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H2Q758

- H2Q758_PANTR

UniProt

H2Q758 - H2Q758_PANTR

Protein
Submitted name:

SET domain containing (Lysine methyltransferase) 8

Gene

SETD8

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: Ensembl
    2. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. peptidyl-lysine monomethylation Source: Ensembl
    3. regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    SET domain containing (Lysine methyltransferase) 8Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:SETD8Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 12

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00410000025501.
    KOiK11428.
    OMAiCSGMRSP.
    OrthoDBiEOG70KGRN.
    TreeFamiTF335181.

    Family and domain databases

    InterProiIPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2Q758-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGRKMSKP RAVEAAAAAA AVAATAPGPE MVERRGPGRP RTDGENVFTG    50
    QSKIYSYMSP NKCSGMRFPL QEENSVTHHE VKCQGKPLAG IYRKREEKRN 100
    AGNAVRSAMK SEEQKIKDAR RGPLVPFPNQ KSEAAEPPKT PPSSCDSTNA 150
    AIAKQALKKP IKGKQAPRKK AQGKTQQNRK LTDFYPVRRS SRKSKAELQS 200
    EERKRIDELI ESGKEEGMKI DLIDGKGRGV IATKQFSRGD FVVEYHGDLI 250
    EITDAKKREA LYAQDPSTGC YMYYFQYLSK TYCVDATRET NRLGRLINHS 300
    KCGNCQTKLH DIDGVPHLIL IASRDIAAGE ELLYDYGDRS KASIEAHPWL 350
    KH 352
    Length:352
    Mass (Da):39,251
    Last modified:March 21, 2012 - v1
    Checksum:i0A5AB2BE5763133C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03090014 Genomic DNA. No translation available.
    AACZ03090015 Genomic DNA. No translation available.
    AACZ03090016 Genomic DNA. No translation available.
    AACZ03090017 Genomic DNA. No translation available.
    AACZ03090018 Genomic DNA. No translation available.
    GABC01002983 mRNA. Translation: JAA08355.1.
    GABF01000651 mRNA. Translation: JAA21494.1.
    GABE01007300 mRNA. Translation: JAA37439.1.
    RefSeqiXP_509461.3. XM_509461.4.

    Genome annotation databases

    EnsembliENSPTRT00000010287; ENSPTRP00000009519; ENSPTRG00000005598.
    GeneIDi452343.
    KEGGiptr:452343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03090014 Genomic DNA. No translation available.
    AACZ03090015 Genomic DNA. No translation available.
    AACZ03090016 Genomic DNA. No translation available.
    AACZ03090017 Genomic DNA. No translation available.
    AACZ03090018 Genomic DNA. No translation available.
    GABC01002983 mRNA. Translation: JAA08355.1 .
    GABF01000651 mRNA. Translation: JAA21494.1 .
    GABE01007300 mRNA. Translation: JAA37439.1 .
    RefSeqi XP_509461.3. XM_509461.4.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000010287 ; ENSPTRP00000009519 ; ENSPTRG00000005598 .
    GeneIDi 452343.
    KEGGi ptr:452343.

    Organism-specific databases

    CTDi 387893.

    Phylogenomic databases

    GeneTreei ENSGT00410000025501.
    KOi K11428.
    OMAi CSGMRSP.
    OrthoDBi EOG70KGRN.
    TreeFami TF335181.

    Family and domain databases

    InterProi IPR016858. Hist_H4-K20_MeTrfase.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027717. Histone_H4-K20_mtfrase. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51571. SAM_MT43_PR_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adipose stromalImported, Skeletal muscleImported and Smooth vascularImported.

    Entry informationi

    Entry nameiH2Q758_PANTR
    AccessioniPrimary (citable) accession number: H2Q758
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3