H2G6Z5 (H2G6Z5_CORD3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL AEX41312.1
EC=1.1.1.42 EMBL AEX41312.1

Gene names

Name:	icd EMBL AEX41312.1
Ordered Locus Names:	CD31A_0633 EMBL AEX41312.1

Organism

Corynebacterium diphtheriae (strain 31A) [Complete proteome] [HAMAP] EMBL AEX41312.1

Taxonomic identifier

698962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium diphtheriae

Protein attributes

Sequence length	737 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL AEX41312.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	130 – 137	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	346	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	544	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	548	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	143	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	543	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	253	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	416	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	H2G6Z5 [UniParc]. Last modified March 21, 2012. Version 1. Checksum: DDDA658ACA98A1F5	FASTA	737	79,597
	10 20 30 40 50 60 MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILAQF PDYLNEDQKV 70 80 90 100 110 120 DDALAELGEL AKTPEANIIK LPNISASLPQ LKAAIAELKA QGFALPEYPD SPATDEEKDV 130 140 150 160 170 180 RARYDAVKGS AVNPVLREGN SDRRAPIAVK NFAKKNPHKM GVWSSDSKTN VATMDANDFR 190 200 210 220 230 240 HNEKSVIMPA ADTLTIKHIA TDGTETILKD GLKVLEGEVI DGTFLSAKAL DAFLTEQVQR 250 260 270 280 290 300 AKDENVLFSA HLKATMMKVS DPIIFGHVVR AYFADVFATY DDQLNAAGLN GENGLAAIYS 310 320 330 340 350 360 GLDALDNGAE IKAAFDAALE AGADVAMVNS AKGITNLHVP SDVIIDASMP AMIRTAGHMW 370 380 390 400 410 420 NKDDQEQDTL AVIPDSSYAS VYQVVIEDCK KNGAFDPTTM GTVPNVGLMA QKAEEYGSHD 430 440 450 460 470 480 KTFKIAADGK VIVVNAAGEA LIEHDVEAGD IWRACQAKDA PIQDWVKLAV TRSRLSGMPA 490 500 510 520 530 540 VFWLDPERAH DRNLITLVKK YLANHDTEGL NIQIMSPTEA TQFSIDRIRR GEDTISVTGN 550 560 570 580 590 600 VLRDYNTDLF PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENHLRWDSL 610 620 630 640 650 660 GEFLALAESL RHFANTEGNT KAGILADALD RATETLLNEG YSPSRKAGEI DNRGSHFFLT 670 680 690 700 710 720 LNWAKELAAQ TDDTTLAETF APVAAQLEEN KDTIAAALID VQGTPVDLGG YYQPDDAKTA 730 AVMRPVAEFN DIIDALN

References

[1]

"Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia." Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr. , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A. J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 31A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003206 Genomic DNA. Translation: AEX41312.1.
RefSeq	YP_005157339.1. NC_016799.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEX41312; AEX41312; CD31A_0633.
GeneID	11731776.
KEGG	cdz:CD31A_0633.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

H2G6Z5_CORD3

Accession

Primary (citable) accession number: H2G6Z5

Entry history

Integrated into UniProtKB/TrEMBL:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)