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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
Binding sitei215 – 2151ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation
Binding sitei259 – 2591ATPUniRule annotation
Binding sitei299 – 2991ATPUniRule annotation
Binding sitei374 – 3741ATPUniRule annotation
Binding sitei380 – 3801ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHYG1133850:GLLU-2634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:SHJG_2641Imported
OrganismiStreptomyces hygroscopicus subsp. jinggangensis (strain 5008)Imported
Taxonomic identifieri1133850 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000007170 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1133850.SHJG_2641.

Structurei

3D structure databases

ProteinModelPortaliH2K393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2K393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTRLAQVS REVAATAARS RKIALLAELF RDAEADDVPI VIPYLAGRLP
60 70 80 90 100
QGRLGVGWKV LGRPVPPAAE PSLTVREVDA RLTGLGKVSG PGSQAERTRI
110 120 130 140 150
VGELMGAATE EEQRFLLGLL TGEVRQGALD AVAVEGLARA TGADPADVRR
160 170 180 190 200
AVMLAGSLQT VAQALLGEGP GSLDRFRLTV GRPVLPMLAH SASSVAEAVE
210 220 230 240 250
KLGACAVEEK LDGIRVQVHR DGDTVRIHTR TLDDITGRLP EVTSAALELG
260 270 280 290 300
GERFILDGEV ISFDAAGRPR SFQETAGRVG SRTDVARAAG QTPVSPVFFD
310 320 330 340 350
ALSVDGRDLL DLPFAERHAE LARLVPEPMR VRRTVASGPE DIPEAERFLA
360 370 380 390 400
DTLARGHEGV VVKALDAPYS AGRRGAAWLK VKPVHTLDLV VLAAEWGHGR
410 420 430 440 450
RTGKLSNLHL GARTPDGGFA MLGKTFKGMT DAMLAWQTER LKELAVEDNG
460 470 480 490 500
WVVRVRPELV VEIAYDGLQR STRYPAGVTL RFARVVRYRE DKRPEEADTV
510
EALLAAHPEV SP
Length:512
Mass (Da):55,043
Last modified:March 21, 2012 - v1
Checksum:iDBD10EE3DAB5F1B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003275 Genomic DNA. Translation: AEY87915.1.
RefSeqiWP_014671255.1. NC_017765.1.
YP_006243788.1. NC_017765.1.

Genome annotation databases

EnsemblBacteriaiAEY87915; AEY87915; SHJG_2641.
GeneIDi12806376.
KEGGishy:SHJG_2641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003275 Genomic DNA. Translation: AEY87915.1.
RefSeqiWP_014671255.1. NC_017765.1.
YP_006243788.1. NC_017765.1.

3D structure databases

ProteinModelPortaliH2K393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1133850.SHJG_2641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEY87915; AEY87915; SHJG_2641.
GeneIDi12806376.
KEGGishy:SHJG_2641.

Phylogenomic databases

KOiK10747.

Enzyme and pathway databases

BioCyciSHYG1133850:GLLU-2634-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic analysis of Streptomyces hygroscopicus subsp. jinggangensis 5008."
    Wu H., Bai L.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5008Imported.

Entry informationi

Entry nameiH2K393_STRHJ
AccessioniPrimary (citable) accession number: H2K393
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: June 24, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.