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Protein

EEF1A lysine methyltransferase 1

Gene

EEF1AKMT1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6AMT2UniRule annotation
Gene namesi
Name:EEF1AKMT1UniRule annotationImported
Synonyms:N6AMT2UniRule annotationImported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:8874 EEF1AKMT1

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Expressioni

Gene expression databases

BgeeiENSPTRG00000005687

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350 Eukaryota
ENOG4111GGY LUCA
GeneTreeiENSGT00390000016366
OMAiFAMYGEE
OrthoDBiEOG091G0GA7
TreeFamiTF106153

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYS IGIIEENWQL
60 70 80 90 100
SQFWYSQETA LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY
110 120 130 140 150
IFEYDKRFAM YGEEFIFYDY NNPLDLPERI AAHSFDIVIA DPPYLSEECL
160 170 180 190 200
RKTSETIKYL TRGKILLCTG AIMEEQAAEL LGVKMCTFVP RHTRNLANEF
210
RCYVNYDSGL DCGI
Length:214
Mass (Da):24,493
Last modified:February 28, 2018 - v2
Checksum:iCCEB5D7C10F0B127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04071644 Genomic DNA No translation available.
GABE01010998 mRNA Translation: JAA33741.1
RefSeqiXP_509564.2, XM_509564.5

Genome annotation databases

EnsembliENSPTRT00000010486; ENSPTRP00000009701; ENSPTRG00000005687
GeneIDi452464
KEGGiptr:452464

Similar proteinsi

Entry informationi

Entry nameiH2Q794_PANTR
AccessioniPrimary (citable) accession number: H2Q794
Secondary accession number(s): K7BU04
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: February 28, 2018
Last modified: April 25, 2018
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health