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H2PA76

- H2PA76_PONAB

UniProt

H2PA76 - H2PA76_PONAB

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Protein
Submitted name:

Uncharacterized protein

Gene
SETMAR
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. endonuclease activity Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. structure-specific DNA binding Source: Ensembl
  4. transposase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA catabolic process, endonucleolytic Source: Ensembl
  2. DNA double-strand break processing Source: Ensembl
  3. DNA integration Source: InterPro
  4. negative regulation of cell cycle arrest Source: Ensembl
  5. negative regulation of chromosome organization Source: Ensembl
  6. positive regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
  7. transposition, DNA-mediated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SETMARImported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 3

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotations, NucleusUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations
Contains pre-SET domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117632.
KOiK11433.
OMAiRRRSAQW.
OrthoDBiEOG744T8D.
TreeFamiTF352220.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR001888. Transposase_1.
IPR002492. Transposase_Tc1-like.
[Graphical view]
PfamiPF01498. HTH_Tnp_Tc3_2. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF01359. Transposase_1. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2PA76-1 [UniParc]FASTAAdd to Basket

« Hide

MFAEAAKTTR PCGMAEFKEK PEAPTEQLDV ACGQENLPVG AWPPGAAPAP    50
FQYTPDHVVG PGADIDPTQI TFPGCICVKT PCLPGTCSCL RHGENYDDNS 100
CLRDIGSGGK YAEPVFECNV LCQCSDHCRN RVVQKGLQFH FQVFKTHKKG 150
WGLRTLEFIS KGRFVCEYAG EVLGFSEVQR RIHLQTKSDS NYIIAIREHV 200
YNGQVMETFV DPTYIGNIGR FLNHSCEPNL LMIPVRIDSM VPKLALFAAK 250
DIVPEEELSY DYSGRYLNLT GSEDKERLDN GKLRKPCYCG AKSCTAFLPF 300
DSSLYCPLEK SNISCGNEKE PSMCGSAPSV FPSCKRLTLE TMKMMLDKKQ 350
IRAIFLFEFK MGRKAAETTR NINNAFGPGT ANERTVQWWF KKFCKGDESL 400
EDEERSGRPS EVDNDQLRAI IEADPLTTTR EVAEELNVNH STVVRHLKQI 450
GKVKKLDKWV PHELTENQKN RRFEVSSSLI LRNHNEPFLD RIVTCDEKWI 500
LYDNRRRSAQ WLDQEEAPKH FPKPILHPKK VMVTIWWSAA GLIHYSFLNP 550
GETITSEKYA QEIDEMHQKL QRLQLALVNR KGPILLHDNA RPHVAQPTLQ 600
KLNELGYEVL PHPPYSPDLL PTNYHVFKHL NNFLQGKRFH NQQDAENAFQ 650
EFVKSRSTDF YATGINQLIS RWQKCVDCNG SYFD 684
Length:684
Mass (Da):77,995
Last modified:March 21, 2012 - v1
Checksum:iDA995A4A4B24B1ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01372566 Genomic DNA. No translation available.
ABGA01372567 Genomic DNA. No translation available.
ABGA01372568 Genomic DNA. No translation available.
ABGA01372569 Genomic DNA. No translation available.
RefSeqiXP_002813545.1. XM_002813499.2.

Genome annotation databases

EnsembliENSPPYT00000015930; ENSPPYP00000015320; ENSPPYG00000013699.
GeneIDi100447656.
KEGGipon:100447656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01372566 Genomic DNA. No translation available.
ABGA01372567 Genomic DNA. No translation available.
ABGA01372568 Genomic DNA. No translation available.
ABGA01372569 Genomic DNA. No translation available.
RefSeqi XP_002813545.1. XM_002813499.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000015930 ; ENSPPYP00000015320 ; ENSPPYG00000013699 .
GeneIDi 100447656.
KEGGi pon:100447656.

Organism-specific databases

CTDi 6419.

Phylogenomic databases

GeneTreei ENSGT00750000117632.
KOi K11433.
OMAi RRRSAQW.
OrthoDBi EOG744T8D.
TreeFami TF352220.

Family and domain databases

InterProi IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR001888. Transposase_1.
IPR002492. Transposase_Tc1-like.
[Graphical view ]
Pfami PF01498. HTH_Tnp_Tc3_2. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PF01359. Transposase_1. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2PA76_PONAB
AccessioniPrimary (citable) accession number: H2PA76
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 16, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi