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H2K945

- H2K945_STRHJ

UniProt

H2K945 - H2K945_STRHJ

Protein

Kynureninase

Gene

kynU

Organism
Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei107 – 1071Pyridoxal phosphateUniRule annotation
    Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
    Binding sitei207 – 2071Pyridoxal phosphateUniRule annotation
    Binding sitei229 – 2291Pyridoxal phosphateUniRule annotation
    Binding sitei259 – 2591Pyridoxal phosphateUniRule annotation
    Binding sitei285 – 2851Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciSHYG1133850:GLLU-5437-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:SHJG_5391Imported
    OrganismiStreptomyces hygroscopicus subsp. jinggangensis (strain 5008)Imported
    Taxonomic identifieri1133850 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000007170: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1384Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H2K945-1 [UniParc]FASTAAdd to Basket

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    MSELPLLAKE LDQADELAPL RDRFVLDSAS GDAAGPAGVY LDGNSLGALP    50
    AHVPDRVADV VRRQWGELRI RSWEESGWWT APERIGDRIA PLVGAAPGQI 100
    VVGDSTSVNV FKALVAAIRM ADAGRDEILV DATTFPTDGY IAESAARLTG 150
    RTLRAVTPAE VPAALGDRTA AVLLNHVDYR TGRLHDLPAL TAAVHACGAL 200
    AVWDLCHSAG ALPVGLDEHG VDLAVGCTYK YLNGGPGSPA YLYVRRELQD 250
    RFDSPLPGWN SHAEPFGMSP SYAPAAGAVR GRVGTPDILS LLALEAALDV 300
    WDGVSVDAVR AKSLALTDFF LRCVDEYTEP GRVECVTPGP HAERGSQIAL 350
    RCPDAGEVMK RLIARGVVGD FRHPDILRFG FTPLYVSFRD AERAARTLGE 400
    ELA 403
    Length:403
    Mass (Da):43,016
    Last modified:March 21, 2012 - v1
    Checksum:i042DCE3677FACBE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003275 Genomic DNA. Translation: AEY90659.1.
    RefSeqiYP_006246532.1. NC_017765.1.

    Genome annotation databases

    EnsemblBacteriaiAEY90659; AEY90659; SHJG_5391.
    GeneIDi12810804.
    KEGGishy:SHJG_5391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003275 Genomic DNA. Translation: AEY90659.1 .
    RefSeqi YP_006246532.1. NC_017765.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEY90659 ; AEY90659 ; SHJG_5391 .
    GeneIDi 12810804.
    KEGGi shy:SHJG_5391.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci SHYG1133850:GLLU-5437-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Streptomyces hygroscopicus subsp. jinggangensis 5008."
      Wu H., Bai L.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 5008Imported.

    Entry informationi

    Entry nameiH2K945_STRHJ
    AccessioniPrimary (citable) accession number: H2K945
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3