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H2I5B7

- H2I5B7_CORDV

UniProt

H2I5B7 - H2I5B7_CORDV

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Protein
Alanine racemase
Gene
alr, CDVA01_0454
Organism
Corynebacterium diphtheriae (strain VA01)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei261 – 2611Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei309 – 3091Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCDIP698971:GHYD-472-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CDVA01_0454Imported
OrganismiCorynebacterium diphtheriae (strain VA01)Imported
Taxonomic identifieri698971 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007155: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH2I5B7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H2I5B7-1 [UniParc]FASTAAdd to Basket

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MNLLETRISC EAIAANTRRL KDMVAPAQLM CVVKADGYNH GAPEVATVMA    50
RNGADQFGVA TLAEAHQLRD AGITLPILCW IWSPEQDFSA AIDRDIDLAA 100
VSMEHVRALI AEAMRRPAGT RVRVTVKIDT ELHRSGIDEA NWTEAFELLH 150
ACPQINVTGV FSHLACADDL ESDYTDHQAE VFRRAIDAGR RVGLDLSVNH 200
LAASPATLTR PDLHFDMVRP GLALYGHEPI AGLDHGLREA MTWIGSVTVV 250
KPIAAGQGTS YNMTWHAPAD GYLCVVPVGY ADGLPRNVQG HLEVTIAGTR 300
YPQVGRVCMD QIVVFLGDNS RGVAPGDEAI IFGPRDTQAM TVTELACATG 350
TINYEILCRP TGRSHRTYSA LDAVAPTHPT ES 382
Length:382
Mass (Da):41,337
Last modified:March 21, 2012 - v1
Checksum:i33AE57F1B1D9235A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003217 Genomic DNA. Translation: AEX82723.1.
RefSeqiWP_014311265.1. NC_016790.1.
YP_005144363.1. NC_016790.1.

Genome annotation databases

EnsemblBacteriaiAEX82723; AEX82723; CDVA01_0454.
GeneIDi11718942.
KEGGicdv:CDVA01_0454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003217 Genomic DNA. Translation: AEX82723.1 .
RefSeqi WP_014311265.1. NC_016790.1.
YP_005144363.1. NC_016790.1.

3D structure databases

ProteinModelPortali H2I5B7.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX82723 ; AEX82723 ; CDVA01_0454 .
GeneIDi 11718942.
KEGGi cdv:CDVA01_0454.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CDIP698971:GHYD-472-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VA01Imported.

Entry informationi

Entry nameiH2I5B7_CORDV
AccessioniPrimary (citable) accession number: H2I5B7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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