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Protein

Histone-lysine N-methyltransferase

Gene

SETD8

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei271S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:SETD8Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Expressioni

Gene expression databases

BgeeiENSPTRG00000005598

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000009519

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini216 – 337SETInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni226 – 228S-adenosyl-L-methionine bindingUniRule annotation3
Regioni298 – 299S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1085 Eukaryota
COG2940 LUCA
KOiK11428
OMAiKQFSRGE
OrthoDBiEOG091G0UBI
TreeFamiTF335181

Family and domain databases

InterProiView protein in InterPro
IPR016858 Hist_H4-K20_MeTrfase
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PIRSFiPIRSF027717 Histone_H4-K20_mtfrase, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51571 SAM_MT43_PR_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGRKMSKP RAVEAAAAAA AVAATAPGPE MVERRGPGRP RTDGENVFTG
60 70 80 90 100
QSKIYSYMSP NKCSGMRFPL QEENSVTHHE VKCQGKPLAG IYRKREEKRN
110 120 130 140 150
AGNAVRSAMK SEEQKIKDAR RGPLVPFPNQ KSEAAEPPKT PPSSCDSTNA
160 170 180 190 200
AIAKQALKKP IKGKQAPRKK AQGKTQQNRK LTDFYPVRRS SRKSKAELQS
210 220 230 240 250
EERKRIDELI ESGKEEGMKI DLIDGKGRGV IATKQFSRGD FVVEYHGDLI
260 270 280 290 300
EITDAKKREA LYAQDPSTGC YMYYFQYLSK TYCVDATRET NRLGRLINHS
310 320 330 340 350
KCGNCQTKLH DIDGVPHLIL IASRDIAAGE ELLYDYGDRS KASIEAHPWL

KH
Length:352
Mass (Da):39,251
Last modified:March 21, 2012 - v1
Checksum:i0A5AB2BE5763133C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GABC01002983 mRNA Translation: JAA08355.1
GABF01000651 mRNA Translation: JAA21494.1
GABE01007300 mRNA Translation: JAA37439.1
RefSeqiXP_016780030.1, XM_016924541.1

Genome annotation databases

GeneIDi107967672
KEGGiptr:107967672

Similar proteinsi

Entry informationi

Entry nameiH2Q758_PANTR
AccessioniPrimary (citable) accession number: H2Q758
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 25, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health