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H2Q0S9

- H2Q0S9_PANTR

UniProt

H2Q0S9 - H2Q0S9_PANTR

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Protein
Submitted name:

Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)

Gene

PTGS2

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: Ensembl
  2. peroxidase activity Source: InterPro
  3. prostaglandin-endoperoxide synthase activity Source: Ensembl

GO - Biological processi

  1. anagen Source: Ensembl
  2. brown fat cell differentiation Source: Ensembl
  3. cellular response to hypoxia Source: Ensembl
  4. cyclooxygenase pathway Source: Ensembl
  5. inflammatory response Source: InterPro
  6. positive regulation of brown fat cell differentiation Source: Ensembl
  7. positive regulation of fever generation Source: Ensembl
  8. regulation of blood pressure Source: Ensembl
  9. regulation of cell proliferation Source: Ensembl
  10. response to oxidative stress Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase)Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PTGS2Imported
OrganismiPan troglodytes (Chimpanzee)Imported
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. neuron projection Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000010743.
InParanoidiH2Q0S9.
KOiK11987.
OMAiICNNVKG.
OrthoDBiEOG7RFTHC.
TreeFamiTF329675.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2Q0S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS
110 120 130 140 150
YVLTSRSHLI DSPPTYNADY GYKSWEAFSN LSYYTRALPP VPDDCPTPLG
160 170 180 190 200
VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTNGL GHGVDLNHIY GETLARQHKL RLFKDGKMKY QIIDGEMYPP
260 270 280 290 300
TVKDTQAEMI YPPQVPEHLR FAVGQEFFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNKQFQYQ NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL
410 420 430 440 450
LEHGITQFVE SFTRQIAGRV AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN
460 470 480 490 500
EYRKRFMLKP YESFEELTGE KEMSAELEAL YGDIDAVELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV GFQIINTASI
560 570 580 590 600
QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):69,025
Last modified:March 21, 2012 - v1
Checksum:i0362AC245F1785E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03000255 Genomic DNA. No translation available.
GABC01002551 mRNA. Translation: JAA08787.1.
GABF01006138 mRNA. Translation: JAA16007.1.
GABE01001405 mRNA. Translation: JAA43334.1.
RefSeqiXP_524999.3. XM_524999.4.

Genome annotation databases

EnsembliENSPTRT00000003246; ENSPTRP00000002990; ENSPTRG00000001786.
GeneIDi469616.
KEGGiptr:469616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACZ03000255 Genomic DNA. No translation available.
GABC01002551 mRNA. Translation: JAA08787.1 .
GABF01006138 mRNA. Translation: JAA16007.1 .
GABE01001405 mRNA. Translation: JAA43334.1 .
RefSeqi XP_524999.3. XM_524999.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000003246 ; ENSPTRP00000002990 ; ENSPTRG00000001786 .
GeneIDi 469616.
KEGGi ptr:469616.

Organism-specific databases

CTDi 5743.

Phylogenomic databases

GeneTreei ENSGT00390000010743.
InParanoidi H2Q0S9.
KOi K11987.
OMAi ICNNVKG.
OrthoDBi EOG7RFTHC.
TreeFami TF329675.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Initial sequence of the chimpanzee genome and comparison with the human genome."
    Chimpanzee sequencing and analysis consortium
    Nature 437:69-87(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "De novo assembly of the reference chimpanzee transcriptome from NextGen mRNA sequences."
    Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.
    Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adipose stromalImported, Skeletal muscleImported and Smooth vascularImported.

Entry informationi

Entry nameiH2Q0S9_PANTR
AccessioniPrimary (citable) accession number: H2Q0S9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3