYDLGIENRD ATNDQVTKDA 

        70         80         90        100        110        120 
AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL 

       130        140        150        160        170        180 
VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GTQKVTYLVH NFEEGGGVAM 

       190        200        210        220        230        240 
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKRYKSQFE 

       250        260        270        280        290        300 
AQKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLVCPDG 

       310        320        330        340        350        360 
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNK ELAFFANALE 

       370        380        390        400        410 
EVSIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKIKLA QAKL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the chimpanzee Y chromosome." Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S., Wilson R.K., Page D.C. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
[4]	"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences." Maudhoo M.D., Meehan D.T., Norgren R.B.Jr. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose stromal EMBL JAA01131.1, Skeletal muscle EMBL JAA34314.1, Skin EMBL JAA28927.1 and Smooth vascular EMBL JAA15135.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACZ03019851 Genomic DNA. No translation available. AACZ03019852 Genomic DNA. No translation available. AACZ03019853 Genomic DNA. No translation available. GABC01010207 mRNA. Translation: JAA01131.1. GABF01007010 mRNA. Translation: JAA15135.1. GABD01004173 mRNA. Translation: JAA28927.1. GABE01010425 mRNA. Translation: JAA34314.1.
RefSeq	XP_001141655.1. XM_001141655.2. XP_001141734.1. XM_001141734.2. XP_001141810.1. XM_001141810.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000023853; ENSPTRP00000021992; ENSPTRG00000012865.
GeneID	460113.
KEGG	ptr:460113.
Organism-specific databases
CTD	3417.
Phylogenomic databases
GeneTree	ENSGT00390000012547.
KO	K00031.
OMA	ALGMFNT.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR004790. Isocitrate_DH_NADP. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11822. PTHR11822. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMs	TIGR00127. nadp_idh_euk. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2QJB5_PANTR

Accession

Primary (citable) accession number: H2QJB5

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	March 6, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information