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Protein
Submitted name:

Uncharacterized protein

Gene

IDH2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:IDH2Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012547.
InParanoidiH2NP64.
OMAiWTQAITI.
OrthoDBiEOG7QNVKS.
TreeFamiTF300428.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2NP64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERVSLASG SANPPALIPL AGPGGSHACS SCGAGISAAP REEPAGPGRR
60 70 80 90 100
VPTPAGRWTR RRPWPRLLPG KAQWGGGPGS PAPVVSARPA PARPSVNPRS
110 120 130 140 150
GSREERRALG PLPPCLFALL LGMAGYLRVV RSLCRASGSR PAWAPAALTA
160 170 180 190 200
PTSQEQPRRH YADRRIKVAK PVVEMDGDEM TRIIWQFIKE KLILPHVDIQ
210 220 230 240 250
LKYFDLGLPN RDQTDDQVTI DSALATQKYS VAVKCATITP DEARVEEFKL
260 270 280 290 300
KKMWKSPNGT IRNILGGTVF REPIICKNIP RLVPGWTKPI TIGRHAHGDQ
310 320 330 340 350
YKATDFVADR AGTFKMVFTP KDGSGVKEWE VYNFPAGGVG VGMYNTDESI
360 370 380 390 400
SGFAHSCFQY AIQKKWPLYM STKNTILKAY DGRFKDIFQE IFDKHYKTDF
410 420 430 440 450
DKNKIWYEHR LIDDMVAQVL KSSGGFVWAC KNYDGDVQSD ILAQGFGSLG
460 470 480 490 500
LMTSVLVCPD GKTIEAEAAH GTVTRHYREH QKGRPTSTNP IASIFAWTRG
510 520 530 540 550
LEHRGKLDGN QDLIRFAQTL EKVCVETVES GAMTKDLAGC IHGLSNVKLN
560 570
EHFLNTTDFL DTIKSNLDRA LGRQ
Length:574
Mass (Da):63,273
Last modified:January 8, 2013 - v2
Checksum:i738C607EC0506A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01164031 Genomic DNA. No translation available.
ABGA01164032 Genomic DNA. No translation available.
ABGA01164033 Genomic DNA. No translation available.
ABGA01164034 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSPPYT00000007998; ENSPPYP00000007685; ENSPPYG00000006775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01164031 Genomic DNA. No translation available.
ABGA01164032 Genomic DNA. No translation available.
ABGA01164033 Genomic DNA. No translation available.
ABGA01164034 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPPYT00000007998; ENSPPYP00000007685; ENSPPYG00000006775.

Phylogenomic databases

GeneTreeiENSGT00390000012547.
InParanoidiH2NP64.
OMAiWTQAITI.
OrthoDBiEOG7QNVKS.
TreeFamiTF300428.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2NP64_PONAB
AccessioniPrimary (citable) accession number: H2NP64
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2012
Last sequence update: January 8, 2013
Last modified: March 3, 2015
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.