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Protein
Submitted name:

Dopamine receptor D2

Gene

DRD2

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Dopamine receptor D2Imported
Gene namesi
Name:DRD2Imported
OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
Taxonomic identifieri9601 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
Proteomesi
  • UP000001595 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 77HelicalSequence analysisAdd BLAST24
Transmembranei89 – 111HelicalSequence analysisAdd BLAST23
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei210 – 234HelicalSequence analysisAdd BLAST25
Transmembranei392 – 413HelicalSequence analysisAdd BLAST22
Transmembranei425 – 447HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000004451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 444G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST376

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139331.
InParanoidiH2NFB8.
KOiK04145.
OMAiRNWSRPF.
OrthoDBiEOG091G06VI.
TreeFamiTF334382.

Family and domain databases

InterProiView protein in InterPro
IPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H2NFB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPFFLARAW PPSGSTAPMD PLNLSWYDDD LERQNWSRPF NGSDGKADRP
60 70 80 90 100
HYNYYATLLT LLIAVIVFGN VLVCMAVSRE KALQTTTNYL IVSLAVADLL
110 120 130 140 150
VATLVMPWVV YLEVVGEWKF SRIHCDIFVT LDVMMCTASI LNLCAISIDR
160 170 180 190 200
YTAVAMPMLY NTRYSSKRRV TVMISIVWVL SFTISCPLLF GLNNTDQNEC
210 220 230 240 250
IIANPAFVVY SSIVSFYVPF IVTLLVYIKI YIVLRRRRKR VNTKRSSRAF
260 270 280 290 300
RAHLRAPLKG NCTHPEDMKL CTVIMKSNGS FPVNRRRVEA ARRAQELEME
310 320 330 340 350
MLSSTSPPER TRYSPIPPSH HQLTLPDPSH HGLHSTPDSP AKPEKNGHAK
360 370 380 390 400
DHPKIAKIFE IQTMPNGKTR TSLKTMSRRK LSQQKEKKAT QMLAIVLGVF
410 420 430 440 450
IICWLPFFIT HILNIHCDCN IPPVLYSAFT WLGYVNSAVN PIIYTTFNIE
460
FRKAFLKILH C
Length:461
Mass (Da):52,568
Last modified:January 9, 2013 - v2
Checksum:iF9E84F0626917AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01268948 Genomic DNA. No translation available.
RefSeqiXP_009245349.1. XM_009247074.1.

Genome annotation databases

EnsembliENSPPYT00000004626; ENSPPYP00000004451; ENSPPYG00000003885.
GeneIDi100442948.
KEGGipon:100442948.

Similar proteinsi

Entry informationi

Entry nameiH2NFB8_PONAB
AccessioniPrimary (citable) accession number: H2NFB8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: October 25, 2017
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported