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H2G6Z5

- H2G6Z5_CORD3

UniProt

H2G6Z5 - H2G6Z5_CORD3

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Corynebacterium diphtheriae (strain 31A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei253 – 2531Critical for catalysisUniRule annotation
Metal bindingi346 – 3461Magnesium or manganeseUniRule annotation
Sitei416 – 4161Critical for catalysisUniRule annotation
Binding sitei543 – 5431SubstrateUniRule annotation
Metal bindingi544 – 5441Magnesium or manganeseUniRule annotation
Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCDIP698962:GH9X-649-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:CD31A_0633Imported
OrganismiCorynebacterium diphtheriae (strain 31A)Imported
Taxonomic identifieri698962 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007869: Chromosome

Family & Domainsi

Phylogenomic databases

KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H2G6Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILAQF
60 70 80 90 100
PDYLNEDQKV DDALAELGEL AKTPEANIIK LPNISASLPQ LKAAIAELKA
110 120 130 140 150
QGFALPEYPD SPATDEEKDV RARYDAVKGS AVNPVLREGN SDRRAPIAVK
160 170 180 190 200
NFAKKNPHKM GVWSSDSKTN VATMDANDFR HNEKSVIMPA ADTLTIKHIA
210 220 230 240 250
TDGTETILKD GLKVLEGEVI DGTFLSAKAL DAFLTEQVQR AKDENVLFSA
260 270 280 290 300
HLKATMMKVS DPIIFGHVVR AYFADVFATY DDQLNAAGLN GENGLAAIYS
310 320 330 340 350
GLDALDNGAE IKAAFDAALE AGADVAMVNS AKGITNLHVP SDVIIDASMP
360 370 380 390 400
AMIRTAGHMW NKDDQEQDTL AVIPDSSYAS VYQVVIEDCK KNGAFDPTTM
410 420 430 440 450
GTVPNVGLMA QKAEEYGSHD KTFKIAADGK VIVVNAAGEA LIEHDVEAGD
460 470 480 490 500
IWRACQAKDA PIQDWVKLAV TRSRLSGMPA VFWLDPERAH DRNLITLVKK
510 520 530 540 550
YLANHDTEGL NIQIMSPTEA TQFSIDRIRR GEDTISVTGN VLRDYNTDLF
560 570 580 590 600
PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENHLRWDSL
610 620 630 640 650
GEFLALAESL RHFANTEGNT KAGILADALD RATETLLNEG YSPSRKAGEI
660 670 680 690 700
DNRGSHFFLT LNWAKELAAQ TDDTTLAETF APVAAQLEEN KDTIAAALID
710 720 730
VQGTPVDLGG YYQPDDAKTA AVMRPVAEFN DIIDALN
Length:737
Mass (Da):79,597
Last modified:March 21, 2012 - v1
Checksum:iDDDA658ACA98A1F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003206 Genomic DNA. Translation: AEX41312.1.
RefSeqiYP_005157339.1. NC_016799.1.

Genome annotation databases

EnsemblBacteriaiAEX41312; AEX41312; CD31A_0633.
GeneIDi11731776.
KEGGicdz:CD31A_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003206 Genomic DNA. Translation: AEX41312.1 .
RefSeqi YP_005157339.1. NC_016799.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX41312 ; AEX41312 ; CD31A_0633 .
GeneIDi 11731776.
KEGGi cdz:CD31A_0633.

Phylogenomic databases

KOi K00031.
OMAi EEQRIGD.

Enzyme and pathway databases

BioCyci CDIP698962:GH9X-649-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 31AImported.

Entry informationi

Entry nameiH2G6Z5_CORD3
AccessioniPrimary (citable) accession number: H2G6Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3