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H2H6Q7

- H2H6Q7_CORDH

UniProt

H2H6Q7 - H2H6Q7_CORDH

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, CDHC01_1033
Organism
Corynebacterium diphtheriae (strain HC01)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471 By similarityUniRule annotation
Active sitei576 – 5761 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciCDIP698967:GHQ6-1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:CDHC01_1033Imported
OrganismiCorynebacterium diphtheriae (strain HC01)Imported
Taxonomic identifieri698967 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007157: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H2H6Q7-1 [UniParc]FASTAAdd to Basket

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MGTLCIHHFC RKAELVTAAI SDRVREDIRL LGRVLGRVIA QQEGEEVYEL    50
VEATRRMAFD VSHGDADPED LMVIFRDLDI TKTNLVARAF SYFALLANLV 100
EDLDDESVEA DVSLRKTFAK LKREGVSAAD AASVIRSAEV APVLTAHPTE 150
TRRRTVFDTQ TRIKQLLKDA HHGGDMQVIE QEMYLRMTLL WQTALIRIAR 200
PTLEDEIDVG LRYYKKSLLE QVPALNRSIR HSMRETFGLQ LPDIAVMRPG 250
SWIGGDHDGN PYVNARTLTY ATRQAAKTVA RYYVEQLGEL ERELSLSDRY 300
SSCSKELLAL AEASGNNWES RVDEPYRRAV YGMRARMKSN VDALERPEKT 350
AGKKSSKRTP YATPEEFLRD LDVIDRSLRA HNDDVIADDR LARIRSAVTT 400
FGFHLYTLDI RQNSESFEAV IEEVFAAARR VPGGKRYSEL AEAEKVELLI 450
QELQTPRPLL FPGALEVEDA FSADTTKELG IFLAAAQAVR DFGSRSIAHC 500
IISMTATVSD ILEPMVLLKE VGLRDVDVVP LFETIDDLRC GAAILRELWS 550
HPFYREHLRA RGDIQEVMLG YSDSNKDGGY LQANWALYDA ELGLVELCRE 600
HNIELRLAHG RGGAVGRGGG PTYDAILAQP KGAVSGSVRI TEQGEVISAK 650
YGAPETARRH LEAFVSGALE ASLLDTEPIA DPDRAYAIMR DLAGFSGQRY 700
QELVGDPGFI EYFTQSTPLH EIGELNLGSR PAARKQTTAI SDLRAIPWVL 750
SWSQSRTNIP GWFGVGSAVS RFVSAVPEKD RESRWQELRD LYATWPFFRS 800
VMSNMAQVMA KAEISLARLY ADLVDDPEVA DRIYALIAEE FELTRRAYLA 850
ITGNDALVSE NQRQARSLKR RYPYLLPLNA IQLELLRRYR GGDDQFLVSK 900
TIQVTMNGLA TALRNAG 917
Length:917
Mass (Da):102,753
Last modified:March 21, 2012 - v1
Checksum:i09ABD406C5D8CFB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003212 Genomic DNA. Translation: AEX74284.1.
RefSeqiWP_014301801.1. NC_016786.1.
YP_005135832.1. NC_016786.1.

Genome annotation databases

EnsemblBacteriaiAEX74284; AEX74284; CDHC01_1033.
GeneIDi11709980.
KEGGicdt:CDHC01_1033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003212 Genomic DNA. Translation: AEX74284.1 .
RefSeqi WP_014301801.1. NC_016786.1.
YP_005135832.1. NC_016786.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX74284 ; AEX74284 ; CDHC01_1033 .
GeneIDi 11709980.
KEGGi cdt:CDHC01_1033.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci CDIP698967:GHQ6-1061-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HC01Imported.

Entry informationi

Entry nameiH2H6Q7_CORDH
AccessioniPrimary (citable) accession number: H2H6Q7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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