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H2KWF1

- PAKSY_ORYSJ

UniProt

H2KWF1 - PAKSY_ORYSJ

Protein

Parkeol synthase

Gene

Os11g0189600

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Specifically mediates the conversion of oxidosqualene ((3S)-2,3-epoxy-2,3-dihydrosqualene) to parkeol.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = parkeol.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei483 – 4831Proton donorSequence Analysis

    GO - Molecular functioni

    1. intramolecular transferase activity Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17969.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parkeol synthase (EC:5.4.99.47)
    Gene namesi
    Ordered Locus Names:Os11g0189600, LOC_Os11g08569
    ORF Names:OsJ_33246
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Parkeol synthasePRO_0000418965Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os11g08569.1.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati147 – 18842PFTB 1Add
    BLAST
    Repeati512 – 55746PFTB 2Add
    BLAST
    Repeati589 – 62941PFTB 3Add
    BLAST
    Repeati638 – 68952PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiCHIARVY.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2KWF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRLKVSEGG SPWLRSVNNL LGRQVWEFDP DLGTPEERAD VEKARREFAE    50
    HRFERKHSSD LLMRMQFAKE NCQKLDLLAV KRGEHEDVMG EAVWSSLKRA 100
    ISRVCNLQAH DGHWPGDYAG LMFFLPGLII TLHVSGVLNT VLSSEHQKEM 150
    RRYIYNHQNE DGGWGLHIEG HSTMLGSSLN YVALRLLGEG PNGGDGCIEN 200
    GRNWILDHGG ATFTTSWGKF WLSVLGVFDW SGNNPVPPEL LLLPYQLPFH 250
    PGRMSSYIRM VFIPMSYIYG KRFVGPVTPV VLELRSELYN DPYDEIDWNK 300
    ARTQCAKEDM YYPRSSKLDM FWSFLHKFIE PVLLRWPGRK LREKALATSM 350
    RNVHYEDECT RYICFGGVPK ALNILACWIE DPSSEAFKCH IARVYDYLWI 400
    AEDGMKMQIY DGSQVWDAGL TVEALVATDL VKELGPTLKR AHSFLKNSQL 450
    LDNCPRDFNR WYRHISKGGW TFTTADDGWQ VSDCTATALK ACLLLSRISP 500
    EIVGEPLEID AQYDAVNCLM SLMNDNGGFS AFELVRSNTW LEHINPTEAF 550
    GRVMIEYPYV ECTSSSIQCL ALFKKLHPGH RKEEVENCIS KGANFIESSQ 600
    RSDGSWYGSW GICFTYATWF AVTGLVSAGR TLGNSATVRK ACDFLLSKQL 650
    PSGGWGESYL SCHDEVYTNL KGNRPHGTHT AWAMIALIDA GQAERDPVPL 700
    HRAAKALLNL QLEDGEFPQQ EIVGVFLQTA MISYSQYRNI FPIMALTGYR 750
    RRVLLAGNI 759
    Length:759
    Mass (Da):86,127
    Last modified:March 21, 2012 - v1
    Checksum:i98EFB2E0088C5675
    GO

    Sequence cautioni

    The sequence BAG89914.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAX95229.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.
    The sequence AAX95231.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.
    The sequence ABG22398.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence BAH95124.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAZ17703.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134046 Genomic DNA. Translation: AAX95229.1. Sequence problems.
    AC134046 Genomic DNA. Translation: AAX95231.1. Sequence problems.
    DP000010 Genomic DNA. Translation: ABG22399.1.
    DP000010 Genomic DNA. Translation: ABG22398.1. Sequence problems.
    AP008217 Genomic DNA. Translation: BAH95124.1. Sequence problems.
    CM000148 Genomic DNA. Translation: EAZ17703.1. Sequence problems.
    AK066327 mRNA. Translation: BAG89914.1. Different initiation.
    RefSeqiNP_001176396.1. NM_001189467.1.
    UniGeneiOs.87784.

    Genome annotation databases

    EnsemblPlantsiOS11T0189600-01; OS11T0189600-01; OS11G0189600.
    GeneIDi9268610.
    KEGGiosa:9268610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134046 Genomic DNA. Translation: AAX95229.1 . Sequence problems.
    AC134046 Genomic DNA. Translation: AAX95231.1 . Sequence problems.
    DP000010 Genomic DNA. Translation: ABG22399.1 .
    DP000010 Genomic DNA. Translation: ABG22398.1 . Sequence problems.
    AP008217 Genomic DNA. Translation: BAH95124.1 . Sequence problems.
    CM000148 Genomic DNA. Translation: EAZ17703.1 . Sequence problems.
    AK066327 mRNA. Translation: BAG89914.1 . Different initiation.
    RefSeqi NP_001176396.1. NM_001189467.1.
    UniGenei Os.87784.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os11g08569.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS11T0189600-01 ; OS11T0189600-01 ; OS11G0189600 .
    GeneIDi 9268610.
    KEGGi osa:9268610.

    Phylogenomic databases

    OMAi CHIARVY.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17969.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
      The rice chromosomes 11 and 12 sequencing consortia
      BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    6. "Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases."
      Ito R., Mori K., Hashimoto I., Nakano C., Sato T., Hoshino T.
      Org. Lett. 13:2678-2681(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiPAKSY_ORYSJ
    AccessioniPrimary (citable) accession number: H2KWF1
    Secondary accession number(s): B7EC17
    , C7J910, Q53NJ6, Q53NK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3