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H2NKW2

- H2NKW2_PONAB

UniProt

H2NKW2 - H2NKW2_PONAB

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Protein
Submitted name: Uncharacterized protein
Gene
TGM1
Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cofactori

Binds 1 calcium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei378 – 3781 By similarityUniRule annotation
Active sitei437 – 4371 By similarityUniRule annotation
Active sitei460 – 4601 By similarityUniRule annotation
Metal bindingi500 – 5001Calcium By similarityUniRule annotation
Metal bindingi502 – 5021Calcium By similarityUniRule annotation
Metal bindingi549 – 5491Calcium By similarityUniRule annotation
Metal bindingi554 – 5541Calcium By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. keratinocyte differentiation Source: Ensembl
  2. organ morphogenesis Source: Ensembl
  3. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TGM1Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
ProteomesiUP000001595: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: Ensembl
  2. intrinsic component of membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00740000115156.
KOiK05619.
OMAiGRWGGNP.
OrthoDBiEOG7WT40M.
TreeFamiTF324278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2NKW2-1 [UniParc]FASTAAdd to Basket

« Hide

MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDRRSRRGGG GRSFWARCCG    50
CCSCRNAADD DWGPEPSDSR GRGSSSGTRR PGSRGSDSRR PVSRGSGVNA 100
AGDGTIQEGM LVVNGVDLLS SRSDQNRREH HTDEYEYDEL IVRRGQPFHM 150
LLLLSRTYES SDRITLELLI GNNPEVGKGT HVIIPVGKGG SGGWKAQVVK 200
ASGQNLNLRV HTSPNAIIGK FQFTVRTQSD AGEFQLPFDP RNEIYILFNP 250
WCPEDIVYVD HEDWRQEYVL NESGRIYYGT EAQIGERTWN YGQFDHGVLD 300
ACLYILDRRG MPYGGRGDPV SVSRVISAMV NSLDDNGVLI GNWSGDYSRG 350
TNPSAWVGSV EILLSYLRTG YSVPYGQCWV FAGVTTTVLR CLGLATRTVT 400
NFNSAHDTDT SLTMDIYFDE NMKPLEHLNH DSVWNFHVWN DCWMKRPDLP 450
SGFDGWQVVD ATPQETSSGI FCCGPCSVES IKNGLVYMKY DTPFIFAEVN 500
SDKVYWQRQD DGSFKIVYVE EKAIGTLIVT KAIGSNMRED ITYLYKHPEG 550
SDAERKAVET AAAHGSKPNV YANRGSAEDV AMQVEAQDAV MGQDLMVSVM 600
LTNHSSSRRT VKLHLYLSVT FYTGVSGTIF KETKKEVELA PGASDRVTMP 650
VAYEEYRPHL VDQGAMLLNV SGHVKESGQV LAKQHTFRLR TPDLSLTLLG 700
AAVVGQECEV QIVFKNPLPV TLTNVVFRLE GSGLQRPKIL NVGDIGGNET 750
VTLRQTFVPV RPGPRQLIAS LDSPQLSQVH GVIQVDVAPA PRDGGFFSDA 800
GGDSHLGETI PMASRGGA 818
Length:818
Mass (Da):89,960
Last modified:March 21, 2012 - v1
Checksum:iC1972B6948EAD967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01219945 Genomic DNA. No translation available.
ABGA01219946 Genomic DNA. No translation available.
RefSeqiXP_002824650.1. XM_002824604.2.

Genome annotation databases

EnsembliENSPPYT00000006732; ENSPPYP00000006477; ENSPPYG00000005695.
GeneIDi100457869.
KEGGipon:100457869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABGA01219945 Genomic DNA. No translation available.
ABGA01219946 Genomic DNA. No translation available.
RefSeqi XP_002824650.1. XM_002824604.2.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPPYT00000006732 ; ENSPPYP00000006477 ; ENSPPYG00000005695 .
GeneIDi 100457869.
KEGGi pon:100457869.

Organism-specific databases

CTDi 7051.

Phylogenomic databases

GeneTreei ENSGT00740000115156.
KOi K05619.
OMAi GRWGGNP.
OrthoDBi EOG7WT40M.
TreeFami TF324278.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome."
    Wilson R.K., Mardis E.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH2NKW2_PONAB
AccessioniPrimary (citable) accession number: H2NKW2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi