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H2GAP6

- H2GAP6_CORD2

UniProt

H2GAP6 - H2GAP6_CORD2

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Corynebacterium diphtheriae (strain 241)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471UniRule annotation
    Active sitei576 – 5761UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    Ordered Locus Names:CD241_1033Imported
    OrganismiCorynebacterium diphtheriae (strain 241)Imported
    Taxonomic identifieri698966 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000007868: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    KOiK01595.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H2GAP6-1 [UniParc]FASTAAdd to Basket

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    MGTLCIHHFC RKAELVTAAI SDRVREDIRL LGRVLGRVIA QQEGEEVYEL    50
    VEATRRMAFD VSHGDADPED LMVIFRDLDI TKTNLVARAF SYFALLANLV 100
    EDLDDESVEA DVSLRKTFAK LKREGVSAAD AASVIRSAEV APVLTAHPTE 150
    TRRRTVFDTQ TRIKQLLKDA HHGGDMQVIE QEMYLRMTLL WQTALIRIAR 200
    PTLEDEIDVG LRYYKKSLLE QVPALNRSIR HSMRETFGLQ LPDIAVMRPG 250
    SWIGGDHDGN PYVNARTLTY ATRQAAKTVA RYYVEQLGEL ERELSLSDRY 300
    SSCSKELLAL AEASGNNWES RVDEPYRRAV YGMRARMKSN VDALERPEKT 350
    AGKKSSKRTP YATPEEFLRD LDVIDRSLRA HNDDVIADDR LARIRSAVTT 400
    FGFHLYTLDI RQNSESFEAV IEEVFAAARR VPGGKRYSEL AEAEKVELLI 450
    QELQTPRPLL FPGALEVEDA FSADTTKELG IFLAAAQAVR DFGSRSIAHC 500
    IISMTATVSD ILEPMVLLKE VGLRDVDVVP LFETIDDLRC GAAILRELWS 550
    HPFYREHLRA RGDIQEVMLG YSDSNKDGGY LQANWALYDA ELGLVELCRE 600
    HNIELRLAHG RGGAVGRGGG PTYDAILAQP KGAVSGSVRI TEQGEVISAK 650
    YGAPETARRH LEAFVSGALE ASLLDTEPIA DPDRAYAIMR DLAGFSGQRY 700
    QELVGDPGFI EYFTQSTPLH EIGELNLGSR PAARKQTTAI SDLRAIPWVL 750
    SWSQSRTNIP GWFGVGSAVS RFVSAVPEKD RESRWQELRD LYATWPFFRS 800
    VMSNMAQVMA KAEISLARLY ADLVDDPEVA DRIYALIAEE FELTRRAYLA 850
    ITGNDALVSE NQRQARSLKR RYPYLLPLNA IQLELLRRYR GGDDQFLVSK 900
    TIQVTMNGLA TALRNAG 917
    Length:917
    Mass (Da):102,753
    Last modified:March 21, 2012 - v1
    Checksum:i09ABD406C5D8CFB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003207 Genomic DNA. Translation: AEX44098.1.
    RefSeqiYP_005125300.1. NC_016782.1.

    Genome annotation databases

    EnsemblBacteriaiAEX44098; AEX44098; CD241_1033.
    GeneIDi11673940.
    KEGGicdp:CD241_1033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003207 Genomic DNA. Translation: AEX44098.1 .
    RefSeqi YP_005125300.1. NC_016782.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEX44098 ; AEX44098 ; CD241_1033 .
    GeneIDi 11673940.
    KEGGi cdp:CD241_1033.

    Phylogenomic databases

    KOi K01595.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia."
      Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr.
      , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
      J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 241Imported.

    Entry informationi

    Entry nameiH2GAP6_CORD2
    AccessioniPrimary (citable) accession number: H2GAP6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3