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Protein
Submitted name:

DUOX2 isoform 1

Gene

DUOX2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi832 – 843PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi868 – 879PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DUOX2 isoform 1Imported
Submitted name:
Dual oxidase 2Imported
Gene namesi
Name:DUOX2Imported
ORF Names:CK820_G0008713Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:2483 DUOX2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei598 – 622HelicalSequence analysisAdd BLAST25
Transmembranei1038 – 1057HelicalSequence analysisAdd BLAST20
Transmembranei1077 – 1099HelicalSequence analysisAdd BLAST23
Transmembranei1149 – 1168HelicalSequence analysisAdd BLAST20
Transmembranei1180 – 1205HelicalSequence analysisAdd BLAST26
Transmembranei1217 – 1234HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501509255526 – 1548Sequence analysisAdd BLAST1523

Proteomic databases

PaxDbiH2Q9C5

Expressioni

Gene expression databases

BgeeiENSPTRG00000007026

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000012012

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini819 – 854EF-handInterPro annotationAdd BLAST36
Domaini855 – 890EF-handInterPro annotationAdd BLAST36
Domaini899 – 934EF-handInterPro annotationAdd BLAST36
Domaini1267 – 1373FAD-binding FR-typeInterPro annotationAdd BLAST107

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
InParanoidiH2Q9C5
KOiK13411
OMAiNASCHFR
OrthoDBiEOG091G00PO
TreeFamiTF105424

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR034818 DUOX2
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 Fd_Rdtase_FAD-bd
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67 PTHR11972:SF67, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 1 hit
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q9C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRARPEALM LLGALLTGSL DPSGSQDALS LPWEVQRYDG WFNNLRHHER
60 70 80 90 100
GAVGCRLQRR VPANYADGVY QALEEPQLPN PRRLSNAATR GIAGLPSLHN
110 120 130 140 150
RTVLGVFFGY HVLSDVVSVE TPGCPAEFLN IRIPPGDPVF DPDQRGDVVL
160 170 180 190 200
PFQRSRWDPE TGRSPSNPRD LANQVTGWLD GSAIYGSSHS WSDALRSFSG
210 220 230 240 250
GQLASGPDPA FPRDSQNPLL MWAAPDPATG QNGPRGLYAF GAERGNREPF
260 270 280 290 300
LQALGLLWFR YHNLWAQRLA RQHPDWEDEE LFQHARKRVI ATYQNIAVYE
310 320 330 340 350
WLPSFLQKTL PEYTGYRPFL DPSISPEFVV ASEQFFSTMV PPGVYMRNAS
360 370 380 390 400
CHFRKVLNKG FQSSQALRVC NNYWIRENPN LNSTQEVNEL LLGMASQISE
410 420 430 440 450
LEDNIVVEDL RDYWPGPGKF SRTDYVASSI QRGRDMGLPS YSQALLAFGL
460 470 480 490 500
DIPRNWSDLN PNVDPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF
510 520 530 540 550
SAIVLDQFVR LRDGDRYWFE NTRNGLFSKK EIEDIRNTTL RDVLVAVINI
560 570 580 590 600
DPSALQPNVF VWHKGAPCPQ PKQLTTDGLP QCAPLTVLDF FEGSSPGFAI
610 620 630 640 650
TIIALCCLPL VSLLLSGVVA YFRGRERKKL QKKVKESVKK EAAKDGVPAM
660 670 680 690 700
EWPGPKERSS PIIIQLLSDR CLQVLNRRLT VLRVVQLQPL QQVNLILSNN
710 720 730 740 750
RGCRTLLLKI PKEYDLVLLF SSEEERGAFV QQLRDFCMRW ALGLHVAEMS
760 770 780 790 800
EKELFRKAVT KQQRERILEI FFRHLFAQVL DINQADAGTL PLDSCQKVRE
810 820 830 840 850
ALTCELSRAE FAESLGLKPQ DMFVESMFSL ADKDGNGYLS FREFLDILVV
860 870 880 890 900
FMKGSPEDKS RLMFTMYDLD ENGFLSKDEF FTMMRSFIEI SNNCLSKAQL
910 920 930 940 950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSELRFTQL CVKGGGGGGS
960 970 980 990 1000
GIRDIFKQNI SCRVSFITRT PGERSHPQGL GPPAPEAPEL GGPGLKKRFG
1010 1020 1030 1040 1050
KKAAVPTPRL YTEALQEKMQ RGFLAQKLQQ YKRFVENYRR HIVCVAIFSA
1060 1070 1080 1090 1100
ICVGVFADRA YYYGFASPPS DIAQTTLVGI ILSRGTAASV SFMFSYILLT
1110 1120 1130 1140 1150
MCRNLITFLR ETFLNRYVPF DAAVDFHRWI AMAAVVLAIL HSAGHAVNVY
1160 1170 1180 1190 1200
IFSVSPLSLL ACVFPNVFVN DGSKLPQKFY WWFFQTVPGM TGVLLLLVLA
1210 1220 1230 1240 1250
IMYVFASHHF RRRSFRGFWL THHLYILLYA LLIIHGSYAL IQLPTFHIYF
1260 1270 1280 1290 1300
LVPAIIYGGD KLVSLSRKKV EISVVKAELL PSGVTYLQFQ RPQGFEYKSG
1310 1320 1330 1340 1350
QWVRIACLAL GTTEYHPFTL TSAPHEDTLS LHIRAVGPWT TRLREIYSSP
1360 1370 1380 1390 1400
KGNACAGYPK LYLDGPFGEG HQEWHKFEVS VLVGGGIGVT PFASILKDLV
1410 1420 1430 1440 1450
FKSSLGSQML CKKIYFIWVT RTQRQFEWLA DIIREVEEND HQDLVSVHIY
1460 1470 1480 1490 1500
VTQLAEKFDL RTTMLYICER HFQKVLNRSL FTGLRSITHF GRPPFEPFFN
1510 1520 1530 1540
SLQEVHPQVR KIGVFSCGPP GMTKNVEKAC QLVNRQDRAH FMHHYENF
Length:1,548
Mass (Da):175,439
Last modified:February 28, 2018 - v2
Checksum:i1C1B421D0A8FAE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC186178 Genomic DNA No translation available.
NBAG03000224 Genomic DNA Translation: PNI75105.1
RefSeqiXP_009427327.1, XM_009429052.2
XP_016783637.1, XM_016928148.1

Genome annotation databases

EnsembliENSPTRT00000012972; ENSPTRP00000012012; ENSPTRG00000007026
GeneIDi453395
KEGGiptr:453395

Similar proteinsi

Entry informationi

Entry nameiH2Q9C5_PANTR
AccessioniPrimary (citable) accession number: H2Q9C5
Secondary accession number(s): A0A2J8NTJ8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: June 20, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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