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H2Q0S9

- H2Q0S9_PANTR

UniProt

H2Q0S9 - H2Q0S9_PANTR

Protein
Submitted name:

Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)

Gene

PTGS2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heme binding Source: Ensembl
    2. peroxidase activity Source: InterPro
    3. prostaglandin-endoperoxide synthase activity Source: Ensembl

    GO - Biological processi

    1. anagen Source: Ensembl
    2. brown fat cell differentiation Source: Ensembl
    3. cellular response to hypoxia Source: Ensembl
    4. cyclooxygenase pathway Source: Ensembl
    5. positive regulation of brown fat cell differentiation Source: Ensembl
    6. positive regulation of fever generation Source: Ensembl
    7. regulation of blood pressure Source: Ensembl
    8. regulation of cell proliferation Source: Ensembl
    9. response to oxidative stress Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:PTGS2Imported
    OrganismiPan troglodytes (Chimpanzee)Imported
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. neuron projection Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000010743.
    KOiK11987.
    OMAiICNNVKG.
    OrthoDBiEOG7RFTHC.
    TreeFamiTF329675.

    Family and domain databases

    Gene3Di1.10.640.10. 1 hit.
    InterProiIPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view]
    PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
    PfamiPF03098. An_peroxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2Q0S9-1 [UniParc]FASTAAdd to Basket

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    MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY    50
    GENCSTPEFL TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS 100
    YVLTSRSHLI DSPPTYNADY GYKSWEAFSN LSYYTRALPP VPDDCPTPLG 150
    VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS NMMFAFFAQH FTHQFFKTDH 200
    KRGPAFTNGL GHGVDLNHIY GETLARQHKL RLFKDGKMKY QIIDGEMYPP 250
    TVKDTQAEMI YPPQVPEHLR FAVGQEFFGL VPGLMMYATI WLREHNRVCD 300
    VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE 350
    LLFNKQFQYQ NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL 400
    LEHGITQFVE SFTRQIAGRV AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN 450
    EYRKRFMLKP YESFEELTGE KEMSAELEAL YGDIDAVELY PALLVEKPRP 500
    DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV GFQIINTASI 550
    QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER 600
    STEL 604
    Length:604
    Mass (Da):69,025
    Last modified:March 21, 2012 - v1
    Checksum:i0362AC245F1785E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03000255 Genomic DNA. No translation available.
    GABC01002551 mRNA. Translation: JAA08787.1.
    GABF01006138 mRNA. Translation: JAA16007.1.
    GABE01001405 mRNA. Translation: JAA43334.1.
    RefSeqiXP_524999.3. XM_524999.4.

    Genome annotation databases

    EnsembliENSPTRT00000003246; ENSPTRP00000002990; ENSPTRG00000001786.
    GeneIDi469616.
    KEGGiptr:469616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACZ03000255 Genomic DNA. No translation available.
    GABC01002551 mRNA. Translation: JAA08787.1 .
    GABF01006138 mRNA. Translation: JAA16007.1 .
    GABE01001405 mRNA. Translation: JAA43334.1 .
    RefSeqi XP_524999.3. XM_524999.4.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000003246 ; ENSPTRP00000002990 ; ENSPTRG00000001786 .
    GeneIDi 469616.
    KEGGi ptr:469616.

    Organism-specific databases

    CTDi 5743.

    Phylogenomic databases

    GeneTreei ENSGT00390000010743.
    KOi K11987.
    OMAi ICNNVKG.
    OrthoDBi EOG7RFTHC.
    TreeFami TF329675.

    Family and domain databases

    Gene3Di 1.10.640.10. 1 hit.
    InterProi IPR029576. COX-2.
    IPR000742. EG-like_dom.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    [Graphical view ]
    PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
    Pfami PF03098. An_peroxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS50026. EGF_3. 1 hit.
    PS50292. PEROXIDASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
      Chimpanzee sequencing and analysis consortium
      Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
    3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
      Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
      Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Adipose stromalImported, Skeletal muscleImported and Smooth vascularImported.

    Entry informationi

    Entry nameiH2Q0S9_PANTR
    AccessioniPrimary (citable) accession number: H2Q0S9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3