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H2G6Z5

- H2G6Z5_CORD3

UniProt

H2G6Z5 - H2G6Z5_CORD3

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Protein
Submitted name: Isocitrate dehydrogenase
Gene
icd, CD31A_0633
Organism
Corynebacterium diphtheriae (strain 31A)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei253 – 2531Critical for catalysis By similarityUniRule annotation
Metal bindingi346 – 3461Magnesium or manganese By similarityUniRule annotation
Sitei416 – 4161Critical for catalysis By similarityUniRule annotation
Binding sitei543 – 5431Substrate By similarityUniRule annotation
Metal bindingi544 – 5441Magnesium or manganese By similarityUniRule annotation
Metal bindingi548 – 5481Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCDIP698962:GH9X-649-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:CD31A_0633Imported
OrganismiCorynebacterium diphtheriae (strain 31A)Imported
Taxonomic identifieri698962 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000007869: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate binding By similarityUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

H2G6Z5-1 [UniParc]FASTAAdd to Basket

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MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILAQF    50
PDYLNEDQKV DDALAELGEL AKTPEANIIK LPNISASLPQ LKAAIAELKA 100
QGFALPEYPD SPATDEEKDV RARYDAVKGS AVNPVLREGN SDRRAPIAVK 150
NFAKKNPHKM GVWSSDSKTN VATMDANDFR HNEKSVIMPA ADTLTIKHIA 200
TDGTETILKD GLKVLEGEVI DGTFLSAKAL DAFLTEQVQR AKDENVLFSA 250
HLKATMMKVS DPIIFGHVVR AYFADVFATY DDQLNAAGLN GENGLAAIYS 300
GLDALDNGAE IKAAFDAALE AGADVAMVNS AKGITNLHVP SDVIIDASMP 350
AMIRTAGHMW NKDDQEQDTL AVIPDSSYAS VYQVVIEDCK KNGAFDPTTM 400
GTVPNVGLMA QKAEEYGSHD KTFKIAADGK VIVVNAAGEA LIEHDVEAGD 450
IWRACQAKDA PIQDWVKLAV TRSRLSGMPA VFWLDPERAH DRNLITLVKK 500
YLANHDTEGL NIQIMSPTEA TQFSIDRIRR GEDTISVTGN VLRDYNTDLF 550
PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENHLRWDSL 600
GEFLALAESL RHFANTEGNT KAGILADALD RATETLLNEG YSPSRKAGEI 650
DNRGSHFFLT LNWAKELAAQ TDDTTLAETF APVAAQLEEN KDTIAAALID 700
VQGTPVDLGG YYQPDDAKTA AVMRPVAEFN DIIDALN 737
Length:737
Mass (Da):79,597
Last modified:March 21, 2012 - v1
Checksum:iDDDA658ACA98A1F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003206 Genomic DNA. Translation: AEX41312.1.
RefSeqiWP_014316433.1. NC_016799.1.
YP_005157339.1. NC_016799.1.

Genome annotation databases

EnsemblBacteriaiAEX41312; AEX41312; CD31A_0633.
GeneIDi11731776.
KEGGicdz:CD31A_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003206 Genomic DNA. Translation: AEX41312.1 .
RefSeqi WP_014316433.1. NC_016799.1.
YP_005157339.1. NC_016799.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEX41312 ; AEX41312 ; CD31A_0633 .
GeneIDi 11731776.
KEGGi cdz:CD31A_0633.

Phylogenomic databases

KOi K00031.
OMAi EEQRIGD.

Enzyme and pathway databases

BioCyci CDIP698962:GH9X-649-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia."
    Trost E., Blom J., de Castro Soares S., Huang I.H., Al-Dilaimi A., Schroder J., Jaenicke S., Dorella F.A., Rocha F.S., Miyoshi A., Azevedo V., Schneider M.P., Silva A., Camello T.C., Sabbadini P.S., Santos C.S., Santos L.S., Hirata R.Jr.
    , Mattos-Guaraldi A.L., Efstratiou A., Schmitt M.P., Ton-That H., Tauch A.
    J. Bacteriol. 194:3199-3215(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 31AImported.

Entry informationi

Entry nameiH2G6Z5_CORD3
AccessioniPrimary (citable) accession number: H2G6Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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