ID H2NN08_PONAB Unreviewed; 720 AA. AC H2NN08; A0A2J8S5C5; A0A663D744; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 27-MAR-2024, entry version 64. DE SubName: Full=TGM5 isoform 2 {ECO:0000313|EMBL:PNJ15975.1}; DE SubName: Full=Transglutaminase 5 {ECO:0000313|Ensembl:ENSPPYP00000007261.1}; GN Name=TGM5 {ECO:0000313|Ensembl:ENSPPYP00000007261.1}; GN ORFNames=CR201_G0045991 {ECO:0000313|EMBL:PNJ15975.1}; OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pongo. OX NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000007261.1, ECO:0000313|Proteomes:UP000001595}; RN [1] {ECO:0000313|Ensembl:ENSPPYP00000007261.1, ECO:0000313|Proteomes:UP000001595} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wilson R.K., Mardis E.; RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."; RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:PNJ15975.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Susie {ECO:0000313|EMBL:PNJ15975.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M., RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J., RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M., RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B., RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSPPYP00000007261.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2}; CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2}; CC -!- SIMILARITY: Belongs to the transglutaminase superfamily. CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NDHI03003606; PNJ15975.1; -; Genomic_DNA. DR RefSeq; XP_002825414.1; XM_002825368.3. DR STRING; 9601.ENSPPYP00000007261; -. DR Ensembl; ENSPPYT00000007562.2; ENSPPYP00000007261.1; ENSPPYG00000006408.2. DR GeneID; 100459707; -. DR KEGG; pon:100459707; -. DR CTD; 9333; -. DR eggNOG; ENOG502QTRA; Eukaryota. DR GeneTree; ENSGT01050000244866; -. DR HOGENOM; CLU_013435_1_0_1; -. DR OMA; RSSWNNV; -. DR OrthoDB; 5344745at2759; -. DR TreeFam; TF324278; -. DR Proteomes; UP000001595; Chromosome 15. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro. DR Gene3D; 2.60.40.10; Immunoglobulins; 3. DR Gene3D; 3.90.260.10; Transglutaminase-like; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR014756; Ig_E-set. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR InterPro; IPR002931; Transglutaminase-like. DR InterPro; IPR036985; Transglutaminase-like_sf. DR InterPro; IPR023608; Transglutaminase_animal. DR InterPro; IPR013808; Transglutaminase_AS. DR InterPro; IPR008958; Transglutaminase_C. DR InterPro; IPR036238; Transglutaminase_C_sf. DR InterPro; IPR001102; Transglutaminase_N. DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1. DR PANTHER; PTHR11590:SF38; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 5; 1. DR Pfam; PF00927; Transglut_C; 2. DR Pfam; PF01841; Transglut_core; 1. DR Pfam; PF00868; Transglut_N; 1. DR PIRSF; PIRSF000459; TGM_EBP42; 1. DR SMART; SM00460; TGc; 1. DR SUPFAM; SSF54001; Cysteine proteinases; 1. DR SUPFAM; SSF81296; E set domains; 1. DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2. DR PROSITE; PS00547; TRANSGLUTAMINASES; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000001595}. FT DOMAIN 270..363 FT /note="Transglutaminase-like" FT /evidence="ECO:0000259|SMART:SM00460" FT REGION 470..499 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 477..499 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 278 FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1" FT ACT_SITE 337 FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1" FT ACT_SITE 360 FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1" FT BINDING 400 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2" FT BINDING 402 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2" FT BINDING 448 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2" FT BINDING 453 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2" SQ SEQUENCE 720 AA; 80948 MW; EF709B08A8FFE719 CRC64; MAQGLEVALT DLQSSRNNVR HHTEEIAVDH LLVRRGQAFN LTLYFRNRGF QPGLDNIIFV VETGPLPDLA LGTRAVFSLA RHHSPSPWIA WLETNEATST EVSLCAPPTA AVGRYLLKIH IDSFQGSVTA YQLGEFILLF NPWCPEDAVY LDSEPQRQEY VMNDYGFIYQ GSKNWIRPCP WNYGQFEEKI IDICLKLLDK SLHFQTDSAT DCALRGSPVY ISRVVCAMIN SNDDNGVLNG NWSENYTDGA NPAEWTGSVA ILKQWYATGC QPVRYGQCWV FAAVMCTVMR CLGIPTRVIT NFDSGHDTDG NLIIDEYYDN TGRILGNKKK DTIWNFHVWN ECWMARKDLP PGYGGWQVLD ATPQEMSNGV YCCGPASVRA VKEGEVDLNY DTPFVFSMVN ADCMSWLVQG GKEQKLHQDT SSVGNFISTK SIQSDERDDI TENYKYEEGS LQERQVFLKA LQKLKARRFH GSQRGAELQP SRPTPLSQDS PRSLHTPSLR PSDVVQVSLK FKLLDPPNMG QDICFVLLAL NMSSQFKDLK VNLSAQSLLH DGSPLSPFWQ DIAFITLSPK EAKTYPCKIS YSQYSQYLST DKLIRISALG EEKSSPEKIL VNKIITLSYP SITINVLGAA VVNQPLSIQV IFSNPLSEQV EDCVLTVEGS GLFKKQQKVF LGVLKPQHRA SIILETVPFK SGQRQIQANM RSNKFKDIKG YRNVYVDFAL //