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H2G6Z5

- H2G6Z5_CORD3

UniProt

H2G6Z5 - H2G6Z5_CORD3

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

icd

Organism
Corynebacterium diphtheriae (strain 31A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431Substrate
    Sitei253 – 2531Critical for catalysisUniRule annotation
    Metal bindingi346 – 3461Magnesium or manganeseUniRule annotation
    Sitei416 – 4161Critical for catalysisUniRule annotation
    Binding sitei543 – 5431SubstrateUniRule annotation
    Metal bindingi544 – 5441Magnesium or manganeseUniRule annotation
    Metal bindingi548 – 5481Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciCDIP698962:GH9X-649-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:CD31A_0633Imported
    OrganismiCorynebacterium diphtheriae (strain 31A)Imported
    Taxonomic identifieri698962 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000007869: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1378Substrate binding

    Phylogenomic databases

    KOiK00031.
    OMAiEEQRIGD.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H2G6Z5-1 [UniParc]FASTAAdd to Basket

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    MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILAQF    50
    PDYLNEDQKV DDALAELGEL AKTPEANIIK LPNISASLPQ LKAAIAELKA 100
    QGFALPEYPD SPATDEEKDV RARYDAVKGS AVNPVLREGN SDRRAPIAVK 150
    NFAKKNPHKM GVWSSDSKTN VATMDANDFR HNEKSVIMPA ADTLTIKHIA 200
    TDGTETILKD GLKVLEGEVI DGTFLSAKAL DAFLTEQVQR AKDENVLFSA 250
    HLKATMMKVS DPIIFGHVVR AYFADVFATY DDQLNAAGLN GENGLAAIYS 300
    GLDALDNGAE IKAAFDAALE AGADVAMVNS AKGITNLHVP SDVIIDASMP 350
    AMIRTAGHMW NKDDQEQDTL AVIPDSSYAS VYQVVIEDCK KNGAFDPTTM 400
    GTVPNVGLMA QKAEEYGSHD KTFKIAADGK VIVVNAAGEA LIEHDVEAGD 450
    IWRACQAKDA PIQDWVKLAV TRSRLSGMPA VFWLDPERAH DRNLITLVKK 500
    YLANHDTEGL NIQIMSPTEA TQFSIDRIRR GEDTISVTGN VLRDYNTDLF 550
    PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENHLRWDSL 600
    GEFLALAESL RHFANTEGNT KAGILADALD RATETLLNEG YSPSRKAGEI 650
    DNRGSHFFLT LNWAKELAAQ TDDTTLAETF APVAAQLEEN KDTIAAALID 700
    VQGTPVDLGG YYQPDDAKTA AVMRPVAEFN DIIDALN 737
    Length:737
    Mass (Da):79,597
    Last modified:March 21, 2012 - v1
    Checksum:iDDDA658ACA98A1F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003206 Genomic DNA. Translation: AEX41312.1.
    RefSeqiWP_014316433.1. NC_016799.1.
    YP_005157339.1. NC_016799.1.

    Genome annotation databases

    EnsemblBacteriaiAEX41312; AEX41312; CD31A_0633.
    GeneIDi11731776.
    KEGGicdz:CD31A_0633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003206 Genomic DNA. Translation: AEX41312.1 .
    RefSeqi WP_014316433.1. NC_016799.1.
    YP_005157339.1. NC_016799.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEX41312 ; AEX41312 ; CD31A_0633 .
    GeneIDi 11731776.
    KEGGi cdz:CD31A_0633.

    Phylogenomic databases

    KOi K00031.
    OMAi EEQRIGD.

    Enzyme and pathway databases

    BioCyci CDIP698962:GH9X-649-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia."
      Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R. Jr.
      , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
      J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 31AImported.

    Entry informationi

    Entry nameiH2G6Z5_CORD3
    AccessioniPrimary (citable) accession number: H2G6Z5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3