H2NEQ1 (H2NEQ1_PONAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein Wnt RuleBase RU003500

Gene names

Name:

WNT11 Ensembl ENSPPYP00000004224

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome] Ensembl ENSPPYP00000004224

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors By similarity. RuleBase RU003500
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity RuleBase RU003500.
Sequence similarities	Belongs to the Wnt family. RuleBase RU003500
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSPPYP00000004224

Ontologies

Keywords
Biological process	Wnt signaling pathway RuleBase RU003500 SAAS SAAS005817
Cellular component	Extracellular matrix SAAS SAAS005817 Secreted
Molecular function	Developmental protein SAAS SAAS005817 RuleBase RU003500
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from electronic annotation. Source: Compara artery morphogenesis Inferred from electronic annotation. Source: Compara bone mineralization Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cloacal septation Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara lung-associated mesenchyme development Inferred from electronic annotation. Source: Compara mesonephric duct development Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of fibroblast growth factor production Inferred from electronic annotation. Source: Compara negative regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara neuroendocrine cell differentiation Inferred from electronic annotation. Source: Compara non-canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of protein kinase C signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara positive regulation of transforming growth factor beta2 production Inferred from electronic annotation. Source: Compara protein localization to cell surface Inferred from electronic annotation. Source: Compara protein phosphorylation Inferred from electronic annotation. Source: Compara tight junction assembly Inferred from electronic annotation. Source: Compara ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	Ras GTPase activator activity Inferred from electronic annotation. Source: Compara protein kinase activator activity Inferred from electronic annotation. Source: Compara transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	H2NEQ1 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 0E29717C98541DBB	FASTA	354	39,179
	10 20 30 40 50 60 MRARPQVCEA LLFALALQTG VCYGIKWLAL SKTPSALALN QTQHCKQLEG LVSAQVQLCR 70 80 90 100 110 120 SNLELMHTVV HAAREVMKAC RRAFADMRWN CSSIELAPNY LLDLERGTRE SAFVYALSAA 130 140 150 160 170 180 AISHAIARAC TSGDLPGCSC GPVPGEPPGP GNRWGGCADN LSYGLLMGAK FSDAPMKVKK 190 200 210 220 230 240 TGSQANKLMR LHNSEVGRQA LRASLEMKCK CHGVSGSCSI RTCWKGLQEL QDVAADLKTR 250 260 270 280 290 300 YLSATKVVHR PMGTRKHLVP KDLDIRPVKD SELVYLQSSP DFCMKNEKVG SHGTQDRQCN 310 320 330 340 350 KTSNGSDSCD LMCCGRGYNP YTDRVVERCH CKYHWCCYVT CRRCERTVER YVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome." Wilson R.K., Mardis E. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABGA01329541 Genomic DNA. No translation available. ABGA01329542 Genomic DNA. No translation available. ABGA01329543 Genomic DNA. No translation available. ABGA01329544 Genomic DNA. No translation available. ABGA01329545 Genomic DNA. No translation available.
RefSeq	XP_002822307.1. XM_002822261.1.
3D structure databases
ProteinModelPortal	H2NEQ1.
ModBase	Search...
Proteomic databases
PRIDE	H2NEQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000004396; ENSPPYP00000004224; ENSPPYG00000003696.
GeneID	100443554.
KEGG	pon:100443554.
Organism-specific databases
CTD	7481.
Phylogenomic databases
GeneTree	ENSGT00700000104317.
KO	K01384.
OMA	ELIYLQS.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026536. Wnt-11. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF7. PTHR12027:SF7. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2NEQ1_PONAB

Accession

Primary (citable) accession number: H2NEQ1

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	March 6, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)