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Protein

Parkeol synthase

Gene

Os11g0189600

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically mediates the conversion of oxidosqualene ((3S)-2,3-epoxy-2,3-dihydrosqualene) to parkeol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = parkeol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei483Proton donorSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17969.
ReactomeiR-OSA-191273. Cholesterol biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Parkeol synthase (EC:5.4.99.47)
Gene namesi
Ordered Locus Names:Os11g0189600, LOC_Os11g08569
ORF Names:OsJ_33246
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004189651 – 759Parkeol synthaseAdd BLAST759

Proteomic databases

PaxDbiH2KWF1.

Expressioni

Gene expression databases

ExpressionAtlasiH2KWF1. baseline and differential.
GenevisibleiH2KWF1. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os11g08569.1.

Structurei

3D structure databases

SMRiH2KWF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati147 – 188PFTB 1Add BLAST42
Repeati512 – 557PFTB 2Add BLAST46
Repeati589 – 629PFTB 3Add BLAST41
Repeati638 – 689PFTB 4Add BLAST52

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0497. Eukaryota.
COG1657. LUCA.
HOGENOMiHOG000234317.
InParanoidiH2KWF1.
KOiK19010.
OMAiCNLQAHD.
OrthoDBiEOG0936031Q.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
InterProiView protein in InterPro
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
PfamiView protein in Pfam
PF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiView protein in PROSITE
PS01074. TERPENE_SYNTHASES. 1 hit.

Sequencei

Sequence statusi: Complete.

H2KWF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLKVSEGG SPWLRSVNNL LGRQVWEFDP DLGTPEERAD VEKARREFAE
60 70 80 90 100
HRFERKHSSD LLMRMQFAKE NCQKLDLLAV KRGEHEDVMG EAVWSSLKRA
110 120 130 140 150
ISRVCNLQAH DGHWPGDYAG LMFFLPGLII TLHVSGVLNT VLSSEHQKEM
160 170 180 190 200
RRYIYNHQNE DGGWGLHIEG HSTMLGSSLN YVALRLLGEG PNGGDGCIEN
210 220 230 240 250
GRNWILDHGG ATFTTSWGKF WLSVLGVFDW SGNNPVPPEL LLLPYQLPFH
260 270 280 290 300
PGRMSSYIRM VFIPMSYIYG KRFVGPVTPV VLELRSELYN DPYDEIDWNK
310 320 330 340 350
ARTQCAKEDM YYPRSSKLDM FWSFLHKFIE PVLLRWPGRK LREKALATSM
360 370 380 390 400
RNVHYEDECT RYICFGGVPK ALNILACWIE DPSSEAFKCH IARVYDYLWI
410 420 430 440 450
AEDGMKMQIY DGSQVWDAGL TVEALVATDL VKELGPTLKR AHSFLKNSQL
460 470 480 490 500
LDNCPRDFNR WYRHISKGGW TFTTADDGWQ VSDCTATALK ACLLLSRISP
510 520 530 540 550
EIVGEPLEID AQYDAVNCLM SLMNDNGGFS AFELVRSNTW LEHINPTEAF
560 570 580 590 600
GRVMIEYPYV ECTSSSIQCL ALFKKLHPGH RKEEVENCIS KGANFIESSQ
610 620 630 640 650
RSDGSWYGSW GICFTYATWF AVTGLVSAGR TLGNSATVRK ACDFLLSKQL
660 670 680 690 700
PSGGWGESYL SCHDEVYTNL KGNRPHGTHT AWAMIALIDA GQAERDPVPL
710 720 730 740 750
HRAAKALLNL QLEDGEFPQQ EIVGVFLQTA MISYSQYRNI FPIMALTGYR

RRVLLAGNI
Length:759
Mass (Da):86,127
Last modified:March 21, 2012 - v1
Checksum:i98EFB2E0088C5675
GO

Sequence cautioni

The sequence AAX95229 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated
The sequence AAX95231 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated
The sequence ABG22398 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAG89914 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAH95124 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAZ17703 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134046 Genomic DNA. Translation: AAX95229.1. Sequence problems.
AC134046 Genomic DNA. Translation: AAX95231.1. Sequence problems.
DP000010 Genomic DNA. Translation: ABG22398.1. Sequence problems.
DP000010 Genomic DNA. Translation: ABG22399.1.
AP008217 Genomic DNA. Translation: BAH95124.1. Sequence problems.
AP014967 Genomic DNA. Translation: BAT13009.1.
CM000148 Genomic DNA. Translation: EAZ17703.1. Sequence problems.
AK066327 mRNA. Translation: BAG89914.1. Different initiation.
RefSeqiXP_015617632.1. XM_015762146.1.
XP_015617633.1. XM_015762147.1.
UniGeneiOs.87784.

Genome annotation databases

EnsemblPlantsiOS11T0189600-01; OS11T0189600-01; OS11G0189600.
GeneIDi9268610.
GrameneiOS11T0189600-01; OS11T0189600-01; OS11G0189600.
KEGGiosa:9268610.

Similar proteinsi

Entry informationi

Entry nameiPAKSY_ORYSJ
AccessioniPrimary (citable) accession number: H2KWF1
Secondary accession number(s): A0A0P0XZQ3
, B7EC17, C7J910, Q53NJ6, Q53NK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: March 21, 2012
Last modified: August 30, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families