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Protein

mRNA-capping enzyme

Gene

RNGTT

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.UniRule annotation

Catalytic activityi

A 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate.UniRule annotation
GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66For RNA 5'-triphosphatase activityUniRule annotation1
Active sitei234N6-GMP-lysine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processmRNA cappingUniRule annotation, mRNA processing
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-capping enzymeUniRule annotation
Including the following 2 domains:
Polynucleotide 5'-triphosphataseUniRule annotation (EC:3.1.3.33UniRule annotation)
mRNA guanylyltransferaseUniRule annotation (EC:2.7.7.50UniRule annotation)
Alternative name(s):
GTP--RNA guanylyltransferaseUniRule annotation
Short name:
GTaseUniRule annotation
Gene namesi
Name:RNGTTImported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000018847

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 111TYR_PHOSPHATASE_2InterPro annotationAdd BLAST68

Sequence similaritiesi

In the C-terminal section; belongs to the eukaryotic GTase family.UniRule annotation
In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00530000063473
InParanoidiH2PJS8
KOiK13917
OMAiKIIECTF
OrthoDBiEOG091G063D
TreeFamiTF314914

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR017074 mRNA_cap_enz_bifunc
IPR001339 mRNA_cap_enzyme
IPR013846 mRNA_cap_enzyme_C
IPR012340 NA-bd_OB-fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF03919 mRNA_cap_C, 1 hit
PF01331 mRNA_cap_enzyme, 1 hit
PIRSFiPIRSF036958 mRNA_capping_HCE, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

H2PJS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLVDLTNT SRFYDRNDIE KEGIKYIKLQ CKGHGECPTT ENTETFIRLC
60 70 80 90 100
ERFNERNPPE LIGVHCTHGF NRTGFLICAF LVEKMDWSIE AAVATFAQAR
110 120 130 140 150
PPGIYKGDYL KELFRRYGDI EEAPPPPLLP DWCFEDDEDE DEDEDGKKES
160 170 180 190 200
EPGSSASFGK RRKERLKLGA IFLEGVTVKG VTQVTTQPKL GEVQQKCHQF
210 220 230 240 250
CGWEGSGFPG AQPVSMDKQN IKLLDLKPYK VSWKADGTRY MMLIDGTNEV
260 270 280 290 300
FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL
310 320 330 340 350
IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEPFSV
360 370 380 390 400
RNKPFFDICT SRKLLEGNFA KEVSHEMDGL IFQPTGKYKP GRCDDILKWK
410 420 430 440 450
PPSLNSVDFR LKITRMGGEG LLPQNVGLLY VGGYERPFAQ IKVTKELKQY
460 470 480 490 500
DNKIIECKFE NNSWVFMRQR TDKSFPNAYN TAMAVCNSIS NPVTKEMLFE
510 520 530
FIDRCTAASQ GQKRKHHLDP DTELMPPPPP KRPRPLT
Length:537
Mass (Da):61,599
Last modified:January 9, 2013 - v2
Checksum:iF53D857E6AFBDAE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01027263 Genomic DNA No translation available.
ABGA01027264 Genomic DNA No translation available.
ABGA01027265 Genomic DNA No translation available.
ABGA01027266 Genomic DNA No translation available.
ABGA01027267 Genomic DNA No translation available.
ABGA01027268 Genomic DNA No translation available.
ABGA01027269 Genomic DNA No translation available.
ABGA01027270 Genomic DNA No translation available.
ABGA01027271 Genomic DNA No translation available.
ABGA01027272 Genomic DNA No translation available.
RefSeqiXP_009240354.1, XM_009242079.1

Genome annotation databases

EnsembliENSPPYT00000019591; ENSPPYP00000018847; ENSPPYG00000016834
KEGGipon:100439097

Similar proteinsi

Entry informationi

Entry nameiH2PJS8_PONAB
AccessioniPrimary (citable) accession number: H2PJS8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: April 25, 2018
This is version 38 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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