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Protein

EEF1A lysine methyltransferase 1

Gene

N6AMT2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6AMT2UniRule annotation
Gene namesi
Name:N6AMT2UniRule annotationImported
Synonyms:EEF1AKMT1UniRule annotation
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiH2Q794.

Expressioni

Gene expression databases

BgeeiENSPTRG00000005687.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350. Eukaryota.
ENOG4111GGY. LUCA.
GeneTreeiENSGT00390000016366.
OMAiFAMYGEE.
OrthoDBiEOG091G0GA7.
TreeFamiTF106153.

Family and domain databases

HAMAPiMF_03187. Methyltr_EFM5. 1 hit.
InterProiView protein in InterPro
IPR002052. DNA_methylase_N6_adenine_CS.
IPR019369. Efm5/EEF1AKMT1.
IPR029063. SAM-dependent_MTases.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS00092. N6_MTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

H2Q794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLEDDETP QLSAHALAAL QEFYAEQKQQ IEPGEDDKYS IGIIEENWQL
60 70 80 90 100
SQFWYSQETA LQLAQEAIAA VGEGGRIACV SAPSVYQKLR ELCRENFSIY
110 120 130 140 150
IFEYDERFAM YGEEFIFYDY NNPLDLPERI AAHSFDIVIA DPPYLSEECL
160 170 180 190 200
RKTSETIKYL TRGKILLCTG AIMEEQAAEL LGVKMCTFVP RHTRNLANEF
210
RCYVNYDSGL DCGI
Length:214
Mass (Da):24,494
Last modified:March 21, 2012 - v1
Checksum:i3CEB57D6BD906A4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ03091924 Genomic DNA. No translation available.
AACZ03091925 Genomic DNA. No translation available.
AACZ03091926 Genomic DNA. No translation available.
AACZ03091927 Genomic DNA. No translation available.
AACZ03091928 Genomic DNA. No translation available.
GABF01005179 mRNA. Translation: JAA16966.1.
GABD01007025 mRNA. Translation: JAA26075.1.

Genome annotation databases

EnsembliENSPTRT00000010486; ENSPTRP00000009701; ENSPTRG00000005687.

Similar proteinsi

Entry informationi

Entry nameiH2Q794_PANTR
AccessioniPrimary (citable) accession number: H2Q794
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: January 31, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported