H2GQS5 (H2GQS5_CORDB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
Short name=PEPC HAMAP-Rule MF_00595
Short name=PEPCase HAMAP-Rule MF_00595
EC=4.1.1.31 HAMAP-Rule MF_00595

Gene names

Name:	ppc HAMAP-Rule MF_00595 EMBL AEX48628.1
Ordered Locus Names:	CDBH8_1105 EMBL AEX48628.1

Organism

Corynebacterium diphtheriae (strain BH8) [Complete proteome] [HAMAP] EMBL AEX48628.1

Taxonomic identifier

698973 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium diphtheriae

Protein attributes

Sequence length	917 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. SAAS SAAS021135 HAMAP-Rule MF_00595
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00595 SAAS SAAS021135
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00595
Sequence similarities	Belongs to the PEPCase type 1 family. HAMAP-Rule MF_00595

Ontologies

Keywords
Biological process	Carbon dioxide fixation SAAS SAAS021135 HAMAP-Rule MF_00595
Ligand	Magnesium SAAS SAAS021135 HAMAP-Rule MF_00595 Pyruvate EMBL AEX48628.1
Molecular function	Lyase SAAS SAAS021135 HAMAP-Rule MF_00595 EMBL AEX48628.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic process Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	147	1	By similarity HAMAP-Rule MF_00595
	Active site	576	1	By similarity HAMAP-Rule MF_00595

Sequences

	Sequence		Length	Mass (Da)
	H2GQS5 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: 09AA65B6C5D8CEB6	FASTA	917	102,767
	10 20 30 40 50 60 MGTLCIHHFC RKAELVTAAI SDRVREDIRL LGRVLGRVIA QQEGEEVYEL VEATRRMAFD 70 80 90 100 110 120 VSHGDADPED LMVIFRDLDI TKTNLVARAF SYFALLANLV EDLDDESVEA DVSLRKTFAK 130 140 150 160 170 180 LKREGVSAAD AASVIRSAEV APVLTAHPTE TRRRTVFDTQ TRIKQLLKDA HHGGDMQVIE 190 200 210 220 230 240 QEMYLRMTLL WQTALIRIAR PTLEDEIDVG LRYYKKSLLE QVPALNRSIR HSMRETFGLQ 250 260 270 280 290 300 LPDIAVMRPG SWIGGDHDGN PYVNARTLTY ATRQAAKTVA RYYVEQLGEL ERELSLSDRY 310 320 330 340 350 360 SSCSKELLAL AEASGNNWES RVDEPYRRAV YGMRARMKSN VDALERPEKT AGKKSSKRTP 370 380 390 400 410 420 YATPEEFLRD LDVIDRSLRA HNDDVIADDR LARIRSAVTT FGFHLYTLDI RQNSESFEAV 430 440 450 460 470 480 IEEVFAAARR VPGGKRYSEL AEAEKVELLI QELQTPRPLL FPGALEVEDA FSADTTKELG 490 500 510 520 530 540 IFLAAAQAVR DFGSRSIAHC IISMTATVSD ILEPMVLLKE VGLRDVDVVP LFETIDDLRC 550 560 570 580 590 600 GAAILRELWS HPFYREHLRA RGDIQEVMLG YSDSNKDGGY LQANWALYDA ELGLVELCRE 610 620 630 640 650 660 HNIELRLAHG RGGAVGRGGG PTYDAILAQP KGAVSGSVRI TEQGEVISAK YGAPETARRH 670 680 690 700 710 720 LEAFVSGALE ASLLDTEPIA DPDRAYAIMR DLAGFSGQRY QELVGDPGFI EYFTQSTPLH 730 740 750 760 770 780 EIGELNLGSR PAARKQTTAI SDLRAIPWVL SWSQSRTNIP GWFGVGSAVS RFVSAVPEKD 790 800 810 820 830 840 RESRWQELRD LYATWPFFRS VMSNMAQVMA KAEISLARLY ADLVDDPEVA DRIYALIAEE 850 860 870 880 890 900 FELTRRAYLA ITGNEALVSE NQRQARSLKR RYPYLLPLNA IQLELLRRYR GGDDQFLVSK 910 TIQVTMNGLA TALRNAG

References

[1]

"Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia." Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr. , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A. J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BH8 EMBL AEX48628.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003209 Genomic DNA. Translation: AEX48628.1.
RefSeq	YP_005160195.1. NC_016800.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEX48628; AEX48628; CDBH8_1105.
GeneID	11734091.
KEGG	cdb:CDBH8_1105.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K01595.
Enzyme and pathway databases
BioCyc	CDIP698973:GHAI-1132-MONOMER.
Family and domain databases
HAMAP	MF_00595. PEPcase_type1.
InterPro	IPR021135. PEP_COase. IPR018129. PEP_COase_AS. IPR022805. PEP_COase_bac/pln-type. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. [Graphical view]
Pfam	PF00311. PEPcase. 1 hit. [Graphical view]
PRINTS	PR00150. PEPCARBXLASE.
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITE	PS00781. PEPCASE_1. 1 hit. PS00393. PEPCASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H2GQS5_CORDB

Accession

Primary (citable) accession number: H2GQS5

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	May 29, 2013
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)