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H2PA76

- H2PA76_PONAB

UniProt

H2PA76 - H2PA76_PONAB

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Protein
Submitted name:

Uncharacterized protein

Gene

SETMAR

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. endonuclease activity Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. structure-specific DNA binding Source: Ensembl
  4. transposase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: Ensembl
  2. DNA double-strand break processing Source: Ensembl
  3. DNA integration Source: InterPro
  4. negative regulation of cell cycle arrest Source: Ensembl
  5. negative regulation of chromosome organization Source: Ensembl
  6. positive regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
  7. transposition, DNA-mediated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SETMARImported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 3

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation
Contains pre-SET domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118855.
InParanoidiH2PA76.
KOiK11433.
OMAiRRRSAQW.
OrthoDBiEOG744T8D.
TreeFamiTF352220.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR001888. Transposase_1.
IPR002492. Transposase_Tc1-like.
[Graphical view]
PfamiPF01498. HTH_Tnp_Tc3_2. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF01359. Transposase_1. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2PA76 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP
60 70 80 90 100
FQYTPDHVVG PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS
110 120 130 140 150
CLRDIGSGGK YAEPVFECNV LCQCSDHCRN RVVQKGLQFH FQVFKTHKKG
160 170 180 190 200
WGLRTLEFIS KGRFVCEYAG EVLGFSEVQR RIHLQTKSDS NYIIAIREHV
210 220 230 240 250
YNGQVMETFV DPTYIGNIGR FLNHSCEPNL LMIPVRIDSM VPKLALFAAK
260 270 280 290 300
DIVPEEELSY DYSGRYLNLT GSEDKERLDN GKLRKPCYCG AKSCTAFLPF
310 320 330 340 350
DSSLYCPLEK SNISCGNEKE PSMCGSAPSV FPSCKRLTLE TMKMMLDKKQ
360 370 380 390 400
IRAIFLFEFK MGRKAAETTR NINNAFGPGT ANERTVQWWF KKFCKGDESL
410 420 430 440 450
EDEERSGRPS EVDNDQLRAI IEADPLTTTR EVAEELNVNH STVVRHLKQI
460 470 480 490 500
GKVKKLDKWV PHELTENQKN RRFEVSSSLI LRNHNEPFLD RIVTCDEKWI
510 520 530 540 550
LYDNRRRSAQ WLDQEEAPKH FPKPILHPKK VMVTIWWSAA GLIHYSFLNP
560 570 580 590 600
GETITSEKYA QEIDEMHQKL QRLQLALVNR KGPILLHDNA RPHVAQPTLQ
610 620 630 640 650
KLNELGYEVL PHPPYSPDLL PTNYHVFKHL NNFLQGKRFH NQQDAENAFQ
660 670 680
EFVKSRSTDF YATGINQLIS RWQKCVDCNG SYFD
Length:684
Mass (Da):77,995
Last modified:March 21, 2012 - v1
Checksum:iDA995A4A4B24B1ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01372566 Genomic DNA. No translation available.
ABGA01372567 Genomic DNA. No translation available.
ABGA01372568 Genomic DNA. No translation available.
ABGA01372569 Genomic DNA. No translation available.
RefSeqiXP_002813545.1. XM_002813499.2.

Genome annotation databases

EnsembliENSPPYT00000015930; ENSPPYP00000015320; ENSPPYG00000013699.
GeneIDi100447656.
KEGGipon:100447656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01372566 Genomic DNA. No translation available.
ABGA01372567 Genomic DNA. No translation available.
ABGA01372568 Genomic DNA. No translation available.
ABGA01372569 Genomic DNA. No translation available.
RefSeqi XP_002813545.1. XM_002813499.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000015930 ; ENSPPYP00000015320 ; ENSPPYG00000013699 .
GeneIDi 100447656.
KEGGi pon:100447656.

Organism-specific databases

CTDi 6419.

Phylogenomic databases

GeneTreei ENSGT00760000118855.
InParanoidi H2PA76.
KOi K11433.
OMAi RRRSAQW.
OrthoDBi EOG744T8D.
TreeFami TF352220.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR001888. Transposase_1.
IPR002492. Transposase_Tc1-like.
[Graphical view ]
Pfami PF01498. HTH_Tnp_Tc3_2. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF01359. Transposase_1. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2PA76_PONAB
AccessioniPrimary (citable) accession number: H2PA76
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3