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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDHB (1 of many)

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB (1 of many)), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (LOC101169635), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (LOC101169635), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB (1 of many))
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDHB (1 of many)Imported
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500356445717 – 280Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSequence analysisAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000000328.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 1312Fe-2S ferredoxin-typeInterPro annotationAdd BLAST92
Domaini174 – 2044Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3049. Eukaryota.
COG0479. LUCA.
GeneTreeiENSGT00390000013558.
OMAiESWIHTN.
OrthoDBiEOG091G0EKC.
TreeFamiTF300754.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.1060.10. 1 hit.
3.10.20.30. 1 hit.
InterProiView protein in InterPro
IPR036010. 2Fe-2S_ferredoxin-like_sf.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom_sf.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
PfamiView protein in Pfam
PF13085. Fer2_3. 1 hit.
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiView protein in PROSITE
PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H2L3K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVLLSRNL LAFTNGGTMV MVRSTQTVAA AAPEPRMKAF QVYRWDPDRP
60 70 80 90 100
GDKPRMQTYE VDLNTCGPMV LDALIKIKNE MDPTLTFRRS CREGICGSCA
110 120 130 140 150
MNINGENTLA CLNRINANSS KATKIYPLPH MYVVKDLVPD MSNFYAQYKS
160 170 180 190 200
IEPYLKKKDG SQEGKTQYFQ SVEDRQKLDG LYECILCACC STSCPSYWWN
210 220 230 240 250
GDKYLGPAVL MQAYRWMIDS RDEFTEERLS KLQDPFSLYR CHTIMNCTKT
260 270 280
CPKGLNPGKA IAEIKKMMAT YREKTTAAAS
Length:280
Mass (Da):31,748
Last modified:March 21, 2012 - v1
Checksum:iB10E2600616680BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAAF04043223 Genomic DNA. No translation available.
BAAF04043224 Genomic DNA. No translation available.
BAAF04043225 Genomic DNA. No translation available.
BAAF04043226 Genomic DNA. No translation available.
RefSeqiXP_004070269.1. XM_004070221.2.

Genome annotation databases

EnsembliENSORLT00000000328; ENSORLP00000000328; ENSORLG00000000267.
GeneIDi101170091.

Similar proteinsi

Entry informationi

Entry nameiH2L3K4_ORYLA
AccessioniPrimary (citable) accession number: H2L3K4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: December 20, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported