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Protein
Submitted name:

Uncharacterized protein

Gene

TGM1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Note: Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei378 – 3781UniRule annotation
Active sitei437 – 4371UniRule annotation
Active sitei460 – 4601UniRule annotation
Metal bindingi500 – 5001CalciumUniRule annotation
Metal bindingi502 – 5021CalciumUniRule annotation
Metal bindingi549 – 5491CalciumUniRule annotation
Metal bindingi554 – 5541CalciumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. keratinocyte differentiation Source: Ensembl
  2. organ morphogenesis Source: Ensembl
  3. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TGM1Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. intrinsic component of membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119108.
InParanoidiH2Q827.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2Q827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDGRSRRGGG GRSFWARCCG
60 70 80 90 100
CCSCRNAADD DWGPEPSDSR GRGSSSGTRR PGSRGSDSRR PVSRGSGVNA
110 120 130 140 150
AGDGTIREGM LVVNGVDLLS SRSDQNRREH HTDEYEYDEL IVRRGQPFHM
160 170 180 190 200
LLLLSRTYES SDRITLELLI GNNPEVGKGT HVIIPVGKGG SGGWKAQVVK
210 220 230 240 250
ASGQNLNLRV HTSPNAIIGK FQFTVRTQSD AGEFQLPFDP RNEIYILFNP
260 270 280 290 300
WCPEDIVYVD HEDWRQEYVL NESGRIYYGT EAQIGERTWN YGQFDHGVLD
310 320 330 340 350
ACLYILDRRG MPYGGRGDPV SVSRVISAMV NSLDDNGVLI GNWSGDYSRG
360 370 380 390 400
TNPSAWVGSV EILLSYLRTG YSVPYGQCWV FAGVTTTVLR CLGLATRTVT
410 420 430 440 450
NFNSAHDTDT SLTMDIYFDE NMKPLEHLNH DSVWNFHVWN DCWMKRPDLP
460 470 480 490 500
SGFDGWQVVD ATPQETSSGI FCCGPCSVES IKNGLVYMKY DTPFIFAEVN
510 520 530 540 550
SDKVYWQRQD DGSFKIVYVE EKAIGTLIVT KAISSNMRED ITYLYKHPEG
560 570 580 590 600
SDAERKAVET AAAHGSKPNV YANRGSAEDV AMQVEAQDAV MGQDLMVSVM
610 620 630 640 650
LTNHSSSRRT VKLHLYLSVT FYTGVSGTIF EETKKEVELA PGASDRVTMP
660 670 680 690 700
VAYKEYRPHL VDQGAMLLNV SGHVKESGQV LAKQHTFRLR TPDLSLTLLG
710 720 730 740 750
AAVVGQECEV QIVFKNPLPV TLTNVVFRLE GSGLQRPKIL NVGDIGGNET
760 770 780 790 800
VTLRQSFVPV RPGPRQLIAS LDSPQLSQVH GVIQVDVAPA PGDGGFFSDA
810
GGDSHLGETI PMASRGGA
Length:818
Mass (Da):89,806
Last modified:March 21, 2012 - v1
Checksum:i6AA23812DAE885AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03095439 Genomic DNA. No translation available.
RefSeqiXP_009425864.1. XM_009427589.1.
XP_009425865.1. XM_009427590.1.
XP_009425866.1. XM_009427591.1.

Genome annotation databases

EnsembliENSPTRT00000011396; ENSPTRP00000010543; ENSPTRG00000006209.
GeneIDi452814.
KEGGiptr:452814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03095439 Genomic DNA. No translation available.
RefSeqiXP_009425864.1. XM_009427589.1.
XP_009425865.1. XM_009427590.1.
XP_009425866.1. XM_009427591.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000011396; ENSPTRP00000010543; ENSPTRG00000006209.
GeneIDi452814.
KEGGiptr:452814.

Organism-specific databases

CTDi7051.

Phylogenomic databases

GeneTreeiENSGT00760000119108.
InParanoidiH2Q827.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2Q827_PANTR
AccessioniPrimary (citable) accession number: H2Q827
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.