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H2NKW2

- H2NKW2_PONAB

UniProt

H2NKW2 - H2NKW2_PONAB

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Protein
Submitted name:

Uncharacterized protein

Gene

TGM1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei378 – 3781UniRule annotation
Active sitei437 – 4371UniRule annotation
Active sitei460 – 4601UniRule annotation
Metal bindingi500 – 5001CalciumUniRule annotation
Metal bindingi502 – 5021CalciumUniRule annotation
Metal bindingi549 – 5491CalciumUniRule annotation
Metal bindingi554 – 5541CalciumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. keratinocyte differentiation Source: Ensembl
  2. organ morphogenesis Source: Ensembl
  3. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TGM1Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. intrinsic component of membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119108.
InParanoidiH2NKW2.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2NKW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDRRSRRGGG GRSFWARCCG
60 70 80 90 100
CCSCRNAADD DWGPEPSDSR GRGSSSGTRR PGSRGSDSRR PVSRGSGVNA
110 120 130 140 150
AGDGTIQEGM LVVNGVDLLS SRSDQNRREH HTDEYEYDEL IVRRGQPFHM
160 170 180 190 200
LLLLSRTYES SDRITLELLI GNNPEVGKGT HVIIPVGKGG SGGWKAQVVK
210 220 230 240 250
ASGQNLNLRV HTSPNAIIGK FQFTVRTQSD AGEFQLPFDP RNEIYILFNP
260 270 280 290 300
WCPEDIVYVD HEDWRQEYVL NESGRIYYGT EAQIGERTWN YGQFDHGVLD
310 320 330 340 350
ACLYILDRRG MPYGGRGDPV SVSRVISAMV NSLDDNGVLI GNWSGDYSRG
360 370 380 390 400
TNPSAWVGSV EILLSYLRTG YSVPYGQCWV FAGVTTTVLR CLGLATRTVT
410 420 430 440 450
NFNSAHDTDT SLTMDIYFDE NMKPLEHLNH DSVWNFHVWN DCWMKRPDLP
460 470 480 490 500
SGFDGWQVVD ATPQETSSGI FCCGPCSVES IKNGLVYMKY DTPFIFAEVN
510 520 530 540 550
SDKVYWQRQD DGSFKIVYVE EKAIGTLIVT KAIGSNMRED ITYLYKHPEG
560 570 580 590 600
SDAERKAVET AAAHGSKPNV YANRGSAEDV AMQVEAQDAV MGQDLMVSVM
610 620 630 640 650
LTNHSSSRRT VKLHLYLSVT FYTGVSGTIF KETKKEVELA PGASDRVTMP
660 670 680 690 700
VAYEEYRPHL VDQGAMLLNV SGHVKESGQV LAKQHTFRLR TPDLSLTLLG
710 720 730 740 750
AAVVGQECEV QIVFKNPLPV TLTNVVFRLE GSGLQRPKIL NVGDIGGNET
760 770 780 790 800
VTLRQTFVPV RPGPRQLIAS LDSPQLSQVH GVIQVDVAPA PRDGGFFSDA
810
GGDSHLGETI PMASRGGA
Length:818
Mass (Da):89,960
Last modified:March 21, 2012 - v1
Checksum:iC1972B6948EAD967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01219945 Genomic DNA. No translation available.
ABGA01219946 Genomic DNA. No translation available.
RefSeqiXP_002824650.1. XM_002824604.2.

Genome annotation databases

EnsembliENSPPYT00000006732; ENSPPYP00000006477; ENSPPYG00000005695.
GeneIDi100457869.
KEGGipon:100457869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01219945 Genomic DNA. No translation available.
ABGA01219946 Genomic DNA. No translation available.
RefSeqi XP_002824650.1. XM_002824604.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000006732 ; ENSPPYP00000006477 ; ENSPPYG00000005695 .
GeneIDi 100457869.
KEGGi pon:100457869.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

GeneTreei ENSGT00760000119108.
InParanoidi H2NKW2.
KOi K05619.
OMAi GRWGGNP.
OrthoDBi EOG7WT40M.
TreeFami TF324278.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2NKW2_PONAB
AccessioniPrimary (citable) accession number: H2NKW2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3