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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

GPD1

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41NADUniRule annotation1
Binding sitei97NADUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei153NAD; via amide nitrogenUniRule annotation1
Active sitei204Proton acceptorUniRule annotation1
Binding sitei269NADUniRule annotation1
Binding sitei296NAD; via amide nitrogenUniRule annotation1
Binding sitei298NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
Name:GPD1Imported
ORF Names:CK820_G0039680Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:5405 GPD1

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiH2Q5W6

Expressioni

Gene expression databases

BgeeiENSPTRG00000004925

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000008412

Structurei

3D structure databases

ProteinModelPortaliH2Q5W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 172NAD_Gly3P_dh_NInterPro annotationAdd BLAST168
Domaini194 – 339NAD_Gly3P_dh_CInterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni269 – 270Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
InParanoidiH2Q5W6
KOiK00006
OMAiWLCKGFE
OrthoDBiEOG091G0DO6
TreeFamiTF300836

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

H2Q5W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL
60 70 80 90 100
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK
110 120 130 140 150
ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA
160 170 180 190 200
NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC
210 220 230 240 250
GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGPVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP
310 320 330 340
ETARELHSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM
Length:349
Mass (Da):37,542
Last modified:March 21, 2012 - v1
Checksum:iCE7B62C4047576EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACZ04012902 Genomic DNA No translation available.
AACZ04012903 Genomic DNA No translation available.
AACZ04012904 Genomic DNA No translation available.
NBAG03000375 Genomic DNA Translation: PNI33293.1
RefSeqiXP_001154939.1, XM_001154939.4

Genome annotation databases

EnsembliENSPTRT00000009103; ENSPTRP00000008412; ENSPTRG00000004925
GeneIDi741054
KEGGiptr:741054

Similar proteinsi

Entry informationi

Entry nameiH2Q5W6_PANTR
AccessioniPrimary (citable) accession number: H2Q5W6
Secondary accession number(s): A0A2J8KE46
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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