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Protein

Protein kinase C

Gene

PRKCI

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase CSAAS annotation (EC:2.7.11.13SAAS annotation)
Gene namesi
Name:PRKCIImported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 202PB1InterPro annotationAdd BLAST84
Domaini234 – 284Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini348 – 616Protein kinaseInterPro annotationAdd BLAST269
Domaini617 – 688AGC-kinase C-terminalInterPro annotationAdd BLAST72

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG0695. Eukaryota.
ENOG410ZMG2. LUCA.
GeneTreeiENSGT00820000126964.
OMAiKGDIMIT.
OrthoDBiEOG091G03Q9.
TreeFamiTF102004.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd06404. PB1_aPKC. 1 hit.
cd05618. STKc_aPKC_iota. 1 hit.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR034661. aPKC_iota.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom_sf.
IPR034877. PB1_aPKC.
IPR000270. PB1_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00130. C1_1. 1 hit.
PF00564. PB1. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiView protein in SMART
SM00109. C1. 1 hit.
SM00666. PB1. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS51745. PB1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H2PBZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWAFGASEVG GTDAGGVLGP GGCRGGGAYG QWEEPRGSGC SGEATLGSAL
60 70 80 90 100
RARGAGRWAD GRGSPTGAGG GVPHGVRSAP PHPRPPALRR GSEEMPTQRD
110 120 130 140 150
SSTMSHTVAG GGSGDHSHQV RVKAYYRGDI MITHFEPSIS FEGLCNEVRD
160 170 180 190 200
MCSFDNEQLF TMKWIYDEGD PCTVSSQLEL EEAFRLYELN KDSELLIHVF
210 220 230 240 250
PCVPERPGMP CPGEDKSIYR RGARRWRKLY CANGHTFQAK RFNRRAHCAI
260 270 280 290 300
CTDRIWGLGR QGYKCINCKL LVHKKCHKLV TIECGRHSLP PEPMMPMDQS
310 320 330 340 350
SMHSDHAQTV IPYNPSSHES LDQVGEEKEA MNTRESGKAS SSLGLQDFDL
360 370 380 390 400
LRVIGRGSYA KVLLVRLKKT DRIYAMKVVK KELVNDDEDI DWVQTEKHVF
410 420 430 440 450
EQASNHPFLV GLHSCFQTES RLFFVIEYVN GGDLMFHMQR QRKLPEEHAR
460 470 480 490 500
FYSAEISLAL NYLHERGIIY RDLKLDNVLL DSEGHIKLTD YGMCKEGLRP
510 520 530 540 550
GDTTSTFCGT PNYIAPEILR GEDYGFSVDW WALGVLMFEM MAGRSPFDIV
560 570 580 590 600
GSSDNPDQNT EDYLFQVILE KQIRIPRSLS VKAASVLKSF LNKDPKERLG
610 620 630 640 650
CHPQTGFADI QGHPFFRNVD WDMMEQKQVV PPFKPNISGE FGLDNFDSQF
660 670 680 690
TNEPVQLTPD DDDIVRKIDQ SEFEGFEYIN PLLMSAEECV
Length:690
Mass (Da):77,445
Last modified:January 9, 2013 - v2
Checksum:i060041E7267ABF5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01041970 Genomic DNA. No translation available.
ABGA01041971 Genomic DNA. No translation available.
ABGA01041972 Genomic DNA. No translation available.
ABGA01041973 Genomic DNA. No translation available.
ABGA01041974 Genomic DNA. No translation available.
ABGA01041975 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSPPYT00000016611; ENSPPYP00000015972; ENSPPYG00000014289.

Similar proteinsi

Entry informationi

Entry nameiH2PBZ2_PONAB
AccessioniPrimary (citable) accession number: H2PBZ2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: November 22, 2017
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported