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H2GMK0

- H2GMK0_CORDB

UniProt

H2GMK0 - H2GMK0_CORDB

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Protein

Alanine racemase

Gene
alr, CDBH8_0522
Organism
Corynebacterium diphtheriae (strain BH8)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei261 – 2611Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei309 – 3091Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCDIP698973:GHAI-539-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CDBH8_0522Imported
OrganismiCorynebacterium diphtheriae (strain BH8)Imported
Taxonomic identifieri698973 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007866: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH2GMK0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

H2GMK0-1 [UniParc]FASTAAdd to Basket

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MNLLETRISC EAIAANTRRL KDMVAPAQLM CVVKADGYNH GAPEVATVMA    50
RNGADQFGVA TLAEAHQLRD AGITLPILCW IWSPEQDFSA AIDRDIDLAA 100
VSMEHVRALI AEAMRRPAGT RVRVTVKIDT ELHRSGIDEA NWTEAFELLH 150
ACPQINVTGV FSHLACADDL ESDYTDHQAE VFRRAISAGR NVGLDLPVNH 200
LAASPATLTR PDLHFDMVRP GLALYGHEPI AGLDHGLREA MTWIGSVTVV 250
KPIAAGQGTS YNMTWHAPAD GYLCVVPVGY ADGLPRNVQG HLEVTIAGTR 300
YPQVGRVCMD QIVVFLGDNS RGVAPGDEAI IFGPRDTQAM TVTELACATG 350
TINYEILCRP TGRSHRTYSD FDAVAPTHPT ES 382
Length:382
Mass (Da):41,355
Last modified:March 21, 2012 - v1
Checksum:i93EFA1197D046990
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003209 Genomic DNA. Translation: AEX48047.1.
RefSeqiWP_014317607.1. NC_016800.1.
YP_005159614.1. NC_016800.1.

Genome annotation databases

EnsemblBacteriaiAEX48047; AEX48047; CDBH8_0522.
GeneIDi11733152.
KEGGicdb:CDBH8_0522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003209 Genomic DNA. Translation: AEX48047.1 .
RefSeqi WP_014317607.1. NC_016800.1.
YP_005159614.1. NC_016800.1.

3D structure databases

ProteinModelPortali H2GMK0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX48047 ; AEX48047 ; CDBH8_0522 .
GeneIDi 11733152.
KEGGi cdb:CDBH8_0522.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CDIP698973:GHAI-539-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BH8Imported.

Entry informationi

Entry nameiH2GMK0_CORDB
AccessioniPrimary (citable) accession number: H2GMK0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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