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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 2

Gene

pcsk2

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 2Imported
Gene namesi
Name:pcsk2Imported
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Chromosome 15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500356523027 – 641Sequence analysisAdd BLAST615

Structurei

3D structure databases

ProteinModelPortaliH2LPZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini463 – 599P/Homo BInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili611 – 631Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
KOG3526 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

H2LPZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGSPRHGTA VGVLVLLNAL LFATEAAEGV LTEHLLVQLH EDAQDEAHQL
60 70 80 90 100
AAQHGFQSAR KLPFGDGLFH FYPQDTSKRR SKRSARIKQW LQNNRRVKNV
110 120 130 140 150
IEQEGFRRQK RGYRNINDIE VNMSDPLFTK QWYLINTGQA DGTPGLDLNV
160 170 180 190 200
AEAWQLGYTG KGVTIAIMDD GIDYLHPDLA SNYNADASYD FSSNDPFPFP
210 220 230 240 250
RYTDDWFNSH GTRCAGEVSA AANNNICGVG VAYNSKVAGI RMLDQPFMTD
260 270 280 290 300
IIEASSISHM PQTIDIYSAS WGPTDDGKTV DGPRELTLQA MADGVNKGRG
310 320 330 340 350
GKGSIYVWAS GDGGSYDDCN CDGYASSMWT ISINSAINDG RTALYDESCS
360 370 380 390 400
STLASTFSNG RKRNPEAGVA TTDLYGNCTL RHSGTSAAAP EAAGVFALAL
410 420 430 440 450
EANPNLTWRD MQHLSVLTSK RNQLHDEVHQ WRRNGVGLEF NHLFGYGVLD
460 470 480 490 500
AGGMVKMAKE WKTVPERFHC VAGSIQEPHK IQSGNKLVLA INTEACEGKD
510 520 530 540 550
NFVRYLEHVQ AVVTVNATRR GDLNINMTSP MGTKSLLLSR RPRDDDSKVG
560 570 580 590 600
FDKWPFMTTH TWGEDPRGTW VLEVGFQGDQ PQRGVLKEWT VMLHGTQSAP
610 620 630 640
YIDQIVRDYQ SKLAMSKKEE LEEELDEAVE RSLKSLLSKN N
Length:641
Mass (Da):70,978
Last modified:March 21, 2012 - v1
Checksum:i6799ACA95A63639F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAAF04050100 Genomic DNA No translation available.
BAAF04050101 Genomic DNA No translation available.
RefSeqiXP_011482715.1, XM_011484413.1
UniGeneiOla.4111

Genome annotation databases

EnsembliENSORLT00000008128; ENSORLP00000008127; ENSORLG00000006472
GeneIDi100049241

Similar proteinsi

Entry informationi

Entry nameiH2LPZ1_ORYLA
AccessioniPrimary (citable) accession number: H2LPZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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