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H2GEP4 (H2GEP4_CORD2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138 EMBL AEX44900.1
Ordered Locus Names:CD241_1845 EMBL AEX44900.1
OrganismCorynebacterium diphtheriae (strain 241) [Complete proteome] [HAMAP] EMBL AEX44900.1
Taxonomic identifier698966 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 312204ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding138 – 19356ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2821Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2841Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
H2GEP4 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: EA8CC4C09995C584

FASTA42844,736
        10         20         30         40         50         60 
MRILVIGSGA REHALVLGLS KDPSVSEIHV APGNAGMEQI ATVHADATSV DDPAQMLQVA 

        70         80         90        100        110        120 
QDVQADLVVV GPEIPLVAGV ADVLRQNGFA VFGPNKDAAR IEGSKAFAKD VMEKAGVRTA 

       130        140        150        160        170        180 
RAEQILPEAS DEQRDAALDR FGPHYVVKDD GLAGGKGVVV TDDREVARAH VDAVLAAGNP 

       190        200        210        220        230        240 
VLLESFLDGP EVSLFCLVDG ETVVPLIPAQ DHKRAYDNDE GPNTGGMGAY TPLPWLPEDG 

       250        260        270        280        290        300 
VQRIVDEVCV PVAREMVRRG CSYSGLLYAG LAWGAEGPSV VEFNCRFGDP ETQAVLALLR 

       310        320        330        340        350        360 
TPLAQVLQSV AEGTLAQAPA LEWQDGYALT VVLAAEGYPE IPRKGGVITG ADVADASGTT 

       370        380        390        400        410        420 
AVLHAGTARD EQGNVVANGG RVLNVVGTGA TLADARDNAY RVLEGIKLEG SHFRSDIALP 


AVEGRISI

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References

[1]"Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia."
Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr. expand/collapse author list , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 241.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003207 Genomic DNA. Translation: AEX44900.1.
RefSeqYP_005126102.1. NC_016782.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEX44900; AEX44900; CD241_1845.
GeneID11672645.
KEGGcdp:CD241_1845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01945.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH2GEP4_CORD2
AccessionPrimary (citable) accession number: H2GEP4
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: May 1, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info