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Protein
Submitted name:

KCNJ2 isoform 1

Gene

KCNJ2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei172Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
KCNJ2 isoform 1Imported
Submitted name:
KCNJ2 isoform 2Imported
Submitted name:
Potassium inwardly-rectifying channel, subfamily J, member 2Imported
Submitted name:
Potassium voltage-gated channel subfamily J member 2Imported
Gene namesi
Name:KCNJ2Imported
ORF Names:CK820_G0038079Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:12318 KCNJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 107HelicalSequence analysisAdd BLAST25
Transmembranei156 – 181HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSPTRG00000009590

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000016291

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 47IRK_NInterPro annotationAdd BLAST47

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
KOiK04996
OMAiVFSHNAT
OrthoDBiEOG091G08HC
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003271 K_chnl_inward-rec_Kir2.1
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR013673 K_chnl_inward-rec_Kir_N
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF43 PTHR11767:SF43, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PF08466 IRK_N, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01324 KIR21CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

H2QDR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK
60 70 80 90 100
DGHCNVQFIN VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG
110 120 130 140 150
CVFWLIALLH GDLDASKEGK ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV
160 170 180 190 200
TDECPIAVFM VVFQSIVGCI IDAFIIGAVM AKMAKPKKRN ETLVFSHNAV
210 220 230 240 250
IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG EYIPLDQIDI
260 270 280 290 300
NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG
310 320 330 340 350
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV
360 370 380 390 400
PNTPLCSARD LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST
410 420
DTPPDIDLHN QASVPLEPRP LRRESEI
Length:427
Mass (Da):48,288
Last modified:March 21, 2012 - v1
Checksum:iAB37CAD4B99B4050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04070098 Genomic DNA No translation available.
GABD01002834 mRNA Translation: JAA30266.1
NBAG03000357 Genomic DNA Translation: PNI35646.1
NBAG03000357 Genomic DNA Translation: PNI35647.1
RefSeqiXP_523701.2, XM_523701.6

Genome annotation databases

EnsembliENSPTRT00000017585; ENSPTRP00000016291; ENSPTRG00000009590
GeneIDi468312
KEGGiptr:468312

Similar proteinsi

Entry informationi

Entry nameiH2QDR5_PANTR
AccessioniPrimary (citable) accession number: H2QDR5
Secondary accession number(s): A0A2J8KKW9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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