Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

H2K393 (H2K393_STRHJ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2101N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2081ATP By similarity HAMAP-Rule MF_00407
Binding site2151ATP By similarity HAMAP-Rule MF_00407
Binding site2301ATP By similarity HAMAP-Rule MF_00407
Binding site2591ATP By similarity HAMAP-Rule MF_00407
Binding site2991ATP By similarity HAMAP-Rule MF_00407
Binding site3741ATP By similarity HAMAP-Rule MF_00407
Binding site3801ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
H2K393 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: DBD10EE3DAB5F1B9

FASTA51255,043
        10         20         30         40         50         60 
MLLTRLAQVS REVAATAARS RKIALLAELF RDAEADDVPI VIPYLAGRLP QGRLGVGWKV 

        70         80         90        100        110        120 
LGRPVPPAAE PSLTVREVDA RLTGLGKVSG PGSQAERTRI VGELMGAATE EEQRFLLGLL 

       130        140        150        160        170        180 
TGEVRQGALD AVAVEGLARA TGADPADVRR AVMLAGSLQT VAQALLGEGP GSLDRFRLTV 

       190        200        210        220        230        240 
GRPVLPMLAH SASSVAEAVE KLGACAVEEK LDGIRVQVHR DGDTVRIHTR TLDDITGRLP 

       250        260        270        280        290        300 
EVTSAALELG GERFILDGEV ISFDAAGRPR SFQETAGRVG SRTDVARAAG QTPVSPVFFD 

       310        320        330        340        350        360 
ALSVDGRDLL DLPFAERHAE LARLVPEPMR VRRTVASGPE DIPEAERFLA DTLARGHEGV 

       370        380        390        400        410        420 
VVKALDAPYS AGRRGAAWLK VKPVHTLDLV VLAAEWGHGR RTGKLSNLHL GARTPDGGFA 

       430        440        450        460        470        480 
MLGKTFKGMT DAMLAWQTER LKELAVEDNG WVVRVRPELV VEIAYDGLQR STRYPAGVTL 

       490        500        510 
RFARVVRYRE DKRPEEADTV EALLAAHPEV SP 

« Hide

References

[1]"Genomic analysis of Streptomyces hygroscopicus subsp. jinggangensis 5008."
Wu H., Bai L.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5008.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003275 Genomic DNA. Translation: AEY87915.1.
RefSeqYP_006243788.1. NC_017765.1.

3D structure databases

ProteinModelPortalH2K393.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEY87915; AEY87915; SHJG_2641.
GeneID12806376.
KEGGshy:SHJG_2641.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.

Enzyme and pathway databases

BioCycSHYG1133850:GLLU-2634-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2K393_STRHJ
AccessionPrimary (citable) accession number: H2K393
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)