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H2HDJ2

- H2HDJ2_CORDJ

UniProt

H2HDJ2 - H2HDJ2_CORDJ

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Protein

Phosphoenolpyruvate carboxylase

Gene
ppc, CDHC02_1032
Organism
Corynebacterium diphtheriae (strain HC02)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei576 – 5761 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciCDIP698968:GI5N-1058-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:CDHC02_1032Imported
OrganismiCorynebacterium diphtheriae (strain HC02)Imported
Taxonomic identifieri698968 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007158: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2HDJ2-1 [UniParc]FASTAAdd to Basket

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MGTLCIHHFC RKAELVTAAI SDRVREDIRL LGRVLGRVIA QQEGEEVYEL    50
VEATRRMAFD VSHGDADPED LMVIFRDLDI TKTNLVARAF SYFALLANLA 100
EDLDDESVEA DVSLRKTFAK LKREGVSAAD AASVIRSAEV APVLTAYPTE 150
TRRRTVFDTQ TRIKQLLKDA HHGGDMQVIE QEMYLRMTLL WQTALIRIAR 200
PTLEDEIDVG LRYYKKSLLE QVPALNRSIR HSMRETFGLQ LPDIAVMRPG 250
SWIGGDHDGN PYVNARTLTY ATRQAAKTVA RYYVEQLGEL ERELSLSDRY 300
SSCSKELLAL AEASGNNWES RVDEPYRRAV YGMRARMKSN VDALERPEKT 350
AGRKSSKRTP YATPDDFLRD LDVIDRSLRA HNDDVIADDR LARIRSAVTT 400
FGFHLYTLDI RQNSESFEAV IEEVFAAARR VPGGKRYSEL AEAEKVELLI 450
QELQTPRPLL FPGALEVEDA FSADTTKELG IFLAAAQAVR DFGSRSIAHC 500
IISMTATVSD ILEPMVLLKE VGLRDVDVVP LFETIDDLRC GAAILRELWS 550
HPFYREHLRA RGDIQEVMLG YSDSNKDGGY LQANWALYDA ELGLVELCRE 600
HNIELRLAHG RGGAVGRGGG PTYDAILAQP KGAVSGSVRI TEQGEVISAK 650
YGAPETARRH LEAFVSGALE ASLLDTEPIA DPDRAYAIMR DLAGFSGQRY 700
QELVGDPGFI EYFTQSTPLH EIGELNLGSR PAARKQTTAI SDLRAIPWVL 750
SWSQSRTNIP GWFGVGSAVS RFVSAVPEKD RESRWQELRD LYATWPFFRS 800
VMSNMAQVMA KAEISLARLY ADLVDDTEVA DRIYALIAEE FVLTRRAYLA 850
ITGNEALVSE NQRQARSLKR RYPYLLPLNA IQLELLRRYR GGDDQFLVSK 900
TIQVTMNGLA TALRNAG 917
Length:917
Mass (Da):102,739
Last modified:March 21, 2012 - v1
Checksum:i22490AD385C3006C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003213 Genomic DNA. Translation: AEX76524.1.
RefSeqiWP_014320066.1. NC_016802.1.
YP_005164815.1. NC_016802.1.

Genome annotation databases

EnsemblBacteriaiAEX76524; AEX76524; CDHC02_1032.
GeneIDi11738964.
KEGGicde:CDHC02_1032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003213 Genomic DNA. Translation: AEX76524.1 .
RefSeqi WP_014320066.1. NC_016802.1.
YP_005164815.1. NC_016802.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX76524 ; AEX76524 ; CDHC02_1032 .
GeneIDi 11738964.
KEGGi cde:CDHC02_1032.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci CDIP698968:GI5N-1058-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HC02Imported.

Entry informationi

Entry nameiH2HDJ2_CORDJ
AccessioniPrimary (citable) accession number: H2HDJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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