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H2G8D9 (H2G8D9_CORD3) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ispE HAMAP-Rule MF_00061 EMBL AEX41565.1
Ordered Locus Names:CD31A_0886 EMBL AEX41565.1
OrganismCorynebacterium diphtheriae (strain 31A) [Complete proteome] [HAMAP] EMBL AEX41565.1
Taxonomic identifier698962 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding114 – 12411ATP By similarity HAMAP-Rule MF_00061

Sites

Active site131 By similarity HAMAP-Rule MF_00061
Active site1561 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
H2G8D9 [UniParc].

Last modified March 21, 2012. Version 1.
Checksum: 301EE576E1B6FC3F

FASTA31132,340
        10         20         30         40         50         60 
MTSYAITAVA SSKVNLHLGI GNARDDGYHE LVTVFQSLSL HDTITVTPAA DDMHDAEDQG 

        70         80         90        100        110        120 
IVATLSVSGD SAQAVPTDAT NLAWQAAEKM YKAHRRNGGA PAKRVHIAID KGIPVAGGMA 

       130        140        150        160        170        180 
GGSADAAATL AAMAQYLGNT NTEQEILSIA AELGSDVPFT YLGDTRLGTG RGEQLVPVLS 

       190        200        210        220        230        240 
RGTYHWALAF SAQGLSTPEV FRKIDQMDRQ PHLDVTALNA ALITGDPHKV AAHLHNDLQA 

       250        260        270        280        290        300 
AALSLRPELR TTLEQGRAAG ALAGIVSGSG PTCAFLCEDA ETAQAVAAEL SVHYRTAVAT 

       310 
GPVRGAHVKG H

« Hide

References

[1]"Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia."
Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr. expand/collapse author list , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 31A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003206 Genomic DNA. Translation: AEX41565.1.
RefSeqYP_005157592.1. NC_016799.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEX41565; AEX41565; CD31A_0886.
GeneID11732424.
KEGGcdz:CD31A_0886.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00919.

Enzyme and pathway databases

UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH2G8D9_CORD3
AccessionPrimary (citable) accession number: H2G8D9
Entry history
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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