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Protein

Histone-lysine N-methyltransferase SETD7

Gene

SETD7

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation, Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD7UniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
SET domain-containing protein 7UniRule annotation
Gene namesi
Name:SETD7Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 4

Subcellular locationi

  • Nucleus UniRule annotation
  • Chromosome UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.UniRule annotation
Contains 1 SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004827.
InParanoidiH2PEC4.
KOiK11431.
OMAiGSSVYHF.
OrthoDBiEOG7M98G8.
TreeFamiTF106392.

Family and domain databases

InterProiIPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
[Graphical view]
PfamiPF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2PEC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK
60 70 80 90 100
FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT
110 120 130 140 150
DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GDVNEDGEMT GEKIAYVYPD
160 170 180 190 200
ERTALYGKFI DGEMIEGKLA TLTSTEEGRP HFELMPGNSV YHFDKSTSSC
210 220 230 240 250
ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI
260 270 280 290 300
THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
310 320 330 340 350
PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP
360
EWYQVELKAF QATQQK
Length:366
Mass (Da):40,677
Last modified:March 21, 2012 - v1
Checksum:iC122E075C80C9D17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01062183 Genomic DNA. No translation available.
ABGA01062184 Genomic DNA. No translation available.
ABGA01062185 Genomic DNA. No translation available.
ABGA01062186 Genomic DNA. No translation available.
ABGA01062187 Genomic DNA. No translation available.
RefSeqiXP_002815202.1. XM_002815156.2.

Genome annotation databases

EnsembliENSPPYT00000017520; ENSPPYP00000016839; ENSPPYG00000015073.
GeneIDi100449956.
KEGGipon:100449956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01062183 Genomic DNA. No translation available.
ABGA01062184 Genomic DNA. No translation available.
ABGA01062185 Genomic DNA. No translation available.
ABGA01062186 Genomic DNA. No translation available.
ABGA01062187 Genomic DNA. No translation available.
RefSeqiXP_002815202.1. XM_002815156.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000017520; ENSPPYP00000016839; ENSPPYG00000015073.
GeneIDi100449956.
KEGGipon:100449956.

Organism-specific databases

CTDi80854.

Phylogenomic databases

GeneTreeiENSGT00390000004827.
InParanoidiH2PEC4.
KOiK11431.
OMAiGSSVYHF.
OrthoDBiEOG7M98G8.
TreeFamiTF106392.

Family and domain databases

InterProiIPR017155. Hist-Lys_N-MeTrfase_SET.
IPR003409. MORN.
IPR001214. SET_dom.
[Graphical view]
PfamiPF02493. MORN. 4 hits.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF037249. Histone_Lys_mtfrase_SET. 1 hit.
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51577. SAM_MT43_SET7. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2PEC4_PONAB
AccessioniPrimary (citable) accession number: H2PEC4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 27, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.