H2QCP0 (H2QCP0_PANTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

Name:	ENSG00000005156 Ensembl ENSPTRP00000015364
Synonyms:	LIG3 EMBL JAA03707.1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome] Ensembl ENSPTRP00000015364

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	1009 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL JAA03707.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2QCP0 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: D4CFDD894FAA4E82	FASTA	1,009	112,950
	10 20 30 40 50 60 MSLAFKILFP QTLRALSRKE LCLFRKRHWR DVRQFSQWSE TDLLHGHPLF LRRKPILSFQ 70 80 90 100 110 120 GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG 130 140 150 160 170 180 KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH 190 200 210 220 230 240 IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP 250 260 270 280 290 300 SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH 310 320 330 340 350 360 GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ 370 380 390 400 410 420 SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL 430 440 450 460 470 480 KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP 490 500 510 520 530 540 VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH 550 560 570 580 590 600 FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF 610 620 630 640 650 660 NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK 670 680 690 700 710 720 DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS 730 740 750 760 770 780 QKWCTVTKCA GGHDDATLAR LQKELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA 790 800 810 820 830 840 VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV 850 860 870 880 890 900 VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS 910 920 930 940 950 960 TMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP DFSRLRRYFV 970 980 990 1000 AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI RKRRLVAPC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Initial sequence of the chimpanzee genome and comparison with the human genome." Chimpanzee sequencing and analysis consortium Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
[3]	"De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences." Maudhoo M.D., Meehan D.T., Norgren R.B.Jr. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Adipose stromal EMBL JAA03707.1 and Skin EMBL JAA32052.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACZ03109009 Genomic DNA. No translation available. AACZ03109010 Genomic DNA. No translation available. GABC01007631 mRNA. Translation: JAA03707.1. GABD01001048 mRNA. Translation: JAA32052.1.
RefSeq	XP_511409.3. XM_511409.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000016599; ENSPTRP00000015364; ENSPTRG00000009008.
GeneID	454581.
KEGG	ptr:454581.
Organism-specific databases
CTD	3980.
Phylogenomic databases
GeneTree	ENSGT00700000104500.
KO	K10776.
OMA	WSETDLL.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit. 3.30.1740.10. 1 hit.
InterPro	IPR001357. BRCT_dom. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. IPR001510. Znf_PARP. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. PF00645. zf-PARP. 1 hit. [Graphical view]
SMART	SM00292. BRCT. 1 hit. [Graphical view]
SUPFAM	SSF52113. BRCT. 1 hit. SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS50172. BRCT. 1 hit. PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. PS00347. PARP_ZN_FINGER_1. 1 hit. PS50064. PARP_ZN_FINGER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2QCP0_PANTR

Accession

Primary (citable) accession number: H2QCP0

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	March 6, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)