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H2Q758

- H2Q758_PANTR

UniProt

H2Q758 - H2Q758_PANTR

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Protein
Submitted name:

SET domain containing (Lysine methyltransferase) 8

Gene

SETD8

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: Ensembl
  2. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. peptidyl-lysine monomethylation Source: Ensembl
  3. regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
SET domain containing (Lysine methyltransferase) 8Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SETD8Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 12

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00410000025501.
InParanoidiH2Q758.
KOiK11428.
OMAiCSGMRSP.
OrthoDBiEOG70KGRN.
TreeFamiTF335181.

Family and domain databases

InterProiIPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2Q758-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGRKMSKP RAVEAAAAAA AVAATAPGPE MVERRGPGRP RTDGENVFTG
60 70 80 90 100
QSKIYSYMSP NKCSGMRFPL QEENSVTHHE VKCQGKPLAG IYRKREEKRN
110 120 130 140 150
AGNAVRSAMK SEEQKIKDAR RGPLVPFPNQ KSEAAEPPKT PPSSCDSTNA
160 170 180 190 200
AIAKQALKKP IKGKQAPRKK AQGKTQQNRK LTDFYPVRRS SRKSKAELQS
210 220 230 240 250
EERKRIDELI ESGKEEGMKI DLIDGKGRGV IATKQFSRGD FVVEYHGDLI
260 270 280 290 300
EITDAKKREA LYAQDPSTGC YMYYFQYLSK TYCVDATRET NRLGRLINHS
310 320 330 340 350
KCGNCQTKLH DIDGVPHLIL IASRDIAAGE ELLYDYGDRS KASIEAHPWL

KH
Length:352
Mass (Da):39,251
Last modified:March 21, 2012 - v1
Checksum:i0A5AB2BE5763133C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03090014 Genomic DNA. No translation available.
AACZ03090015 Genomic DNA. No translation available.
AACZ03090016 Genomic DNA. No translation available.
AACZ03090017 Genomic DNA. No translation available.
AACZ03090018 Genomic DNA. No translation available.
GABC01002983 mRNA. Translation: JAA08355.1.
GABF01000651 mRNA. Translation: JAA21494.1.
GABE01007300 mRNA. Translation: JAA37439.1.
RefSeqiXP_509461.3. XM_509461.4.

Genome annotation databases

EnsembliENSPTRT00000010287; ENSPTRP00000009519; ENSPTRG00000005598.
GeneIDi452343.
KEGGiptr:452343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03090014 Genomic DNA. No translation available.
AACZ03090015 Genomic DNA. No translation available.
AACZ03090016 Genomic DNA. No translation available.
AACZ03090017 Genomic DNA. No translation available.
AACZ03090018 Genomic DNA. No translation available.
GABC01002983 mRNA. Translation: JAA08355.1 .
GABF01000651 mRNA. Translation: JAA21494.1 .
GABE01007300 mRNA. Translation: JAA37439.1 .
RefSeqi XP_509461.3. XM_509461.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000010287 ; ENSPTRP00000009519 ; ENSPTRG00000005598 .
GeneIDi 452343.
KEGGi ptr:452343.

Organism-specific databases

CTDi 387893.

Phylogenomic databases

GeneTreei ENSGT00410000025501.
InParanoidi H2Q758.
KOi K11428.
OMAi CSGMRSP.
OrthoDBi EOG70KGRN.
TreeFami TF335181.

Family and domain databases

InterProi IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
SMARTi SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported and Smooth vascularImported.

Entry informationi

Entry nameiH2Q758_PANTR
AccessioniPrimary (citable) accession number: H2Q758
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3