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H2PEC4

- H2PEC4_PONAB

UniProt

H2PEC4 - H2PEC4_PONAB

Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. peptidyl-lysine dimethylation Source: Ensembl
    2. peptidyl-lysine monomethylation Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation, Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD7UniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    SET domain-containing protein 7UniRule annotation
    Gene namesi
    Name:SETD7Imported
    OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
    Taxonomic identifieri9601 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
    ProteomesiUP000001595: Chromosome 4

    Subcellular locationi

    Nucleus UniRule annotation. Chromosome UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.UniRule annotation
    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000004827.
    KOiK11431.
    OMAiGSSVYHF.
    OrthoDBiEOG7M98G8.
    TreeFamiTF106392.

    Family and domain databases

    InterProiIPR017155. Hist-Lys_N-MeTrfase_SET.
    IPR003409. MORN.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF02493. MORN. 4 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51577. SAM_MT43_SET7. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2PEC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK    50
    FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT 100
    DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GDVNEDGEMT GEKIAYVYPD 150
    ERTALYGKFI DGEMIEGKLA TLTSTEEGRP HFELMPGNSV YHFDKSTSSC 200
    ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI 250
    THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT 300
    PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP 350
    EWYQVELKAF QATQQK 366
    Length:366
    Mass (Da):40,677
    Last modified:March 21, 2012 - v1
    Checksum:iC122E075C80C9D17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGA01062183 Genomic DNA. No translation available.
    ABGA01062184 Genomic DNA. No translation available.
    ABGA01062185 Genomic DNA. No translation available.
    ABGA01062186 Genomic DNA. No translation available.
    ABGA01062187 Genomic DNA. No translation available.
    RefSeqiXP_002815202.1. XM_002815156.1.

    Genome annotation databases

    EnsembliENSPPYT00000017520; ENSPPYP00000016839; ENSPPYG00000015073.
    GeneIDi100449956.
    KEGGipon:100449956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ABGA01062183 Genomic DNA. No translation available.
    ABGA01062184 Genomic DNA. No translation available.
    ABGA01062185 Genomic DNA. No translation available.
    ABGA01062186 Genomic DNA. No translation available.
    ABGA01062187 Genomic DNA. No translation available.
    RefSeqi XP_002815202.1. XM_002815156.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPPYT00000017520 ; ENSPPYP00000016839 ; ENSPPYG00000015073 .
    GeneIDi 100449956.
    KEGGi pon:100449956.

    Organism-specific databases

    CTDi 80854.

    Phylogenomic databases

    GeneTreei ENSGT00390000004827.
    KOi K11431.
    OMAi GSSVYHF.
    OrthoDBi EOG7M98G8.
    TreeFami TF106392.

    Family and domain databases

    InterProi IPR017155. Hist-Lys_N-MeTrfase_SET.
    IPR003409. MORN.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF02493. MORN. 4 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51577. SAM_MT43_SET7. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
      Wilson R.K., Mardis E.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiH2PEC4_PONAB
    AccessioniPrimary (citable) accession number: H2PEC4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3