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H2GJG0

- H2GJG0_CORDN

UniProt

H2GJG0 - H2GJG0_CORDN

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Protein
Elongation factor Tu
Gene
tuf, CDB402_0383
Organism
Corynebacterium diphtheriae (strain INCA 402)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarityUniRule annotation
Nucleotide bindingi83 – 875GTP By similarityUniRule annotation
Nucleotide bindingi138 – 1414GTP By similarityUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported, HydrolaseImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCDIP698972:GI1X-400-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotationImported
    Ordered Locus Names:CDB402_0383Imported
    OrganismiCorynebacterium diphtheriae (strain INCA 402)Imported
    Taxonomic identifieri698972 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000007867: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer By similarity.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH2GJG0.
    SMRiH2GJG0. Positions 2-395.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK02358.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2GJG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKAKFERTK PHVNIGTIGH VDHGKTTTTA AITKVLADAY PELNEAFAFD    50
    AIDKAPEEKE RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ 100
    MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKC DMVDDEEIIE 150
    LVEMEIRELL AEQDYDEEAP IIHISALKAL EGDEKWTQSI IDLMQACDDS 200
    IPDPERETDK PFLMPIEDIF TITGRGTVVT GRVERGSLKV NEDVEIIGIR 250
    EKATTTTVTG IEMFRKLLDY TEAGDNCGLL LRGVKREDVE RGQVVVKPGA 300
    YTPHTEFEGS VYVLSKDEGG RHTPFFDNYR PQFYFRTTDV TGVVKLPEGT 350
    EMVMPGDNVD MSVTLIQPVA MDEGLRFAIR EGSRTVGAGR VTKIIK 396
    Length:396
    Mass (Da):43,944
    Last modified:March 21, 2012 - v1
    Checksum:iAFDEAE4CF3C9FC27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003208 Genomic DNA. Translation: AEX45694.1.
    RefSeqiYP_005126896.1. NC_016783.1.

    Genome annotation databases

    EnsemblBacteriaiAEX45694; AEX45694; CDB402_0383.
    GeneIDi11671617.
    KEGGicdh:CDB402_0383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003208 Genomic DNA. Translation: AEX45694.1 .
    RefSeqi YP_005126896.1. NC_016783.1.

    3D structure databases

    ProteinModelPortali H2GJG0.
    SMRi H2GJG0. Positions 2-395.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEX45694 ; AEX45694 ; CDB402_0383 .
    GeneIDi 11671617.
    KEGGi cdh:CDB402_0383.

    Phylogenomic databases

    KOi K02358.

    Enzyme and pathway databases

    BioCyci CDIP698972:GI1X-400-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
      Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
      , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
      J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: INCA 402Imported.

    Entry informationi

    Entry nameiH2GJG0_CORDN
    AccessioniPrimary (citable) accession number: H2GJG0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: June 11, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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